scholarly journals Low Doses of 17α-Estradiol and 17β-Estradiol Facilitate, Whereas Higher Doses of Estrone and 17α- and 17β-Estradiol Impair, Contextual Fear Conditioning in Adult Female Rats

2009 ◽  
Vol 35 (2) ◽  
pp. 547-559 ◽  
Author(s):  
Cindy K Barha ◽  
Gemma L Dalton ◽  
Liisa AM Galea
Keyword(s):  
Fear Conditioning ◽  
Adult Female ◽  
Contextual Fear Conditioning ◽  
Female Rats ◽  
Low Doses ◽  
Contextual Fear ◽  
17Β Estradiol ◽  
Higher Doses

scholarly journals Behavioral Expression of Contextual Fear in Male and Female Rats

2021 ◽  
Vol 15 ◽  
Author(s):  
Amanda S. Russo ◽  
Ryan G. Parsons
Keyword(s):  
Fear Conditioning ◽  
Freezing Behavior ◽  
Contextual Fear Conditioning ◽  
Female Rats ◽  
Post Traumatic Stress ◽  
Male And Female ◽  
Contextual Fear ◽  
Male And Female Rats ◽  
Fear Potentiated Startle ◽  
Fear And Anxiety

The study of fear conditioning has led to a better understanding of fear and anxiety-based disorders such as post-traumatic stress disorder (PTSD). Despite the fact many of these disorders are more common in women than in men, the vast majority of work investigating fear conditioning in rodents has been conducted in males. The goal of the work presented here was to better understand how biological sex affects contextual fear conditioning and expression. To this end, rats of both sexes were trained to fear a specific context and fear responses were measured upon re-exposure to the conditioning context. In the first experiment, male and female rats were given context fear conditioning and tested the next day during which freezing behavior was measured. In the second experiment, rats were trained and tested in a similar fashion while fear-potentiated startle and defecation were measured. We found that males showed more freezing behavior than females during a fear expression test. The expression of fear-potentiated startle did not differ between sexes, while males exhibited more defecation during a test in a novel context. These data suggest that the expression of defensive behavior differs between sexes and highlight the importance of using multiple measures of fear when comparing between sexes.

scholarly journals Stress before Puberty Exerts a Sex- and Age-Related Impact on Auditory and Contextual Fear Conditioning in the Rat

2007 ◽  
Vol 2007 ◽  
pp. 1-12 ◽  
Author(s):  
Maria Toledo-Rodriguez ◽  
Carmen Sandi
Keyword(s):  
Fear Conditioning ◽  
Conditioned Fear ◽  
Early Adulthood ◽  
Contextual Fear Conditioning ◽  
Female Rats ◽  
Adult Males ◽  
Contextual Fear ◽  
Male And Female Rats ◽  
Age Related ◽  
The Impact

Adolescence is a period of major physical, hormonal, and psychological changes. It is also characterized by a significant increase in the incidence of psychopathologies and this increase is gender-specific. Stress during adolescence is associated with the development of psychiatric disorders later in life. In this study, we evaluated the impact of psychogenic stress (exposure to predator odor followed by placement on an elevated platform) experienced before puberty (days 28–30) on fear memories and hormonal response of male and female rats during adolescence and early adulthood. Stress before puberty impacted in a sex- and age-specific way on the responses to auditory and contextual fear conditioning in adolescence and adulthood: (a) increased conditioned fear to the tone in males during adolescence but not during adulthood; (b) impaired extinction to the tone in adult males; and (c) reduced freezing responses to the context in adolescent females. Stress before puberty did not influence the corticosterone levels 30 minutes after an additional stressor given in adulthood. These results indicate that stress experienced prior to puberty can exert a sex-related differential impact on fear-related behaviors displayed by individuals during late adolescence and early adulthood.

Role of dorsal and ventral hippocampal muscarinic receptor activity in acquisition and retention of contextual fear conditioning.

2020 ◽  
Vol 134 (5) ◽  
pp. 460-470
Author(s):  
Claudia C. Pinizzotto ◽  
Nicholas A. Heroux ◽  
Colin J. Horgan ◽  
Mark E. Stanton
Keyword(s):  
Fear Conditioning ◽  
Muscarinic Receptor ◽  
Contextual Fear Conditioning ◽  
Receptor Activity ◽  
Contextual Fear

scholarly journals Dysbindin-1 loss compromises NMDAR-dependent synaptic plasticity and contextual fear conditioning

Hippocampus ◽  
2013 ◽  
Vol 24 (2) ◽  
pp. 204-213 ◽  
Author(s):  
W. Bailey Glen ◽  
Bryant Horowitz ◽  
Gregory C. Carlson ◽  
Tyrone D. Cannon ◽  
Konrad Talbot ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Contextual Fear

Hippocampal NMDA receptor blockade impairs CREB phosphorylation in amygdala after contextual fear conditioning

Hippocampus ◽  
2013 ◽  
Vol 23 (7) ◽  
pp. 545-551 ◽  
Author(s):  
Cesar Augusto de Oliveira Coelho ◽  
Tatiana Lima Ferreira ◽  
Juliana Carlota Kramer Soares ◽  
Maria Gabriela Menezes Oliveira
Keyword(s):  
Nmda Receptor ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Receptor Blockade ◽  
Creb Phosphorylation ◽  
Contextual Fear ◽  
Nmda Receptor Blockade

scholarly journals Hippocampal but not amygdalar volume affects contextual fear conditioning in humans

2011 ◽  
Vol 33 (2) ◽  
pp. 478-488 ◽  
Author(s):  
Sebastian T. Pohlack ◽  
Frauke Nees ◽  
Claudia Liebscher ◽  
Raffaele Cacciaglia ◽  
Slawomira J. Diener ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Contextual Fear ◽  
Amygdalar Volume
Sign in / Sign up

Export Citation Format

Share Document