scholarly journals Erratum: Functional Uncoupling NMDAR NR2A Subunit from PSD-95 in the Prefrontal Cortex: Effects on Behavioral Dysfunction and Parvalbumin Loss after Early-Life Stress

2016 ◽  
Vol 41 (4) ◽  
pp. 1188-1188 ◽  
Author(s):  
Prabarna Ganguly ◽  
Freedom H Holland ◽  
Heather C Brenhouse
Keyword(s):  
Prefrontal Cortex ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Behavioral Dysfunction ◽  
Nr2a Subunit

scholarly journals Maternal Depression, Child Temperament, and Early-Life Stress Predict Never-Depressed Preadolescents’ Functional Connectivity During a Negative-Mood Induction

2021 ◽  
pp. 216770262110164
Author(s):  
Pan Liu ◽  
Matthew R. J. Vandermeer ◽  
Ola Mohamed Ali ◽  
Andrew R. Daoust ◽  
Marc F. Joanisse ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Maternal Depression ◽  
Life Stress ◽  
Early Life ◽  
Negative Emotion ◽  
Negative Mood ◽  
Emotion Processing ◽  
Early Life Stress ◽  
Cingulate Cortex

Understanding the development of depression can inform etiology and prevention/intervention. Maternal depression and maladaptive patterns of temperament (e.g., low positive emotionality [PE] or high negative emotionality, especially sadness) are known to predict depression. Although it is unclear how these risks cause depression, altered functional connectivity (FC) during negative-emotion processing may play an important role. We investigated whether maternal depression and age-3 emotionality predicted FC during negative mood reactivity in never-depressed preadolescents and whether these relationships were augmented by early-life stress. Maternal depression predicted decreased medial prefrontal cortex (mPFC)–amygdala and mPFC–insula FC but increased mPFC–posterior cingulate cortex (PCC) FC. PE predicted increased dorsolateral prefrontal cortex–amygdala FC, whereas sadness predicted increased PCC-based FC in insula, orbitofrontal cortex, and anterior cingulate cortex (ACC). Sadness was more strongly associated with PCC–insula and PCC–ACC FC as early stress increased. Findings indicate that early depression risks may be mediated by FC underlying negative-emotion processing.

Impact of early-life stress on the medial prefrontal cortex functions – a search for the pathomechanisms of anxiety and mood disorders

2013 ◽  
Vol 65 (6) ◽  
pp. 1462-1470 ◽  
Author(s):  
Agnieszka Chocyk ◽  
Iwona Majcher-Maślanka ◽  
Dorota Dudys ◽  
Aleksandra Przyborowska ◽  
Krzysztof Wędzony
Keyword(s):  
Prefrontal Cortex ◽  
Mood Disorders ◽  
Medial Prefrontal Cortex ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

The effects of early life stress on the excitatory/inhibitory balance of the medial prefrontal cortex

2020 ◽  
Vol 379 ◽  
pp. 112306 ◽  
Author(s):  
Ken-ichi Ohta ◽  
Shingo Suzuki ◽  
Katsuhiko Warita ◽  
Kazunori Sumitani ◽  
Chiaki Tenkumo ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

scholarly journals Sex-Specific Effects of Early Life Stress on Brain Mitochondrial Function, Monoamine Levels and Neuroinflammation

2020 ◽  
Vol 10 (7) ◽  
pp. 447 ◽  
Author(s):  
Héctor González-Pardo ◽  
Jorge L. Arias ◽  
Eneritz Gómez-Lázaro ◽  
Isabel López Taboada ◽  
Nélida M. Conejo
Keyword(s):  
Sex Differences ◽  
Prefrontal Cortex ◽  
Mitochondrial Function ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Female Rats ◽  
Dopamine Turnover ◽  
Mitochondrial Energy Metabolism ◽  
Brain Mitochondrial Function

Sex differences have been reported in the susceptibility to early life stress and its neurobiological correlates in humans and experimental animals. However, most of the current research with animal models of early stress has been performed mainly in males. In the present study, prolonged maternal separation (MS) paradigm was applied as an animal model to resemble the effects of adverse early experiences in male and female rats. Regional brain mitochondrial function, monoaminergic activity, and neuroinflammation were evaluated as adults. Mitochondrial energy metabolism was greatly decreased in MS females as compared with MS males in the prefrontal cortex, dorsal hippocampus, and the nucleus accumbens shell. In addition, MS males had lower serotonin levels and increased serotonin turnover in the prefrontal cortex and the hippocampus. However, MS females showed increased dopamine turnover in the prefrontal cortex and increased norepinephrine turnover in the striatum, but decreased dopamine turnover in the hippocampus. Sex differences were also found for pro-inflammatory cytokine levels, with increased levels of TNF-α and IL-6 in the prefrontal cortex and hippocampus of MS males, and increased IL-6 levels in the striatum of MS females. These results evidence the complex sex- and brain region-specific long-term consequences of early life stress.

scholarly journals Dysregulation of the mesoprefrontal dopamine circuit mediates an early-life stress-induced synaptic imbalance in the prefrontal cortex

Cell Reports ◽  
2021 ◽  
Vol 35 (5) ◽  
pp. 109074
Author(s):  
Won Chan Oh ◽  
Gabriela Rodríguez ◽  
Douglas Asede ◽  
Kanghoon Jung ◽  
In-Wook Hwang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress
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