scholarly journals Tumour cell invasion: an emerging role for basal epithelial cell extrusion

2014 ◽  
Vol 14 (7) ◽  
pp. 495-501 ◽  
Author(s):  
Gloria M. Slattum ◽  
Jody Rosenblatt
Keyword(s):  
Epithelial Cell ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Basal Epithelial Cell ◽  
Tumour Cell Invasion ◽  
Cell Extrusion

scholarly journals Cleavage of Extracellular Matrix Molecules: a role for ADAM8 in tumour cell invasion

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Taheera Ferdous ◽  
Panagiota Golfi ◽  
Uwe Schlomann ◽  
Marc D Zack ◽  
Joerg W Bartsch
Keyword(s):  
Extracellular Matrix ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Extracellular Matrix Molecules ◽  
Tumour Cell Invasion

scholarly journals CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2963
Author(s):  
Jason C. Fleming ◽  
Jeongmin Woo ◽  
Karwan Moutasim ◽  
Christopher J. Hanley ◽  
Steven J. Frampton ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cell Invasion ◽  
Tumour Cell ◽  
3D Culture ◽  
Response To Therapy ◽  
Antibody Array ◽  
Hpv Status ◽  
Tumour Cell Invasion

Head and neck squamous cell carcinoma (HNSCC) is a heterogenous disease treated with surgery and/or (chemo) radiotherapy, but up to 50% of patients with late-stage disease develop locoregional recurrence. Determining the mechanisms underpinning treatment resistance could identify new therapeutic targets and aid treatment selection. C-terminal tensin-like (CTEN) is a member of the tensin family, upregulated in several cancers, although its expression and function in HNSCC are unknown. We found that CTEN is commonly upregulated in HNSCC, particularly HPV−ve tumours. In vitro CTEN was upregulated in HPV−ve (n = 5) and HPV+ve (n = 2) HNSCC cell lines. Stable shRNA knockdown of CTEN in vivo significantly reduced tumour growth (SCC-25), and functional analyses in vitro showed that CTEN promoted tumour cell invasion, colony formation and growth in 3D-culture (SCC-25, Detroit 562). RNA sequencing of SCC-25 cells following CTEN siRNA knockdown identified 349 differentially expressed genes (logFC > 1, p < 0.05). Gene ontology analysis highlighted terms relating to cell locomotion and apoptosis, consistent with in vitro findings. A membrane-based antibody array confirmed that CTEN regulated multiple apoptosis-associated proteins, including HSP60 and cleaved caspase-3. Notably, in a mixed cohort of HPV+ve and HPV−ve HNSCC patients (n = 259), we found a significant, independent negative association of CTEN with prognosis, limited to those patients treated with (chemo)radiotherapy, not surgery, irrespective of human papillomavirus (HPV) status. These data show that CTEN is commonly upregulated in HNSCC and exerts several functional effects. Its potential role in modulating apoptotic response to therapy suggests utility as a predictive biomarker or radio-sensitising target.

A New In-Vitro Model to Study Tumour Cell Invasion

Metastasis ◽  
1980 ◽  
pp. 28-32 ◽  
Author(s):  
R. Tchao ◽  
A. B. Schleich ◽  
M. Frick ◽  
A. Mayer
Keyword(s):  
Cell Invasion ◽  
Tumour Cell ◽  
In Vitro Model ◽  
Tumour Cell Invasion ◽  
Vitro Model

scholarly journals Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion

2002 ◽  
Vol 86 (8) ◽  
pp. 1310-1315 ◽  
Author(s):  
A Siegert ◽  
C Rosenberg ◽  
W D Schmitt ◽  
C Denkert ◽  
S Hauptmann
Keyword(s):  
Nitric Oxide ◽  
Cell Lines ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Colorectal Adenocarcinoma ◽  
Adenocarcinoma Cell ◽  
Tumour Cell Invasion

scholarly journals Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration

2015 ◽  
Vol 11 (11) ◽  
pp. e1004571 ◽  
Author(s):  
David P. A. Cohen ◽  
Loredana Martignetti ◽  
Sylvie Robine ◽  
Emmanuel Barillot ◽  
Andrei Zinovyev ◽  
...  
Keyword(s):  
Mathematical Modelling ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Molecular Pathways ◽  
Invasion And Migration ◽  
Tumour Cell Invasion ◽  
And Migration

scholarly journals The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion

EMBO Reports ◽  
2011 ◽  
Vol 12 (9) ◽  
pp. 931-937 ◽  
Author(s):  
Ernst J A Steller ◽  
Laila Ritsma ◽  
Danielle A E Raats ◽  
Frederik J H Hoogwater ◽  
Benjamin L Emmink ◽  
...  
Keyword(s):  
Cell Invasion ◽  
Tumour Cell ◽  
Death Receptor ◽  
Tumour Cell Invasion
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