scholarly journals Vulnerable and resilient cognitive performance related to early life stress: The potential mediating role of dopaminergic receptors in the medial prefrontal cortex of adult mice

2020 ◽  
Vol 80 (1) ◽  
pp. 13-27
Author(s):  
Saulo G. Tractenberg ◽  
Rodrigo Orso ◽  
Kerstin C. Creutzberg ◽  
Luiza M. C. Malcon ◽  
Francisco S. Lumertz ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Cognitive Performance ◽  
Medial Prefrontal Cortex ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Dopaminergic Receptors ◽  
Mediating Role ◽  
Adult Mice

Impact of early-life stress on the medial prefrontal cortex functions – a search for the pathomechanisms of anxiety and mood disorders

2013 ◽  
Vol 65 (6) ◽  
pp. 1462-1470 ◽  
Author(s):  
Agnieszka Chocyk ◽  
Iwona Majcher-Maślanka ◽  
Dorota Dudys ◽  
Aleksandra Przyborowska ◽  
Krzysztof Wędzony
Keyword(s):  
Prefrontal Cortex ◽  
Mood Disorders ◽  
Medial Prefrontal Cortex ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

The effects of early life stress on the excitatory/inhibitory balance of the medial prefrontal cortex

2020 ◽  
Vol 379 ◽  
pp. 112306 ◽  
Author(s):  
Ken-ichi Ohta ◽  
Shingo Suzuki ◽  
Katsuhiko Warita ◽  
Kazunori Sumitani ◽  
Chiaki Tenkumo ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress

scholarly journals Elevated fear responses to threatening cues in rats with early life stress is associated with greater excitability and loss of gamma oscillations in ventral-medial prefrontal cortex

2021 ◽  
Author(s):  
Florencia M Bercum ◽  
Maria Jose Navarro Gomez ◽  
Michael P Saddoris
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Conditioned Suppression ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Gamma Oscillations ◽  
Brain Maturation ◽  
Ventral Medial Prefrontal Cortex

Stress experienced early in development can have profound influences on developmental trajectories and ultimately behaviors in adulthood. Potent stressors during brain maturation can profoundly disrupt prefrontal cortical areas in particular, which can set the stage for prefrontal-dependent alterations in fear regulation and risk of drug abuse in adulthood. Despite these observations, few studies have investigated in vivo signaling in prefrontal signals in animals with a history of early life stress (ELS). Here, rats with ELS experience on PND3-5 were then tested on a conditioned suppression paradigm during adulthood. During conditioned suppression, electrophysiological recordings were made in the ventral medial prefrontal cortex (vmPFC) during presentations of a fear-associated cues that resolved both single-unit activity and local field potentials (LFPs). Relative to unstressed controls, ELS-experienced rats showed greater fear-related suppression of lever pressing. During presentations of the fear-associated cue (CS+), neurons in the vmPFC of ELS animals showed a significant increase in the probability of excitatory encoding relative to controls, and excitatory phasic responses in the ELS animals were reliably of higher magnitude than Controls. In contrast, vmPFC neurons in ELS subjects better discriminated between the shock-associated CS+ and the neutral ("safe") CS- cue than Controls. LFPs recorded in the same locations revealed that high gamma band (65-95 Hz) oscillations were strongly potentiated in Controls during presentation of the fear-associated CS+ cue, but this potentiation was abolished in ELS subjects. Notably, no other LFP spectra differed between ELS and Controls for either the CS+ or CS-. Collectively, these data suggest that ELS experience alters the neurobehavioral functions of PFC in adulthood that are critical for processing fear regulation. As such, these alterations may also provide insight into to increased susceptibility to other PFC-dependent processes such as risk-based choice, motivation, and regulation of drug use and relapse in ELS populations.

scholarly journals Consequences of early life stress on genomic landscape of H3K4me3 in prefrontal cortex of adult mice

BMC Genomics ◽  
2018 ◽  
Vol 19 (S3) ◽  
Author(s):  
Nikita I. Ershov ◽  
Natalya P. Bondar ◽  
Arina A. Lepeshko ◽  
Vasiliy V. Reshetnikov ◽  
Julia A. Ryabushkina ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Adult Mice ◽  
Genomic Landscape
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