scholarly journals Resting Glutamate Levels and Rapid Glutamate Transients in the Prefrontal Cortex of the Flinders Sensitive Line Rat: A Genetic Rodent Model of Depression

2011 ◽  
Vol 36 (8) ◽  
pp. 1769-1777 ◽  
Author(s):  
Kevin N Hascup ◽  
Erin R Hascup ◽  
Michelle L Stephens ◽  
Paul EA Glaser ◽  
Takashi Yoshitake ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Rodent Model ◽  
Sensitive Line ◽  
Flinders Sensitive Line

Olfactory discrimination and memory deficits in the Flinders Sensitive Line rodent model of depression

2017 ◽  
Vol 143 ◽  
pp. 25-29
Author(s):  
A. Cook ◽  
L.-M. Pfeiffer ◽  
S. Thiele ◽  
V.A. Coenen ◽  
M.D. Döbrössy
Keyword(s):  
Memory Deficits ◽  
Rodent Model ◽  
Olfactory Discrimination ◽  
Sensitive Line ◽  
Flinders Sensitive Line

scholarly journals The long-term bio-behavioural effects of juvenile sildenafil treatment in Sprague-Dawley versus Flinders Sensitive Line rats

2021 ◽  
pp. 1-20
Author(s):  
Juandré Lambertus Bernardus Saayman ◽  
Stephanus Frederik Steyn ◽  
Christiaan Beyers Brink
Keyword(s):  
Sprague Dawley ◽  
Long Term Effects ◽  
Bdnf Level ◽  
Treatment Groups ◽  
Sd Rats ◽  
Behavioural Effects ◽  
Sensitive Line ◽  
Level Analysis ◽  
Flinders Sensitive Line

Abstract Objective: To investigate the long-term effects of juvenile sub-chronic sildenafil (SIL) treatment on the depressive-like behaviour and hippocampal brain-derived neurotrophic factor (BDNF) levels of adult Sprague-Dawley (SD) versus Flinders Sensitive Line (FSL) rats. Methods: SD and FSL rats were divided into pre-pubertal and pubertal groups, whereafter 14-day saline or SIL treatment was initiated. Pre-pubertal and pubertal rats were treated from postnatal day 21 (PND21) and PND35, respectively. The open field and forced swim tests (FST) were performed on PND60, followed by hippocampal BDNF level analysis one day later. Results: FSL rats displayed greater immobility in the FST compared to SD rats (p < 0.0001), which was reduced by SIL (p < 0.0001), regardless of treatment period. Hippocampal BDNF levels were unaltered by SIL in all treatment groups (p > 0.05). Conclusion: Juvenile sub-chronic SIL treatment reduces the risk of depressive-like behaviour manifesting during young adulthood in genetically susceptible rats.

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