scholarly journals Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

2008 ◽  
Vol 11 (4) ◽  
pp. 476-487 ◽  
Author(s):  
Sofia Papadia ◽  
Francesc X Soriano ◽  
Frédéric Léveillé ◽  
Marc-Andre Martel ◽  
Kelly A Dakin ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Activity ◽  
Antioxidant Defenses

scholarly journals Excitotoxic Insults Lead to Peroxiredoxin Hyperoxidation

2009 ◽  
Vol 2 (2) ◽  
pp. 110-113 ◽  
Author(s):  
Frédéric Léveillé ◽  
Francesc X. Soriano ◽  
Sofia Papadia ◽  
Giles E. Hardingham
Keyword(s):  
Oxidative Stress ◽  
Nmda Receptor ◽  
Response Curve ◽  
Synaptic Activity ◽  
Receptor Activity ◽  
Antioxidant Defenses ◽  
Enzymatic System ◽  
System A ◽  
Highly Sensitive ◽  
Toxic Concentrations

Post-mitotic neurons must have strong antioxidant defenses to survive the lifespan of the organism. We recently showed that neuronal antioxidant defenses are boosted by synaptic activity. Elevated synaptic activity, acting via the N-methyl-D-aspartate (NMDA) receptor, enhances thioredoxin activity, facilitates the reduction of hyperoxidized peroxiredoxins, and promotes resistance to oxidative stress. In contrast, blockade of spontaneous synaptic NMDA receptor activity renders neurons highly sensitive to hyperoxidation of peroxiredoxins by oxidative insults. These NMDA receptor-dependent effects are mediated in part by a coordinated program of gene expression changes centered on the thioredoxin-peroxiredoxin system, a thiol-based enzymatic system which is an important reducer of oxidative stressors such as hydroperoxides. We show here that while too little glutamatergic activity can render neurons vulnerable to peroxiredoxin hyperoxidation, so can too much. Exposure of neurons to toxic concentrations of glutamate, activating both synaptic and extrasynaptic NMDA receptors, acutely induces peroxiredoxin hyperoxidation. Thus, the effect of NMDA receptor activity on the activity of neuronal peroxiredoxins follows the classical U-shaped dose response curve.

scholarly journals Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior

2007 ◽  
Vol 27 (13) ◽  
pp. 3593-3602 ◽  
Author(s):  
J. Wang ◽  
S. Carnicella ◽  
K. Phamluong ◽  
J. Jeanblanc ◽  
J. A. Ronesi ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Alcohol Drinking ◽  
Drinking Behavior ◽  
Dorsal Striatum ◽  
Receptor Activity ◽  
Long Term Facilitation

scholarly journals Mechanism of differential control of NMDA receptor activity by NR2 subunits

Nature ◽  
2009 ◽  
Vol 459 (7247) ◽  
pp. 703-707 ◽  
Author(s):  
Marc Gielen ◽  
Beth Siegler Retchless ◽  
Laetitia Mony ◽  
Jon W. Johnson ◽  
Pierre Paoletti
Keyword(s):  
Nmda Receptor ◽  
Receptor Activity ◽  
Differential Control ◽  
Nr2 Subunits

Neither peripheral nerve input nor cortical NMDA receptor activity are necessary for recovery of a disrupted barrel pattern in rat somatosensory cortex

2001 ◽  
Vol 129 (1) ◽  
pp. 95-106 ◽  
Author(s):  
Carolyn B Boylan ◽  
Kay L Kesterson ◽  
Carol A Bennett-Clarke ◽  
Nicolas L Chiaia ◽  
Robert W Rhoades
Keyword(s):  
Nmda Receptor ◽  
Peripheral Nerve ◽  
Somatosensory Cortex ◽  
Receptor Activity ◽  
Rat Somatosensory Cortex

scholarly journals Erratum: Corrigendum: Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Paul S. Baxter ◽  
Karen F. S. Bell ◽  
Philip Hasel ◽  
Angela M. Kaindl ◽  
Michael Fricker ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Transcriptional Control ◽  
Receptor Activity ◽  
Glutathione System
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