Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice

2001 ◽  
Vol 438 (4) ◽  
pp. 382-387 ◽  
Author(s):  
Z. Ling ◽  
D. Wu ◽  
Y. Zambre ◽  
D. Flamez ◽  
D.J. Drucker ◽  
...  
Keyword(s):  
Islet Cells ◽  
Receptor Signaling ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals The Rap–B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells

Diabetologia ◽  
2005 ◽  
Vol 48 (8) ◽  
pp. 1534-1540 ◽  
Author(s):  
J. Trümper ◽  
D. Ross ◽  
H. Jahr ◽  
M. D. Brendel ◽  
R. Göke ◽  
...  
Keyword(s):  
Islet Cells ◽  
Human Islet ◽  
Signalling Pathway ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Differential Importance of Glucose-Dependent Insulinotropic Polypeptide vs Glucagon-Like Peptide 1 Receptor Signaling for Beta Cell Survival in Mice

2009 ◽  
Vol 137 (6) ◽  
pp. 2146-2157 ◽  
Author(s):  
Adriano Maida ◽  
Tanya Hansotia ◽  
Christine Longuet ◽  
Yutaka Seino ◽  
Daniel J. Drucker
Keyword(s):  
Beta Cell ◽  
Cell Survival ◽  
Receptor Signaling ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus–induced type 2 responses and immunopathology

2018 ◽  
Vol 142 (2) ◽  
pp. 683-687.e12 ◽  
Author(s):  
Melissa H. Bloodworth ◽  
Mark Rusznak ◽  
Connor C. Pfister ◽  
Jian Zhang ◽  
Lisa Bastarache ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Receptor Signaling ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Syncytial Virus

scholarly journals The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors

2013 ◽  
Vol 305 (11) ◽  
pp. E1367-E1374 ◽  
Author(s):  
Elizabeth G. Mietlicki-Baase ◽  
Pavel I. Ortinski ◽  
Laura E. Rupprecht ◽  
Diana R. Olivos ◽  
Amber L. Alhadeff ◽  
...  
Keyword(s):  
Food Intake ◽  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Kainate Receptors ◽  
System Control ◽  
Receptor Signaling ◽  
Palatable Food ◽  
Glucagon Like Peptide ◽  
Ventral Tegmental ◽  
Glucagon Like Peptide 1

Glucagon-like peptide-1 receptor (GLP-1R) activation in the ventral tegmental area (VTA) is physiologically relevant for the control of palatable food intake. Here, we tested whether the food intake-suppressive effects of VTA GLP-1R activation are mediated by glutamatergic signaling within the VTA. Intra-VTA injections of the GLP-1R agonist exendin-4 (Ex-4) reduced palatable high-fat food intake in rats primarily by reducing meal size; these effects were mediated in part via glutamatergic AMPA/kainate but not NMDA receptor signaling. Additional behavioral data indicated that GLP-1R expressed specifically within the VTA can partially mediate the intake- and body weight-suppressive effects of systemically administered Ex-4, offering the intriguing possibility that this receptor population may be clinically relevant for food intake control. Intra-VTA Ex-4 rapidly increased tyrosine hydroxylase levels within the VTA, suggesting that GLP-1R activation modulates VTA dopaminergic signaling. Further evidence for this hypothesis was provided by electrophysiological data showing that Ex-4 increased the frequency of AMPA-mediated currents and reduced the paired/pulse ratio in VTA dopamine neurons. Together, these data provide novel mechanisms by which GLP-1R agonists in the mesolimbic reward system control for palatable food intake.

Central & peripheral glucagon-like peptide-1 receptor signaling differentially regulate addictive behaviors

2016 ◽  
Vol 161 ◽  
pp. 140-144 ◽  
Author(s):  
Sunil Sirohi ◽  
Jennifer D. Schurdak ◽  
Randy J. Seeley ◽  
Stephen C. Benoit ◽  
Jon F. Davis
Keyword(s):  
Addictive Behaviors ◽  
Receptor Signaling ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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