Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression

Synapse ◽  
2016 ◽  
Vol 70 (11) ◽  
pp. 471-474 ◽  
Author(s):  
Giulia Treccani ◽  
Kristian Gaarn du Jardin ◽  
Gregers Wegener ◽  
Heidi Kaastrup Müller
Keyword(s):  
Prefrontal Cortex ◽  
Differential Expression ◽  
Ampa Receptor ◽  
Rat Model ◽  
Sensitive Line ◽  
Flinders Sensitive Line

Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression

2010 ◽  
Vol 34 (6) ◽  
pp. 1075-1084 ◽  
Author(s):  
Olga Kotsovolou ◽  
Magnus Ingelman-Sundberg ◽  
Matti A. Lang ◽  
Marios Marselos ◽  
David H. Overstreet ◽  
...  
Keyword(s):  
Rat Model ◽  
Hepatic Drug ◽  
Sensitive Line ◽  
Flinders Sensitive Line

scholarly journals Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: Effect of ketamine

Synapse ◽  
2016 ◽  
Vol 71 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Kristian Gaarn Du Jardin ◽  
Heidi Kaastrup Müller ◽  
Connie Sanchez ◽  
Gregers Wegener ◽  
Betina Elfving
Keyword(s):  
Gene Expression ◽  
Rat Model ◽  
Glutamatergic Neurotransmission ◽  
Depression Effect ◽  
Sensitive Line ◽  
Flinders Sensitive Line

scholarly journals Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression

2015 ◽  
Vol 40 (11) ◽  
pp. 2293-2303
Author(s):  
Helene Blanchard ◽  
Lisa Chang ◽  
Amir H. Rezvani ◽  
Stanley I. Rapoport ◽  
Ameer Y. Taha
Keyword(s):  
Arachidonic Acid ◽  
Rat Model ◽  
Acid Incorporation ◽  
Sensitive Line ◽  
Flinders Sensitive Line

Sirtuins and Neuropeptide y downregulation in Flinders Sensitive Line Rat Model of Depression

2021 ◽  
pp. 1-19
Author(s):  
Miranda Stiernborg ◽  
Paschalis Efstathopoulos ◽  
Andreas Lennartsson ◽  
Catharina Lavebratt ◽  
Aleksander A. Mathé
Keyword(s):  
Rat Model ◽  
Histone Deacetylases ◽  
Sirtuin 1 ◽  
Model Organisms ◽  
Age Related ◽  
Age Dependent ◽  
Sensitive Line ◽  
And Control ◽  
Temporal Trajectory ◽  
Flinders Sensitive Line

Abstract Objective: Since the NAD+-dependent histone deacetylases sirtuin-1 (SIRT1) and sirtuin-2 (SIRT2) are critically involved in epigenetics, endocrinology and immunology and affect the longevity in model organisms, we investigated their expression in brains of 3 month old and 14-15 month old rat model of depression Flinders Sensitive Line (FSL) and control Flinders Resistant Line (FRL) rats. In view of the dysregulated NPY system in depression we also studied NPY in young and old FSL to explore the temporal trajectory of depressive-like-ageing interaction. Methods: Sirt1, Sirt2 and Npy mRNA were determined using qRT-PCR in prefrontal cortex (PFC) from young and old FSL and FRL, and in hippocampi from young FSL and FRL. Results: PFC. Sirt1 expression was decreased in FSL (p=0.001). An interaction between age and genotype was found (p=0.032); young FSL had lower Sirt1 with respect to both age (p=0.026) and genotype (p=0.001). Sirt2 was lower in FSL (p=0.003). Npy mRNA was downregulated in FSL (p=0.001) but did not differ between the young and old rat groups. Hippocampus.Sirt1 was reduced in young FSL compared to young FRL (p=0.005). There was no difference in Sirt2 between FSL and FRL. Npy levels were decreased in hippocampus of young FSL compared to young FRL (p=0.003). Effects of ageing could not be investigated due to loss of samples. Conclusions: i. This is the first demonstration that SIRT1 and SIRT2 are changed in brain of FSL, a rat model of depression ; ii. The changes are age dependent; iii. Sirtuins are potential targets for treatment of age-related neurodegenerative diseases.

scholarly journals Altered fecal microbiota composition in the Flinders sensitive line rat model of depression

2018 ◽  
Vol 236 (5) ◽  
pp. 1445-1457 ◽  
Author(s):  
Sandra Tillmann ◽  
Anders Abildgaard ◽  
Gudrun Winther ◽  
Gregers Wegener
Keyword(s):  
Rat Model ◽  
Fecal Microbiota ◽  
Microbiota Composition ◽  
Sensitive Line ◽  
Flinders Sensitive Line

scholarly journals Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat

2019 ◽  
Vol 31 (04) ◽  
pp. 213-219 ◽  
Author(s):  
Oskar Jefsen ◽  
Kristoffer Højgaard ◽  
Sofie Laage Christiansen ◽  
Betina Elfving ◽  
David John Nutt ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Rat Model ◽  
Serotonin Receptor ◽  
Therapeutic Potential ◽  
Forced Swim Test ◽  
Psychiatric Illnesses ◽  
Immobility Time ◽  
Sensitive Line ◽  
Behavioural Tests ◽  
Flinders Sensitive Line

AbstractObjective:Psilocybin is a serotonin receptor agonist with a therapeutic potential for treatment-resistant depression and other psychiatric illnesses. We investigated whether the administration of psilocybin had an antidepressant-like effect in a rat model of depression.Methods:Using the Flinders Sensitive Line (FSL) rat model of depression, we assessed the antidepressant-like effect of psilocin and psilocybin, measured as a reduction in immobility time in the forced swim test (FST). We measured locomotor activity in an open field test (OFT) to control for stimulant properties of the drugs. We performed a set of experiments to test different doses, treatment paradigms, and timing of the tests in relation to the drug administration.Results:Psilocin and psilocybin showed no effect on immobility, struggling, or swimming behaviour in the FST and no effect on locomotor activity in the OFT. FSL rats did show significantly more immobility than their control strain, the Flinders Resistant Line, as expected.Conclusion:Psilocin and psilocybin showed no antidepressant-like effect in the FSL rats, despite a positive effect in humans. This suggests that other animal models of depression and other behavioural tests may be more appropriate for translational studies in the effects of psilocybin.

Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression

2016 ◽  
Vol 29 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Xi-Cong Liu ◽  
Sophie Erhardt ◽  
Michel Goiny ◽  
Göran Engberg ◽  
Aleksander A. Mathé
Keyword(s):  
Prefrontal Cortex ◽  
Rat Model ◽  
High Performance ◽  
Kynurenic Acid ◽  
Kynurenine Pathway ◽  
Genetic Animal Model ◽  
Animal Model Of Depression ◽  
Tryptophan Metabolites ◽  
Sensitive Line

ObjectiveThere is a growing interest in the role of kynurenine pathway and tryptophan metabolites in the pathophysiology of depression. In the present study, the metabolism of tryptophan along the kynurenine pathway was analysed in a rat model of depression.MethodsKynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK) were measured by high-performance liquid chromatography (HPLC) in prefrontal cortex (PFC) and frontal cortex (FC) in a rat model of depression, the Flinders Sensitive Line (FSL) and their controls, the Flinders Resistant Line (FRL) rats. In addition, KYNA was also measured in hippocampus, striatum and cerebellum.ResultsKYNA levels were reduced in the PFC of FSL rats compared with FRL rats, but did not differ with regard to the FC, hippocampus, striatum or cerebellum. 3-HK levels in PFC and FC, representing the activity of the microglial branch of the kynurenine pathway, did not differ between the FSL and FRL strains.ConclusionOur results suggest an imbalanced metabolism of the kynurenine pathway in the PFC of FSL rats.

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