scholarly journals Binding Pattern Determination Of Class of Antifungal Drugs

2010 ◽  
Author(s):  
Arpit Tandon ◽  
Arpit Tandon ◽  
A Naqvi ◽  
Nitin Chitranshi ◽  
Siddharth Sinha
Keyword(s):  
Antifungal Drugs ◽  
Binding Pattern ◽  
Pattern Determination

scholarly journals Binding Pattern Determination Of Class of Antifungal Drugs

2010 ◽  
Author(s):  
Arpit Tandon ◽  
A Naqvi ◽  
Nitin Chitranshi ◽  
Siddharth Sinha
Keyword(s):  
Antifungal Drugs ◽  
Binding Pattern ◽  
Pattern Determination

Essential oils as alternative promising anti-Candidal agents: progress and prospects

2021 ◽  
Vol 27 ◽  
Author(s):  
Awad Shala ◽  
Shweta Singh ◽  
Saif Hameed ◽  
.M.P. Khurana
Keyword(s):  
Essential Oils ◽  
Antioxidant Properties ◽  
Therapeutic Agents ◽  
Antifungal Drugs ◽  
Fungal Resistance ◽  
Antifungal Compounds ◽  
Candida Spp ◽  
Conventional Antibiotics ◽  
Opportunistic Pathogenic

: Candida albicans is one of the main agents responsible for opportunistic pathogenic infections. The progressive emergence of fungal resistance to conventional antibiotics and its side effects as well as treatment costs are considered as major limitations for antifungal drugs. It has drawn scientists' attention to search for potential substitution and therapeutic reliable alternatives for the antifungal compounds from sources like medicinal plants, which contain numerous bioactive compounds such as essential oils. Essential oils (EO) apart from having lower toxicity and better biodegradability are eco-friendly in nature as compared with conventional antibiotics. Furthermore, extracted essential oils have been reported to possess potent antimicrobial, anti-inflammatory and antioxidant properties that nominate them as natural promising candidates to combat numerous fungal ailments. Thus, determination of antifungal efficacy of essential oil-bearing plants on Candida spp. will provide miscellaneous knowledge for future clinical studies that are required for development of new formulations as alternative therapeutic agents to control the growth of Candida species. Therefore, this review summarizes the gist of major essential oils that have been investigated for their anti- Candida potential with some recommendations for further study.

scholarly journals Liquid Phase and Microwave-Assisted Extractions for Multicomponent Phenolic Pattern Determination of Five Romanian Galium Species Coupled with Bioassays

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1226 ◽  
Author(s):  
Andrei Mocan ◽  
Alina Diuzheva ◽  
Sabin Bădărău ◽  
Cadmiel Moldovan ◽  
Vasil Andruch ◽  
...  
Keyword(s):  
Liquid Phase ◽  
Iridoid Glycosides ◽  
Deep Eutectic Solvent ◽  
Inhibitory Effect ◽  
Total Phenolic ◽  
Extraction Solvent ◽  
Microwave Assisted ◽  
Pattern Determination ◽  
Natural Deep Eutectic Solvent

Background: Galium is a plant rich in iridoid glycosides, flavonoids, anthraquinones, and small amounts of essential oils and vitamin C. Recent works showed the antibacterial, antifungal, antiparasitic, and antioxidant activity of this plant genus. Methods: For the determination of the multicomponent phenolic pattern, liquid phase microextraction procedures were applied, combined with HPLC-PDA instrument configuration in five Galium species aerial parts (G. verum, G. album, G. rivale, G. pseudoaristatum, and G. purpureum). Dispersive Liquid–Liquid MicroExtraction (DLLME) with NaCl and NAtural Deep Eutectic Solvent (NADES) medium and Ultrasound-Assisted (UA)-DLLME with β-cyclodextrin medium were optimized. Results: The optimal DLLME conditions were found to be: 10 mg of the sample, 10% NaCl, 15% NADES or 1% β-cyclodextrin as extraction solvent—400 μL of ethyl acetate as dispersive solvent—300 μL of ethanol, vortex time—30 s, extraction time—1 min, centrifugation at 12000× g for 5 min. Conclusions: These results were compared with microwave-assisted extraction procedures. G. purpureum and G. verum extracts showed the highest total phenolic and flavonoid content, respectively. The most potent extract in terms of antioxidant capacity was obtained from G. purpureum, whereas the extract obtained from G. album exhibited the strongest inhibitory effect against tyrosinase.

Determination of susceptibility/resistance to antifungal drugs ofTrichophyton mentagrophytesisolates by a macrodilution method

2005 ◽  
Vol 51 (11) ◽  
pp. 983-987 ◽  
Author(s):  
Maria Elisabete da Silva Barros ◽  
Júnia Soares Hamdan
Keyword(s):  
Human Population ◽  
Culture Medium ◽  
Susceptibility Testing ◽  
Trichophyton Mentagrophytes ◽  
Antifungal Drugs ◽  
The Other ◽  
Minimal Inhibitory Concentrations ◽  
Adult Human

Onychomycosis is a common adult human mycosis, and dermatophytes of the Trichophyton genera are the most frequently isolated microorganism. Globally, from 3% to 10% of the human population is attacked by ony cho mycosis, and many cases involve toenails. The aim of this work was to determine the minimal inhibitory concentrations (MICs) of antifungal drugs (fluconazole, ketoconazole, itraconazole, terbinafine, and griseofulvin) often used for the treatment of ungueal dermatophytosis caused by Trichophyton mentagrophytes. The MICs were determined by the broth medium macrodilution method. The results showed that activities of terbinafine and itraconazole were significantly higher (MIC <0.007–0.015 µg·mL–1and MIC = 0.062–1.000 µg·mL–1, respectively). All isolates had reduced susceptibility to fluconazole (MIC = 16 to >64 µg·mL–1). The MICs of ketoconazole and griseofulvin varied among strains, ranging from 0.125 to 2.000 µg·mL–1for ketoconazole and from 0.25 to 2.00 µg·mL–1for griseofulvin. These MICs were higher than those of other studies cited, possibly because of differences in culture medium used in the other studies.Key words: dermatophytes, susceptibility testing, macrodilution, onychomycosis, antifungal drugs.

Detection and substitution-pattern determination of guanidines

1976 ◽  
Vol 32 (3) ◽  
pp. 284-285
Author(s):  
Renée A. Corral ◽  
O. O. Orazi ◽  
María E. González
Keyword(s):  
Substitution Pattern ◽  
Pattern Determination

scholarly journals Sphingolipid biosynthetic pathway is crucial for growth, biofilm formation and membrane integrity of Scedosporium boydii

2019 ◽  
Vol 11 (22) ◽  
pp. 2905-2917 ◽  
Author(s):  
Rodrigo Rollin-Pinheiro ◽  
Victor Pereira Rochetti ◽  
Mariana Ingrid Dutra da Silva Xisto ◽  
Livia Cristina Liporagi-Lopes ◽  
Beatriz Bastos ◽  
...  
Keyword(s):  
Cell Biology ◽  
Pathogenic Fungus ◽  
Membrane Integrity ◽  
Fungal Growth ◽  
Antifungal Drugs ◽  
Wide Range ◽  
Antifungal Potential ◽  
Sphingolipid Biosynthesis ◽  
Increased Susceptibility

Aim: Glycosphingolipids are conserved lipids displaying a variety of functions in fungal cells, such as determination of cell polarity and virulence. They have been considered as potent targets for new antifungal drugs. The present work aimed to test two inhibitors, myriocin and DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol, in Scedosporium boydii, a pathogenic fungus which causes a wide range of disease. Materials & methods: Mass spectrometry, microscopy and cell biology approaches showed that treatment with both inhibitors led to defects in fungal growth and membrane integrity, and caused an increased susceptibility to the current antifungal agents. Conclusion: These data demonstrate the antifungal potential of drugs inhibiting sphingolipid biosynthesis, as well as the usefulness of sphingolipids as promising targets for the development of new therapeutic options.

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