scholarly journals Pulsatile GnRH therapy in CCPHD

2017 ◽  
Vol 13 (6) ◽  
pp. 315-315
Author(s):  
Claire Greenhill
Keyword(s):  
Pulsatile Gnrh ◽  
Gnrh Therapy

Non-responsiveness of serum gonadotropins and testosterone to pulsatile GnRH in hemochromatosis suggesting a pituitary defect

1993 ◽  
Vol 128 (4) ◽  
pp. 351-354 ◽  
Author(s):  
Lise Duranteau ◽  
Philippe Chanson ◽  
Joelle Blumberg-Tick ◽  
Guy Thomas ◽  
Sylvie Brailly ◽  
...  
Keyword(s):  
Single Pulse ◽  
Serum Testosterone ◽  
Pulse Amplitude ◽  
Pulse Frequency ◽  
Gonadotropin Secretion ◽  
Pulsatile Gnrh ◽  
Serum Lh ◽  
Before And After ◽  
Gnrh Therapy ◽  
Lh Secretion

We investigated the potential pituitary origin of gonadal insufficiency in hemochromatosis. Gonadotropin secretion was studied in seven patients with hemochromatosis and hypogonadism, before and after chronic pulsatile GnRH therapy. Pulsatile LH secretion was studied before (sampling every 10 min for 6 h) and after 15-30 days of chronic pulsatile GnRH therapy (10-12 μg per pulse). Prior to GnRH therapy, all the patients had low serum testosterone, FSH and LH levels. LH secretion was non-pulsatile in four patients, while a single pulse was detected in the remaining three. Chronic pulsatile GnRH administration did not increase serum testosterone levels; similarly, serum LH levels remained low: neither pulse frequency nor pulse amplitude was modified. We conclude that hypogonadism in hemochromatosis is due to pituitary lesions.

Polycystic ovarian disease unmasked by pulsatile GnRH therapy in a subgroup of women with hypothalamic amenorrhea

2008 ◽  
Vol 89 (2) ◽  
pp. 404-409 ◽  
Author(s):  
Verena Mattle ◽  
Aysen Bilgyicildirim ◽  
Dijana Hadziomerovic ◽  
Helmut W. Ott ◽  
Ioannis Zervomanolakis ◽  
...  
Keyword(s):  
Hypothalamic Amenorrhea ◽  
Polycystic Ovarian Disease ◽  
Ovarian Disease ◽  
Pulsatile Gnrh ◽  
Gnrh Therapy

The effect of long-term pulsatile GnRH administration on the 24-hour integrated concentration of GH in hypogonadotropic hypogonadic patients

1989 ◽  
Vol 120 (6) ◽  
pp. 724-728 ◽  
Author(s):  
M. Giusti ◽  
R. Torre ◽  
P. Cavagnaro ◽  
R. Attanasio ◽  
L. Traverso ◽  
...  
Keyword(s):  
Sex Steroids ◽  
Sex Steroid ◽  
Hormonal Secretion ◽  
Pulsatile Gnrh ◽  
Pulsatile Administration ◽  
17Β Estradiol ◽  
Gnrh Therapy

Abstract. Measurement of integrated concentration of GH by means of continuous withdrawal sampling is a method of evaluating physiological hormonal secretion. Integrated concentration of GH was evaluated in 5 subjects with idiopathic hypogonadal hypogonadism (range 19–27 years) and in a 17-year-old male with idiopathic delay of puberty (5 males, 1 female) before and 30–240 days after the start of pulsatile GnRH administration. Gonadotropins and testosterone or 17β-estradiol were restored, whereas 24-h integrated concentration of GH (before therapy 5.4 ± 1.3 IU/l; during GnRH 8.1 ± 2.0 IU/l; P< 0.05) was increased by GnRH therapy. However, no correlation was found between GH levels and sex steroid concentrations during GnRH pulsatile administration. These data further confirm that a physiological increase in gonadotropins and sex steroids can modulate GH synthesis and/or release.

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