scholarly journals Erratum: Corrigendum: Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Paul S. Baxter ◽  
Karen F. S. Bell ◽  
Philip Hasel ◽  
Angela M. Kaindl ◽  
Michael Fricker ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Transcriptional Control ◽  
Receptor Activity ◽  
Glutathione System

scholarly journals Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Paul S. Baxter ◽  
Karen F.S. Bell ◽  
Philip Hasel ◽  
Angela M. Kaindl ◽  
Michael Fricker ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Transcriptional Control ◽  
Redox Balance ◽  
Synaptic Activity ◽  
Antioxidant Defenses ◽  
Glutathione System ◽  
Active Neuron ◽  
Glutathione Biosynthesis ◽  
The Face ◽  
Dependent Cell

Abstract How the brain’s antioxidant defenses adapt to changing demand is incompletely understood. Here we show that synaptic activity is coupled, via the NMDA receptor (NMDAR), to control of the glutathione antioxidant system. This tunes antioxidant capacity to reflect the elevated needs of an active neuron, guards against future increased demand and maintains redox balance in the brain. This control is mediated via a programme of gene expression changes that boosts the synthesis, recycling and utilization of glutathione, facilitating ROS detoxification and preventing Puma-dependent neuronal apoptosis. Of particular importance to the developing brain is the direct NMDAR-dependent transcriptional control of glutathione biosynthesis, disruption of which can lead to degeneration. Notably, these activity-dependent cell-autonomous mechanisms were found to cooperate with non-cell-autonomous Nrf2-driven support from astrocytes to maintain neuronal GSH levels in the face of oxidative insults. Thus, developmental NMDAR hypofunction and glutathione system deficits, separately implicated in several neurodevelopmental disorders, are mechanistically linked.

scholarly journals Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior

2007 ◽  
Vol 27 (13) ◽  
pp. 3593-3602 ◽  
Author(s):  
J. Wang ◽  
S. Carnicella ◽  
K. Phamluong ◽  
J. Jeanblanc ◽  
J. A. Ronesi ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Alcohol Drinking ◽  
Drinking Behavior ◽  
Dorsal Striatum ◽  
Receptor Activity ◽  
Long Term Facilitation

scholarly journals Mechanism of differential control of NMDA receptor activity by NR2 subunits

Nature ◽  
2009 ◽  
Vol 459 (7247) ◽  
pp. 703-707 ◽  
Author(s):  
Marc Gielen ◽  
Beth Siegler Retchless ◽  
Laetitia Mony ◽  
Jon W. Johnson ◽  
Pierre Paoletti
Keyword(s):  
Nmda Receptor ◽  
Receptor Activity ◽  
Differential Control ◽  
Nr2 Subunits

Neither peripheral nerve input nor cortical NMDA receptor activity are necessary for recovery of a disrupted barrel pattern in rat somatosensory cortex

2001 ◽  
Vol 129 (1) ◽  
pp. 95-106 ◽  
Author(s):  
Carolyn B Boylan ◽  
Kay L Kesterson ◽  
Carol A Bennett-Clarke ◽  
Nicolas L Chiaia ◽  
Robert W Rhoades
Keyword(s):  
Nmda Receptor ◽  
Peripheral Nerve ◽  
Somatosensory Cortex ◽  
Receptor Activity ◽  
Rat Somatosensory Cortex
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