scholarly journals Glucagon-Like Peptide-1 Receptor Signaling in the Lateral Dorsal Tegmental Nucleus Regulates Energy Balance

2017 ◽  
Vol 43 (3) ◽  
pp. 627-637 ◽  
Author(s):  
David J Reiner ◽  
Rosa M Leon ◽  
Lauren E McGrath ◽  
Kieran Koch-Laskowski ◽  
Joel D Hahn ◽  
...  
Keyword(s):  
Energy Balance ◽  
Receptor Signaling ◽  
Tegmental Nucleus ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Dorsal Tegmental Nucleus

Differential Importance of Glucose-Dependent Insulinotropic Polypeptide vs Glucagon-Like Peptide 1 Receptor Signaling for Beta Cell Survival in Mice

2009 ◽  
Vol 137 (6) ◽  
pp. 2146-2157 ◽  
Author(s):  
Adriano Maida ◽  
Tanya Hansotia ◽  
Christine Longuet ◽  
Yutaka Seino ◽  
Daniel J. Drucker
Keyword(s):  
Beta Cell ◽  
Cell Survival ◽  
Receptor Signaling ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus–induced type 2 responses and immunopathology

2018 ◽  
Vol 142 (2) ◽  
pp. 683-687.e12 ◽  
Author(s):  
Melissa H. Bloodworth ◽  
Mark Rusznak ◽  
Connor C. Pfister ◽  
Jian Zhang ◽  
Lisa Bastarache ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Receptor Signaling ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Syncytial Virus

Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus

2019 ◽  
Vol 109 (4) ◽  
pp. 310-321 ◽  
Author(s):  
Fredrik Anesten ◽  
Devesh Mishra ◽  
Adrià Dalmau Gasull ◽  
Linda Engström-Ruud ◽  
Jakob Bellman ◽  
...  
Keyword(s):  
Energy Balance ◽  
Mrna Level ◽  
Intraperitoneal Administration ◽  
Receptor Activation ◽  
Parabrachial Nucleus ◽  
Differentiation Factor ◽  
Lateral Parabrachial Nucleus ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Anorexigenic Peptide

Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucagon neurons in the nucleus of the solitary tract. These neurons innervate energy balance-regulating areas, such as the external lateral parabrachial nucleus (PBNel); essential for induction of anorexia. Using a validated novel IL-6-reporter mouse strain, we investigated the interactions in PBNel between GLP-1, IL-6, and calcitonin gene-related peptide (CGRP, a well-known mediator of anorexia). We show that PBNel GLP-1R-containing cells highly (to about 80%) overlap with IL-6-containing cells on both protein and mRNA level. Intraperitoneal administration of a GLP-1 analogue exendin-4 to mice increased the proportion of IL-6-containing cells in PBNel 3-fold, while there was no effect in the rest of the lateral parabrachial nucleus. In contrast, injections of an anorexigenic peptide growth and differentiation factor 15 (GDF15) markedly increased the proportion of CGRP-containing cells, while IL-6-containing cells were not affected. In summary, GLP-1R are found on IL-6-producing cells in PBNel, and GLP-1R stimulation leads to an increase in the proportion of cells with IL-6-reporter fluorescence, supporting IL-6 mediation of GLP-1 effects on energy balance.

Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice

2001 ◽  
Vol 438 (4) ◽  
pp. 382-387 ◽  
Author(s):  
Z. Ling ◽  
D. Wu ◽  
Y. Zambre ◽  
D. Flamez ◽  
D.J. Drucker ◽  
...  
Keyword(s):  
Islet Cells ◽  
Receptor Signaling ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors

2013 ◽  
Vol 305 (11) ◽  
pp. E1367-E1374 ◽  
Author(s):  
Elizabeth G. Mietlicki-Baase ◽  
Pavel I. Ortinski ◽  
Laura E. Rupprecht ◽  
Diana R. Olivos ◽  
Amber L. Alhadeff ◽  
...  
Keyword(s):  
Food Intake ◽  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Kainate Receptors ◽  
System Control ◽  
Receptor Signaling ◽  
Palatable Food ◽  
Glucagon Like Peptide ◽  
Ventral Tegmental ◽  
Glucagon Like Peptide 1

Glucagon-like peptide-1 receptor (GLP-1R) activation in the ventral tegmental area (VTA) is physiologically relevant for the control of palatable food intake. Here, we tested whether the food intake-suppressive effects of VTA GLP-1R activation are mediated by glutamatergic signaling within the VTA. Intra-VTA injections of the GLP-1R agonist exendin-4 (Ex-4) reduced palatable high-fat food intake in rats primarily by reducing meal size; these effects were mediated in part via glutamatergic AMPA/kainate but not NMDA receptor signaling. Additional behavioral data indicated that GLP-1R expressed specifically within the VTA can partially mediate the intake- and body weight-suppressive effects of systemically administered Ex-4, offering the intriguing possibility that this receptor population may be clinically relevant for food intake control. Intra-VTA Ex-4 rapidly increased tyrosine hydroxylase levels within the VTA, suggesting that GLP-1R activation modulates VTA dopaminergic signaling. Further evidence for this hypothesis was provided by electrophysiological data showing that Ex-4 increased the frequency of AMPA-mediated currents and reduced the paired/pulse ratio in VTA dopamine neurons. Together, these data provide novel mechanisms by which GLP-1R agonists in the mesolimbic reward system control for palatable food intake.

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