scholarly journals Enhancement of Fear Extinction with Deep Brain Stimulation: Evidence for Medial Orbitofrontal Involvement

2015 ◽  
Vol 40 (7) ◽  
pp. 1726-1733 ◽  
Author(s):  
Jose Rodriguez-Romaguera ◽  
Fabricio H Do-Monte ◽  
Yoko Tanimura ◽  
Gregory J Quirk ◽  
Suzanne N Haber
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Fear Extinction ◽  
Deep Brain

scholarly journals Elevated activity in the dorsal dentate gyrus reduces expression of fear memory after fear extinction training

2021 ◽  
Vol 46 (3) ◽  
pp. E390-E401
Author(s):  
Yujie Zhang ◽  
Zongliang Wang ◽  
Jun Ju ◽  
Jianxiang Liao ◽  
Qiang Zhou
Keyword(s):  
Deep Brain Stimulation ◽  
Dentate Gyrus ◽  
Brain Stimulation ◽  
Fear Memory ◽  
Fear Extinction ◽  
Extinction Training ◽  
Local Injection ◽  
Intraventricular Injection ◽  
Lower Expression ◽  
Deep Brain

Background: Effectively reducing the expression of certain aversive memories (fear or trauma memories) with extinction training is generally viewed to be therapeutically important. A deeper understanding of the biological basis for a more effective extinction process is also of high scientific importance. Methods: Our study involved intraventricular injection or local injection into the dorsal dentate gyrus of anti-neuregulin 1 antibodies (anti-NRG1) before fear extinction training, followed by testing the expression of fear memory 24 hours afterward or 9 days later. We used local injection of chemogenetic or optogenetic viruses into the dorsal dentate gyrus to manipulate the activity of the dorsal dentate gyrus and test the expression of fear memory. We also examined the effect of deep brain stimulation in the dorsal dentate gyrus on the expression of fear memory. Results: Mice that received intraventricular injection with anti-NRG1 antibodies exhibited lower expression of fear memory and increased density of activated excitatory neurons in the dorsal dentate gyrus. Injection of anti-NRG1 antibodies directly into the dorsal dentate gyrus also led to lower expression of fear memory and more activated neurons in the dorsal dentate gyrus. Inhibiting the activity of dorsal dentate gyrus excitatory neurons using an inhibitory designer receptor exclusively activated by designer drugs (DREADD) eliminated the effects of the anti-NRG1 antibodies. Enhancing the activity of the dorsal dentate gyrus with an excitatory DREADD or optogenetic stimulation resulted in lower expression of fear memory in mice that did not receive infusion of anti-NRG1 antibodies. Deep brain stimulation in the dorsal dentate gyrus effectively suppressed expression of fear memory, both during and after fear extinction training. Limitations: The mechanism for the contribution of the dorsal dentate gyrus to the expression of fear memory needs further exploration. Conclusion: Activation of the dorsal dentate gyrus may play an important role in modulating the expression of fear memory; its potential use in fear memory extinction is worthy of further exploration.

scholarly journals Deep brain stimulation of the ventral striatum increases BDNF in the fear extinction circuit

2013 ◽  
Vol 7 ◽  
Author(s):  
Fabricio H. Do-Monte ◽  
Jose Rodriguez-Romaguera ◽  
Luis E. Rosas-Vidal ◽  
Gregory J. Quirk
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Fear Extinction ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model

2013 ◽  
Vol 64 ◽  
pp. 414-423 ◽  
Author(s):  
Nigel Whittle ◽  
Claudia Schmuckermair ◽  
Ozge Gunduz Cinar ◽  
Markus Hauschild ◽  
Francesco Ferraguti ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Mouse Model ◽  
Histone Deacetylase ◽  
Brain Stimulation ◽  
Histone Deacetylase Inhibitors ◽  
Fear Extinction ◽  
Genetic Mouse Model ◽  
Deep Brain

Nicht-medikamentöse Optionen zur Behandlung pharmakoresistenter Epilepsien

2018 ◽  
Vol 75 (7) ◽  
pp. 448-454
Author(s):  
Thomas Grunwald ◽  
Judith Kröll
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Tiefe Hirnstimulation ◽  
Ketogene Diät ◽  
Deep Brain

Zusammenfassung. Wenn mit den ersten beiden anfallspräventiven Medikamenten keine Anfallsfreiheit erzielt werden konnte, so ist die Wahrscheinlichkeit, dies mit anderen Medikamenten zu erreichen, nur noch ca. 10 %. Es sollte dann geprüft werden, warum eine Pharmakoresistenz besteht und ob ein epilepsiechirurgischer Eingriff zur Anfallsfreiheit führen kann. Ist eine solche Operation nicht möglich, so können palliative Verfahren wie die Vagus-Nerv-Stimulation (VNS) und die tiefe Hirnstimulation (Deep Brain Stimulation) in eine bessere Anfallskontrolle ermöglichen. Insbesondere bei schweren kindlichen Epilepsien stellt auch die ketogene Diät eine zu erwägende Option dar.

The Effect of Deep Brain Stimulation for Movement Disorders on Emotions

2008 ◽  
Author(s):  
Jonathan D. Richards ◽  
Paul M. Wilson ◽  
Pennie S. Seibert ◽  
Carin M. Patterson ◽  
Caitlin C. Otto ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Movement Disorders ◽  
Deep Brain

Deep Brain Stimulation Improves Medication Related Addictive Behavior and Associated Quality of Life

2009 ◽  
Author(s):  
Hunter Covert ◽  
Pennie S. Seibert ◽  
Caitlin C. Otto ◽  
Missy Coblentz ◽  
Nicole Whitener ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Addictive Behavior ◽  
Deep Brain
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