Ping-pong cell-fate control

2004 ◽  
Vol 2 (10) ◽  
pp. 771-771
Author(s):  
Susan Jones
Keyword(s):  
Cell Fate ◽  
Fate Control ◽  
Ping Pong ◽  
Cell Fate Control

scholarly journals Non-cell-autonomous promotion of pluripotency induction mediated by YAP

2018 ◽  
Author(s):  
Amaleah Hartman ◽  
Xiao Hu ◽  
Xinyue Chen ◽  
Anna E. Eastman ◽  
Cindy Yang ◽  
...  
Keyword(s):  
Cell Fate ◽  
Pluripotent Stem Cells ◽  
Cell Types ◽  
Matricellular Proteins ◽  
Fate Control ◽  
Promotional Effect ◽  
Cellular Context ◽  
Opposing Effects ◽  
Cell Fate Control ◽  
Heterologous Cell

SUMMARYWhile Yes-associated protein (YAP) antagonizes pluripotency during early embryogenesis, it has also been shown to promote stemness of multiple stem cell types, including pluripotent stem cells. Whether cellular context underlies these distinct functions of YAP in pluripotency remains unclear. Here, we establish that depending on the specific cells in which it is expressed, YAP exhibits opposing effects on pluripotency induction from somatic cells. Specifically, YAP inhibits pluripotency induction cell-autonomously but promotes it non-cell-autonomously. For its non-cell-autonomous role, YAP alters the expression of many secreted and matricellular proteins including CYR61, which recapitulates the promotional effect when added as a recombinant protein. Thus, we define a unique YAP-driven non-cell-autonomous process that enhances pluripotency induction. Our work highlights the importance of considering the distinct contributions from heterologous cell types in deciphering the mechanism of cell fate control and calls for careful re-examination of the co-existing bystander cells in complex cultures or tissues.

Neural Stem Cell Fate Control on Micropatterned Substrates

2017 ◽  
pp. 19-44 ◽  
Author(s):  
Leonora Buzanska ◽  
Marzena Zychowicz ◽  
Ana Ruiz ◽  
François Rossi
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Stem Cell Fate ◽  
Fate Control ◽  
Cell Fate Control

scholarly journals The histone demethylase UTX enables RB-dependent cell fate control

2010 ◽  
Vol 24 (4) ◽  
pp. 327-332 ◽  
Author(s):  
J. K. Wang ◽  
M.-C. Tsai ◽  
G. Poulin ◽  
A. S. Adler ◽  
S. Chen ◽  
...  
Keyword(s):  
Cell Fate ◽  
Histone Demethylase ◽  
Fate Control ◽  
Dependent Cell ◽  
Cell Fate Control

scholarly journals DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control

BMC Biology ◽  
2013 ◽  
Vol 11 (1) ◽  
pp. 73 ◽  
Author(s):  
Xi Chen ◽  
Jia Chen ◽  
Siting Gan ◽  
Huaji Guan ◽  
Yuan Zhou ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Fate ◽  
Fate Control ◽  
Cell Fate Control

scholarly journals ANALYSIS OF INTRACELLULAR SIGNALING KINETICS PREDICTS PRESENTATION MODES AND TARGETS FOR STEM CELL FATE CONTROL

2005 ◽  
Vol preprint (2007) ◽  
pp. e130
Author(s):  
Alborz Mahdavi ◽  
Ryan E Davey ◽  
Patrick Bhola ◽  
Ting Yin ◽  
Peter W Zandstra
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Intracellular Signaling ◽  
Stem Cell Fate ◽  
Fate Control ◽  
Presentation Modes ◽  
Cell Fate Control

scholarly journals Towards 4th generation biomaterials: a covalent hybrid polymer–ormoglass architecture

Nanoscale ◽  
2015 ◽  
Vol 7 (37) ◽  
pp. 15349-15361 ◽  
Author(s):  
N. Sachot ◽  
M. A. Mateos-Timoneda ◽  
J. A. Planell ◽  
A. H. Velders ◽  
M. Lewandowska ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Cell Fate ◽  
Hybrid Materials ◽  
Hybrid Polymer ◽  
Fate Control ◽  
Cell Fate Control

Nanostructured hybrid materials are an excellent option to create extracellular matrix-like environments for cell fate control in bone tissue engineering.

scholarly journals Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

Nano Today ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. 759-784 ◽  
Author(s):  
Weiqiang Chen ◽  
Yue Shao ◽  
Xiang Li ◽  
Gang Zhao ◽  
Jianping Fu
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Control Engineering ◽  
Stem Cell Fate ◽  
Fate Control ◽  
Cell Fate Control
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