scholarly journals Human lymphatic endothelial cells contribute to epithelial ovarian carcinoma metastasis by promoting lymphangiogenesis and tumour cell invasion

2016 ◽  
Vol 11 (5) ◽  
pp. 1587-1594 ◽  
Author(s):  
YIHONG XIE ◽  
YANPING ZHONG ◽  
TING GAO ◽  
XINYING ZHANG ◽  
LI LI ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Ovarian Carcinoma ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Epithelial Ovarian Carcinoma ◽  
Lymphatic Endothelial Cells ◽  
Tumour Cell Invasion ◽  
Carcinoma Metastasis

scholarly journals Cleavage of Extracellular Matrix Molecules: a role for ADAM8 in tumour cell invasion

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Taheera Ferdous ◽  
Panagiota Golfi ◽  
Uwe Schlomann ◽  
Marc D Zack ◽  
Joerg W Bartsch
Keyword(s):  
Extracellular Matrix ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Extracellular Matrix Molecules ◽  
Tumour Cell Invasion

scholarly journals CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2963
Author(s):  
Jason C. Fleming ◽  
Jeongmin Woo ◽  
Karwan Moutasim ◽  
Christopher J. Hanley ◽  
Steven J. Frampton ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cell Invasion ◽  
Tumour Cell ◽  
3D Culture ◽  
Response To Therapy ◽  
Antibody Array ◽  
Hpv Status ◽  
Tumour Cell Invasion

Head and neck squamous cell carcinoma (HNSCC) is a heterogenous disease treated with surgery and/or (chemo) radiotherapy, but up to 50% of patients with late-stage disease develop locoregional recurrence. Determining the mechanisms underpinning treatment resistance could identify new therapeutic targets and aid treatment selection. C-terminal tensin-like (CTEN) is a member of the tensin family, upregulated in several cancers, although its expression and function in HNSCC are unknown. We found that CTEN is commonly upregulated in HNSCC, particularly HPV−ve tumours. In vitro CTEN was upregulated in HPV−ve (n = 5) and HPV+ve (n = 2) HNSCC cell lines. Stable shRNA knockdown of CTEN in vivo significantly reduced tumour growth (SCC-25), and functional analyses in vitro showed that CTEN promoted tumour cell invasion, colony formation and growth in 3D-culture (SCC-25, Detroit 562). RNA sequencing of SCC-25 cells following CTEN siRNA knockdown identified 349 differentially expressed genes (logFC > 1, p < 0.05). Gene ontology analysis highlighted terms relating to cell locomotion and apoptosis, consistent with in vitro findings. A membrane-based antibody array confirmed that CTEN regulated multiple apoptosis-associated proteins, including HSP60 and cleaved caspase-3. Notably, in a mixed cohort of HPV+ve and HPV−ve HNSCC patients (n = 259), we found a significant, independent negative association of CTEN with prognosis, limited to those patients treated with (chemo)radiotherapy, not surgery, irrespective of human papillomavirus (HPV) status. These data show that CTEN is commonly upregulated in HNSCC and exerts several functional effects. Its potential role in modulating apoptotic response to therapy suggests utility as a predictive biomarker or radio-sensitising target.

A New In-Vitro Model to Study Tumour Cell Invasion

Metastasis ◽  
1980 ◽  
pp. 28-32 ◽  
Author(s):  
R. Tchao ◽  
A. B. Schleich ◽  
M. Frick ◽  
A. Mayer
Keyword(s):  
Cell Invasion ◽  
Tumour Cell ◽  
In Vitro Model ◽  
Tumour Cell Invasion ◽  
Vitro Model

scholarly journals Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion

2002 ◽  
Vol 86 (8) ◽  
pp. 1310-1315 ◽  
Author(s):  
A Siegert ◽  
C Rosenberg ◽  
W D Schmitt ◽  
C Denkert ◽  
S Hauptmann
Keyword(s):  
Nitric Oxide ◽  
Cell Lines ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Colorectal Adenocarcinoma ◽  
Adenocarcinoma Cell ◽  
Tumour Cell Invasion

LAPTM4B overexpression is a novel predictor of epithelial ovarian carcinoma metastasis

2010 ◽  
Vol 129 (3) ◽  
pp. 629-635 ◽  
Author(s):  
Mingzhu Yin ◽  
Ye Xu ◽  
Ge Lou ◽  
Yan Hou ◽  
Fanling Meng ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Epithelial Ovarian Carcinoma ◽  
Carcinoma Metastasis
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