Fluorescent conjugated polymer-based FRET technique for detection of DNA methylation of cancer cells

2010 ◽  
Vol 5 (7) ◽  
pp. 1255-1264 ◽  
Author(s):  
Fude Feng ◽  
Libing Liu ◽  
Shu Wang
Keyword(s):  
Dna Methylation ◽  
Cancer Cells ◽  
Conjugated Polymer

scholarly journals δ EF1 associates with DNMT1 and maintains DNA methylation of the E‐cadherin promoter in breast cancer cells

2014 ◽  
Vol 4 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Akihiko Fukagawa ◽  
Hiroki Ishii ◽  
Keiji Miyazawa ◽  
Masao Saitoh
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
E Cadherin

scholarly journals Combined analysis of DNA methylation and cell cycle in cancer cells

Epigenetics ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. 82-91 ◽  
Author(s):  
Cécile Desjobert ◽  
Mounir El Maï ◽  
Tom Gérard-Hirne ◽  
Dominique Guianvarc'h ◽  
Arnaud Carrier ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Combined Analysis

scholarly journals Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns

2012 ◽  
Vol 34 (2) ◽  
pp. 248-256 ◽  
Author(s):  
C. L. Doig ◽  
P. K. Singh ◽  
V. K. Dhiman ◽  
J. L. Thorne ◽  
S. Battaglia ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Target Genes ◽  
Prostate Cancer Cells ◽  
Methylation Patterns

scholarly journals Global and gene specific DNA methylation in breast cancer cells was not affected during epithelial-to-mesenchymal transition in vitro

Neoplasma ◽  
2016 ◽  
Vol 63 (06) ◽  
pp. 901-910 ◽  
Author(s):  
B. SMOLKOVA ◽  
S. MIKLIKOVA ◽  
V. HORVATHOVA KAJABOVA ◽  
A. BABELOVA ◽  
N. EL YAMANI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition

scholarly journals Activation ofp16Gene Silenced by DNA Methylation in Cancer Cells by Phosphoramidate Derivatives of 2′-Deoxyzebularine

2008 ◽  
Vol 51 (23) ◽  
pp. 7593-7601 ◽  
Author(s):  
Christine B. Yoo ◽  
Rocco Valente ◽  
Costantino Congiatu ◽  
Federica Gavazza ◽  
Annette Angel ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cancer Cells ◽  
Derivatives Of

scholarly journals Genome-Wide Analysis of DNA Methylation and Expression of MicroRNAs in Breast Cancer Cells

2012 ◽  
Vol 13 (7) ◽  
pp. 8259-8272 ◽  
Author(s):  
Sumiyo Morita ◽  
Ryou-u Takahashi ◽  
Riu Yamashita ◽  
Atsushi Toyoda ◽  
Takuro Horii ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Genome Wide Analysis ◽  
Genome Wide

Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3

Gut ◽  
2019 ◽  
Vol 69 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Masahiro Maeda ◽  
Hideyuki Takeshima ◽  
Naoko Iida ◽  
Naoko Hattori ◽  
Satoshi Yamashita ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cell ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Stem Cell Niche ◽  
Therapeutic Targets ◽  
Prognostic Impact ◽  
Cell Growth And Migration ◽  
Cell Niche

ObjectiveCancer-associated fibroblasts (CAFs), a major component of cancer stroma, can confer aggressive properties to cancer cells by secreting multiple factors. Their phenotypes are stably maintained, but the mechanisms are not fully understood. We aimed to show the critical role of epigenetic changes in CAFs in maintaining their tumour-promoting capacity and to show the validity of the epigenomic approach in identifying therapeutic targets from CAFs to starve cancer cells.DesignTwelve pairs of primary gastric CAFs and their corresponding non-CAFs (NCAFs) were established from surgical specimens. Genome-wide DNA methylation and H3K27me3 analyses were conducted by BeadArray 450K and ChIP-on-Chip, respectively. Functions of potential a therapeutic target were analysed by inhibiting it, and prognostic impact was assessed in a database.ResultsCAFs had diverse and distinct DNA methylation and H3K27me3 patterns compared with NCAFs. Loss of H3K27me3, but not DNA methylation, in CAFs was enriched for genes involved in stem cell niche, cell growth, tissue development and stromal–epithelial interactions, such asWNT5A,GREM1,NOGandIGF2. Among these, we revealed that WNT5A, which had been considered to be derived from cancer cells, was highly expressed in cancer stromal fibroblasts, and was associated with poor prognosis. Inhibition of secreted WNT5A from CAFs suppressed cancer cell growth and migration.ConclusionsH3K27me3 plays a crucial role in defining tumour-promoting capacities of CAFs, and multiple stem cell niche factors were secreted from CAFs due to loss of H3K27me3. The validity of the epigenetic approach to uncover therapeutic targets for cancer-starving therapy was demonstrated.

scholarly journals Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells

Oncogene ◽  
2007 ◽  
Vol 26 (45) ◽  
pp. 6566-6576 ◽  
Author(s):  
A Vincent ◽  
M Perrais ◽  
J-L Desseyn ◽  
J-P Aubert ◽  
P Pigny ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cancer Cells ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Epithelial Cancer ◽  
Mucin Genes

Low Band Gap Donor-Acceptor Conjugated Polymer Nanoparticles and their NIR-mediated Thermal Ablation of Cancer Cells

2012 ◽  
Vol 13 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Christopher M. MacNeill ◽  
Robert C. Coffin ◽  
David L. Carroll ◽  
Nicole H. Levi-Polyachenko
Keyword(s):  
Band Gap ◽  
Cancer Cells ◽  
Conjugated Polymer ◽  
Thermal Ablation ◽  
Polymer Nanoparticles ◽  
Low Band Gap ◽  
Donor Acceptor ◽  
Conjugated Polymer Nanoparticles
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