scholarly journals Sex differences in alcohol self-administration and relapse-like behavior in Long-Evans rats

2017 ◽  
Vol 156 ◽  
pp. 1-9 ◽  
Author(s):  
Patrick A. Randall ◽  
Robert T. Stewart ◽  
Joyce Besheer
Keyword(s):  
Sex Differences ◽  
Self Administration ◽  
Long Evans

scholarly journals Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking

2019 ◽  
Vol 22 (11) ◽  
pp. 710-723 ◽  
Author(s):  
Atul P Daiwile ◽  
Subramaniam Jayanthi ◽  
Bruce Ladenheim ◽  
Michael T McCoy ◽  
Christie Brannock ◽  
...  
Keyword(s):  
Sex Differences ◽  
Nucleus Accumbens ◽  
Fixed Ratio ◽  
Female Rats ◽  
Male Rats ◽  
Mrna Levels ◽  
Self Administration ◽  
Male And Female ◽  
Orexin Receptors ◽  
Male And Female Rats

Abstract Background Methamphetamine (METH) use disorder is prevalent worldwide. There are reports of sex differences in quantities of drug used and relapses to drug use among individuals with METH use disorder. However, the molecular neurobiology of these potential sex differences remains unknown. Methods We trained rats to self-administer METH (0. 1 mg/kg/infusion, i.v.) on an fixed-ratio-1 schedule for 20 days using two 3-hour daily METH sessions separated by 30-minute breaks. At the end of self-administration training, rats underwent tests of cue-induced METH seeking on withdrawal days 3 and 30. Twenty-four hours later, nucleus accumbens was dissected and then used to measure neuropeptide mRNA levels. Results Behavioral results show that male rats increased the number of METH infusions earlier during self-administration training and took more METH than females. Both male and female rats could be further divided into 2 phenotypes labeled high and low takers based on the degree of escalation that they exhibited during the course of the METH self-administration experiment. Both males and females exhibited incubation of METH seeking after 30 days of forced withdrawal. Females had higher basal mRNA levels of dynorphin and hypocretin/orexin receptors than males, whereas males expressed higher vasopressin mRNA levels than females under saline and METH conditions. Unexpectedly, only males showed increased expression of nucleus accumbens dynorphin after METH self-administration. Moreover, there were significant correlations between nucleus accumbens Hcrtr1, Hcrtr2, Crhr2, and Avpr1b mRNA levels and cue-induced METH seeking only in female rats. Conclusion Our results identify some behavioral and molecular differences between male and female rats that had self-administered METH. Sexual dimorphism in responses to METH exposure should be considered when developing potential therapeutic agents against METH use disorder.

Sex differences in the escalation of oral phencyclidine (PCP) self-administration under FR and PR schedules in rhesus monkeys

2005 ◽  
Vol 180 (3) ◽  
pp. 414-426 ◽  
Author(s):  
Marilyn E. Carroll ◽  
David K. Batulis ◽  
Kerry L. Landry ◽  
Andrew D. Morgan
Keyword(s):  
Sex Differences ◽  
Rhesus Monkeys ◽  
Self Administration

Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences

2002 ◽  
Vol 161 (3) ◽  
pp. 304-313 ◽  
Author(s):  
Marilyn Carroll ◽  
Andrew Morgan ◽  
Wendy Lynch ◽  
Una Campbell ◽  
Nancy Dess
Keyword(s):  
Sex Differences ◽  
Self Administration ◽  
Saccharin Intake ◽  
Intravenous Cocaine

scholarly journals Supplementation with Combined Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 Across Development Reveals Sex Differences in Physiological and Behavioural Effects of Western Diet in Long–Evans Rats

2020 ◽  
Vol 8 (10) ◽  
pp. 1527
Author(s):  
Elizabeth M. Myles ◽  
M. Elizabeth O’Leary ◽  
Rylan Smith ◽  
Chad W. MacPherson ◽  
Alexandra Oprea ◽  
...  
Keyword(s):  
Sex Differences ◽  
Early Life ◽  
Bifidobacterium Longum ◽  
Western Diet ◽  
Lactobacillus Helveticus ◽  
Calorie Intake ◽  
Dependent Manner ◽  
Probiotic Treatment ◽  
Long Evans ◽  
Diet Exposure

The gut microbiome affects various physiological and psychological processes in animals and humans, and environmental influences profoundly impact its composition. Disorders such as anxiety, obesity, and inflammation have been associated with certain microbiome compositions, which may be modulated in early life. In 62 Long–Evans rats, we characterised the effects of lifelong Bifidobacterium longum R0175 and Lactobacillus helveticus R0052 administration—along with Western diet exposure—on later anxiety, metabolic consequences, and inflammation. We found that the probiotic formulation altered specific anxiety-like behaviours in adulthood. We further show distinct sex differences in metabolic measures. In females, probiotic treatment increased calorie intake and leptin levels without affecting body weight. In males, the probiotic seemed to mitigate the effects of Western diet on adult weight gain and calorie intake, without altering leptin levels. The greatest inflammatory response was seen in male, Western-diet-exposed, and probiotic-treated rats, which may be related to levels of specific steroid hormones in these groups. These results suggest that early-life probiotic supplementation and diet exposure can have particular implications on adult health in a sex-dependent manner, and highlight the need for further studies to examine the health outcomes of probiotic treatment in both sexes.

scholarly journals Sex differences in the effect of the FKBP5 inhibitor SAFit2 on anxiety and stress-induced reinstatement following cocaine self-administration

2020 ◽  
Vol 13 ◽  
pp. 100232
Author(s):  
Krista L. Connelly ◽  
Cassandra C. Wolsh ◽  
Jeffrey L. Barr ◽  
Michael Bauder ◽  
Felix Hausch ◽  
...  
Keyword(s):  
Sex Differences ◽  
Self Administration

Reinstatement of cocaine self-administration in rats: sex differences

2000 ◽  
Vol 148 (2) ◽  
pp. 196-200 ◽  
Author(s):  
Wendy J. Lynch ◽  
Marilyn E. Carroll
Keyword(s):  
Sex Differences ◽  
Self Administration
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