Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression

2006 ◽  
Vol 9 (5) ◽  
pp. 636-641 ◽  
Author(s):  
Camilla Bellone ◽  
Christian Lüscher
Keyword(s):  
Ampa Receptor ◽  
Long Term Depression

scholarly journals Targeted In Vivo Mutations of the AMPA Receptor Subunit GluR2 and Its Interacting Protein PICK1 Eliminate Cerebellar Long-Term Depression

Neuron ◽  
2006 ◽  
Vol 49 (6) ◽  
pp. 845-860 ◽  
Author(s):  
Jordan P. Steinberg ◽  
Kogo Takamiya ◽  
Ying Shen ◽  
Jun Xia ◽  
Maria E. Rubio ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Receptor Subunit ◽  
Long Term Depression ◽  
Interacting Protein ◽  
Ampa Receptor Subunit

Long-term depression in the sensorimotor cortex induced by repeated delivery of 10 Hz trains in vivo

Neuroscience ◽  
2006 ◽  
Vol 140 (1) ◽  
pp. 13-20 ◽  
Author(s):  
C.M. Werk ◽  
H.S. Klein ◽  
C.E. Nesbitt ◽  
C.A. Chapman
Keyword(s):  
Sensorimotor Cortex ◽  
Long Term Depression

Long-term depression of excitatory transmission in the lateral septum

2021 ◽  
Author(s):  
Chanchanok Chaichim ◽  
Madeleine Jessica Radnan ◽  
Gadiel Dumlao ◽  
John M. Power
Keyword(s):  
Sex Differences ◽  
Drugs Of Abuse ◽  
Brain Slices ◽  
Lateral Septum ◽  
Network Activity ◽  
Excitatory Postsynaptic Potential ◽  
Glutamatergic Transmission ◽  
Long Term Depression

Neurons in the lateral septum (LS) integrate glutamatergic synaptic inputs, primarily from hippocampus, and send inhibitory projections to brain regions involved in reward and the generation of motivated behavior. Motivated learning and drugs of abuse have been shown to induce long-term changes in the strength of glutamatergic synapses in the LS, but the cellular mechanisms underlying long-term synaptic modification in the LS are poorly understood. Here we examined synaptic transmission and long-term depression (LTD) in brain slices prepared from male and female C57BL/6 mice. No sex differences were observed in whole-cell patch-clamp recordings of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) and N-methyl-D-aspartate receptor (NMDA-R) mediated currents. Low frequency stimulation of the fimbria fibre bundle (1 Hz 15 min) induced LTD of the LS field excitatory postsynaptic potential (fEPSP). Induction of LTD was blocked by the NMDA-R antagonist APV, but not the selective antagonist of GluN2B-containing NMDA-R ifenprodil. These results demonstrate the NMDA-R dependence of LTD in the LS. The LS is a sexually dimorphic structure and sex differences in glutamatergic transmission have been reported in vivo; our results suggest sex differences observed in vivo result from network activity rather than intrinsic differences in glutamatergic transmission.

Stimulation at 1-5 Hz does not produce long-term depression or depotentiation in the hippocampus of the adult rat in vivo

1995 ◽  
Vol 74 (4) ◽  
pp. 1793-1799 ◽  
Author(s):  
M. L. Errington ◽  
T. V. Bliss ◽  
G. Richter-Levin ◽  
K. Yenk ◽  
V. Doyere ◽  
...  
Keyword(s):  
Young Animal ◽  
Low Frequency ◽  
Long Term Depression ◽  
Developmentally Regulated ◽  
Adult Rats ◽  
Adult Rat ◽  
Area Ca1 ◽  
Awake Rat

1. We examined the efficacy of low-frequency trains (1-5 Hz) in producing long-term depression (LTD) or depotentiation in the hippocampus of the awake adult rat and in anesthetized rats aged from 10 days to 3 mo. 2. In the dentate gyrus we found no evidence that low-frequency trains produce either depotentiation or LTD in the awake, adult animal or in the anesthetized animal at any age tested (10 days-adult). 3. In area CA1 of both awake and anesthetized adult rats, we also found no evidence that low-frequency trains induced either LTD or depotentiation. Only in area CA1 of very young rats (10-11 days) was clear evidence for LTD and depotentiation obtained; at this age experiments were only possible in anesthetized animals. By 16 days, the ability to display both LTD and depotentiation was lost. 4. These experiments suggest that repetitive low-frequency stimulation evokes a developmentally regulated form of activity-dependent depression that in the hippocampus is limited to specific pathways in the young animal. Our results leave open the question of whether alternative patterns of activity can induce LTD and/or depotentiation in the adult awake rat.

scholarly journals Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo

2020 ◽  
Vol 13 ◽  
Author(s):  
Michael Popiolek ◽  
Yukitoshi Izumi ◽  
Allen T. Hopper ◽  
Jing Dai ◽  
Silke Miller ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Hippocampal Slices ◽  
Long Term Depression
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