scholarly journals Long-Evans Rats Acquire Operant Self-Administration of 20% Ethanol Without Sucrose Fading

2010 ◽  
Vol 35 (7) ◽  
pp. 1453-1463 ◽  
Author(s):  
Jeffrey A Simms ◽  
Jade J Bito-Onon ◽  
Susmita Chatterjee ◽  
Selena E Bartlett
Keyword(s):  
Self Administration ◽  
Long Evans

The effects of cannabidiol (CBD) on Δ⁹-tetrahydrocannabinol (THC) self-administration in male and female Long-Evans rats.

2017 ◽  
Vol 25 (4) ◽  
pp. 242-248 ◽  
Author(s):  
Alison G. P. Wakeford ◽  
Bradley B. Wetzell ◽  
Rebecca L. Pomfrey ◽  
Matthew M. Clasen ◽  
William W. Taylor ◽  
...  
Keyword(s):  
Self Administration ◽  
Male And Female ◽  
Long Evans

scholarly journals Increased alcohol self-administration following exposure to the predator odor TMT in high stress-reactive female rats

2020 ◽  
Author(s):  
Laura C. Ornelas ◽  
Ryan E. Tyler ◽  
Preethi Irukulapati ◽  
Sudheesha Paladugu ◽  
Joyce Besheer
Keyword(s):  
Individual Differences ◽  
Alcohol Drinking ◽  
Stress Reactivity ◽  
High Stress ◽  
Predator Odor ◽  
Female Rats ◽  
List Type ◽  
Self Administration ◽  
Male And Female ◽  
Long Evans

AbstractPost-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid. Additionally, individual differences in response to stress suggest resilient and susceptible populations. The current study exposed male and female Long Evans rats to the synthetically produced predator odor 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) to examine individual differences in stress-reactive behaviors (digging and immobility) and whether these differences could predict lasting consequences of TMT and increases in alcohol drinking. Male and female Long Evans rats were trained on operant alcohol self-administration. After 9 sessions, rats underwent exposure to TMT or water (Control) in a distinct context. 6 days after TMT exposure, rats underwent re-exposure to the TMT-paired context (without TMT), and a series of behavioral assessments (acoustic startle, zero maze, light/dark box), after which rats resumed alcohol self-administration. Rats were divided into two TMT-subgroups using a ratio of digging and immobility behavior during TMT exposure: TMT-subgroup 1 (low digging/immobility ratio) and TMT-subgroup 2 (high digging/immobility ratio). Digging/immobility ratio scores predicted elevated corticosterone levels during TMT exposure and reactivity during context re-exposure in males and females (TMT-subgroup 2), as well as elevated corticosterone levels after context re-exposure and hyperarousal behavior in females (TMT-subgroup 1). Furthermore, TMT stress reactivity predicted increases in alcohol self-administration, specifically in females. These data show that stress-reactivity can predict lasting behavioral changes which may lead to a better understanding of increases in alcohol drinking following stress in females and that individual differences in stress-reactive behaviors using TMT may be helpful to understand resilience/susceptibility to the lasting consequences of stress.HighlightsExposure to the predator odor TMT produces distinct behavioral phenotypes in male and female ratsMale and female high stress reactive rats show enhanced reactivity to the TMT-paired contextStress-reactivity during TMT predicts increases in alcohol self-administration, in femalesStress-reactivity may help to understand resilience/susceptibility and impact on alcohol drinking

scholarly journals Sex differences in alcohol self-administration and relapse-like behavior in Long-Evans rats

2017 ◽  
Vol 156 ◽  
pp. 1-9 ◽  
Author(s):  
Patrick A. Randall ◽  
Robert T. Stewart ◽  
Joyce Besheer
Keyword(s):  
Sex Differences ◽  
Self Administration ◽  
Long Evans
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