A brief history of (DNA sequencing) time

2007 ◽  
Vol 8 (S1) ◽  
pp. S21-S21
Author(s):  
Elaine R. Mardis
Keyword(s):  
Dna Sequencing ◽  
History Of

scholarly journals Whole mitochondrial DNA sequencing in Alpine populations and the genetic history of the Neolithic Tyrolean Iceman

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
V. Coia ◽  
G. Cipollini ◽  
P. Anagnostou ◽  
F. Maixner ◽  
C. Battaggia ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Sequencing ◽  
Genetic History ◽  
History Of ◽  
Tyrolean Iceman

scholarly journals Phylogenetic studies of eucalypts: fossils, morphology and genomes

2016 ◽  
Vol 128 (1) ◽  
pp. 12 ◽  
Author(s):  
Michael J. Bayly
Keyword(s):  
Dna Sequencing ◽  
Phylogenetic Analyses ◽  
Molecular Data ◽  
Phylogenetic Studies ◽  
Recent Advances ◽  
History Of ◽  
Morphological And Molecular Data ◽  
Economic Use ◽  
Insight Into

The eucalypt group includes seven genera: Eucalyptus, Corymbia, Angophora, Eucalyptopsis, Stockwellia, Allosyncarpia and Arillastrum. Knowledge of eucalypt phylogeny underpins classification of the group, and facilitates understanding of their ecology, conservation and economic use, as well as providing insight into the history of Australia’s flora. Studies of fossils and phylogenetic analyses of morphological and molecular data have made substantial contributions to understanding of eucalypt relationships and biogeography, but relationships among some genera are still uncertain, and there is controversy about generic circumscription of the bloodwood eucalypts (genus Corymbia). Relationships at lower taxonomic levels, e.g. among sections and series of Eucalyptus, are also not well resolved. Recent advances in DNA sequencing methods offer the ability to obtain large genomic datasets that will enable improved understanding of eucalypt evolution.

scholarly journals The History of DNA Sequencing / ISTORIJAT SEKVENCIRANJA DNK

2013 ◽  
Vol 32 (4) ◽  
pp. 301-312 ◽  
Author(s):  
Miodrag Gužvić
Keyword(s):  
Dna Sequencing ◽  
Human Genome ◽  
Genome Project ◽  
Fourth Generation ◽  
Sequencing Technologies ◽  
Current Trends ◽  
Biological Phenomena ◽  
History Of ◽  
Proportional Increase ◽  
The Cost

Summary During the last decade, the cost of DNA sequencing technologies has decreased several orders of magnitude, with the proportional increase of speed and throughput. Human Genome Project took almost 15 years to complete the sequence of the human genome. With the second and third generation technologies, this can be done in the matter of days or hours. This progress and availability of sequencing instruments to virtually every researcher leads to replacing of many techniques with DNA sequencing and opens new venues of research. DNA sequencing is used to investigate basic biological phenomena, and is probably going to be increasingly used in the context of health care (preimplantation diagnostics, oncology, infectious diseases). Current trends are aiming towards the price of 1000$ for sequencing of one human genome. Without any doubt, we can expect improvement of existing and the development of fourth generation technologies in the coming years.

A history of DNA sequence assembly

2016 ◽  
Vol 58 (3) ◽  
Author(s):  
Eugene W. Myers Jr
Keyword(s):  
Dna Sequencing ◽  
Dna Sequence ◽  
Combinatorial Problem ◽  
Sequence Assembly ◽  
Short History ◽  
Dna Sequence Assembly ◽  
History Of

AbstractDNA sequence assembly is a rich combinatorial problem that arose with the first DNA sequencing projects in the early 80's. Here we give a short history of the progression of algorithmic ideas used to solve the

Intricate evolutionary history of Callitriche (Plantaginaceae) taxa elucidated by a combination of DNA sequencing and genome size

Taxon ◽  
2020 ◽  
Vol 69 (5) ◽  
pp. 1016-1041
Author(s):  
Jan Prančl ◽  
Judith Fehrer ◽  
Petra Caklová ◽  
Veronika Bambasová ◽  
Magdalena Lučanová ◽  
...  
Keyword(s):  
Dna Sequencing ◽  
Genome Size ◽  
Evolutionary History ◽  
History Of

scholarly journals Blastomyces dermatitidis pneumonia in a llama

2018 ◽  
Vol 30 (4) ◽  
pp. 576-579
Author(s):  
Jennie M. Jankovsky ◽  
Robert L. Donnell
Keyword(s):  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Dna Sequencing ◽  
Pulmonary Disease ◽  
Carotid Arteries ◽  
Blastomyces Dermatitidis ◽  
Viscous Material ◽  
History Of ◽  
Lama Glama ◽  
Tracheobronchial Lymph Nodes

A 20-y-old female llama ( Lama glama) was euthanized after a history of chronic dyspnea and osteoarthritis. At autopsy, the lungs were covered by clear gelatinous material and expanded by firm, variably discrete, tan-white nodules up to 8 cm diameter containing tan-white, viscous material. The tracheobronchial lymph nodes were firm and enlarged up to 6 × 4 × 3 cm; the thoracic aorta and carotid arteries were lined by hard, tan-white, mineralized intimal plaques. Histologic examination of lung revealed numerous 10–20 μm diameter yeasts with clear 1–2 μm thick double-contoured walls, central basophilic nuclei, and frequent broad-based budding, consistent with Blastomyces dermatitidis. DNA sequencing confirmed the diagnosis. B. dermatitidis should be considered in the differential diagnosis of pulmonary disease in llamas.

scholarly journals Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics

2020 ◽  
Author(s):  
Kiyomi Morita ◽  
Feng Wang ◽  
Katharina Jahn ◽  
Jack Kuipers ◽  
Yuanqing Yan ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Dna Sequencing ◽  
Single Cell ◽  
High Throughput ◽  
Myeloid Leukemia ◽  
Clonal Evolution ◽  
Treatment Resistance ◽  
Clonal Diversity ◽  
History Of ◽  
Acute Myeloid

SummaryOne of the pervasive features of cancer is the diversity of mutations found in malignant cells within the same tumor; a phenomenon called clonal diversity or intratumor heterogeneity. Clonal diversity allows tumors to adapt to the selective pressure of treatment and likely contributes to the development of treatment resistance and cancer recurrence. Thus, the ability to precisely delineate the clonal substructure of a tumor, including the evolutionary history of its development and the co-occurrence of its mutations, is necessary to understand and overcome treatment resistance. However, DNA sequencing of bulk tumor samples cannot accurately resolve complex clonal architectures. Here, we performed high-throughput single-cell DNA sequencing to quantitatively assess the clonal architecture of acute myeloid leukemia (AML). We sequenced a total of 556,951 cells from 77 patients with AML for 19 genes known to be recurrently mutated in AML. The data revealed clonal relationship among AML driver mutations and identified mutations that often co-occurred (e.g., NPM1/FLT3-ITD, DNMT3A/NPM1, SRSF2/IDH2, and WT1/FLT3-ITD) and those that were mutually exclusive (e.g., NRAS/KRAS, FLT3-D835/ITD, and IDH1/IDH2) at single-cell resolution. Reconstruction of the tumor phylogeny uncovered history of tumor development that is characterized by linear and branching clonal evolution patterns with latter involving functional convergence of separately evolved clones. Analysis of longitudinal samples revealed remodeling of clonal architecture in response to therapeutic pressure that is driven by clonal selection. Furthermore, in this AML cohort, higher clonal diversity (≥4 subclones) was associated with significantly worse overall survival. These data portray clonal relationship, architecture, and evolution of AML driver genes with unprecedented resolution, and illuminate the role of clonal diversity in therapeutic resistance, relapse and clinical outcome in AML.

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