scholarly journals Targeted In Vivo Mutations of the AMPA Receptor Subunit GluR2 and Its Interacting Protein PICK1 Eliminate Cerebellar Long-Term Depression

Neuron ◽  
2006 ◽  
Vol 49 (6) ◽  
pp. 845-860 ◽  
Author(s):  
Jordan P. Steinberg ◽  
Kogo Takamiya ◽  
Ying Shen ◽  
Jun Xia ◽  
Maria E. Rubio ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Receptor Subunit ◽  
Long Term Depression ◽  
Interacting Protein ◽  
Ampa Receptor Subunit

scholarly journals Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Javier Díaz-Alonso ◽  
Wade Morishita ◽  
Salvatore Incontro ◽  
Jeffrey Simms ◽  
Julia Holtzman ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Morris Water Maze ◽  
Ampa Receptor ◽  
Water Maze ◽  
Long Term Potentiation ◽  
Receptor Subunit ◽  
Terminal Domain ◽  
Term Potentiation ◽  
Ampa Receptor Subunit

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.

scholarly journals A Juvenile form of Postsynaptic Hippocampal Long‐Term Potentiation in Mice Deficient for the AMPA Receptor Subunit GluR‐A

2003 ◽  
Vol 553 (3) ◽  
pp. 843-856 ◽  
Author(s):  
Vidar Jensen ◽  
Katharina M. M. Kaiser ◽  
Thilo Borchardt ◽  
Giselind Adelmann ◽  
Andrei Rozov ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Long Term Potentiation ◽  
Receptor Subunit ◽  
Juvenile Form ◽  
Term Potentiation ◽  
Ampa Receptor Subunit

scholarly journals Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity

2020 ◽  
Vol 117 (9) ◽  
pp. 4948-4958 ◽  
Author(s):  
Adeline J. H. Yong ◽  
Han L. Tan ◽  
Qianwen Zhu ◽  
Alexei M. Bygrave ◽  
Richard C. Johnson ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Phosphorylation Site ◽  
Long Term Potentiation ◽  
Interacting Protein ◽  
Hebbian Plasticity ◽  
Term Potentiation ◽  
Ampa Receptor Subunit

Hebbian plasticity, comprised of long-term potentiation (LTP) and depression (LTD), allows neurons to encode and respond to specific stimuli; while homeostatic synaptic scaling is a counterbalancing mechanism that enables the maintenance of stable neural circuits. Both types of synaptic plasticity involve the control of postsynaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPAR) abundance, which is modulated by AMPAR phosphorylation. To address the necessity of GluA2 phospho-Y876 in synaptic plasticity, we generated phospho-deficient GluA2 Y876F knock-in mice. We show that, while GluA2 phospho-Y876 is not necessary for Hebbian plasticity, it is essential for both in vivo and in vitro homeostatic upscaling. Bidirectional changes in GluA2 phospho-Y876 were observed during homeostatic scaling, with a decrease during downscaling and an increase during upscaling. GluA2 phospho-Y876 is necessary for synaptic accumulation of glutamate receptor interacting protein 1 (GRIP1), a crucial scaffold protein that delivers AMPARs to synapses, during upscaling. Furthermore, increased phosphorylation at GluA2 Y876 increases GluA2 binding to GRIP1. These results demonstrate that AMPAR trafficking during homeostatic upscaling can be gated by a single phosphorylation site on the GluA2 subunit.

Sexually dimorphic long-term effects of an early life experience on AMPA receptor subunit expression in rat brain

Neuroscience ◽  
2014 ◽  
Vol 257 ◽  
pp. 49-64 ◽  
Author(s):  
S. Katsouli ◽  
A. Stamatakis ◽  
P. Giompres ◽  
E.D. Kouvelas ◽  
F. Stylianopoulou ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Early Life ◽  
Life Experience ◽  
Sexually Dimorphic ◽  
Receptor Subunit ◽  
Long Term Effects ◽  
Early Life Experience ◽  
Ampa Receptor Subunit ◽  
Subunit Expression

scholarly journals Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model

2009 ◽  
Vol 16 (6) ◽  
pp. 379-386 ◽  
Author(s):  
D. J. Sanderson ◽  
M. A. Good ◽  
K. Skelton ◽  
R. Sprengel ◽  
P. H. Seeburg ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Ampa Receptor ◽  
Knockout Mice ◽  
Dual Process ◽  
Memory Model ◽  
Receptor Subunit ◽  
Short Term ◽  
Process Memory ◽  
Ampa Receptor Subunit

scholarly journals Author response: Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

2020 ◽  
Author(s):  
Javier Díaz-Alonso ◽  
Wade Morishita ◽  
Salvatore Incontro ◽  
Jeffrey Simms ◽  
Julia Holtzman ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Long Term Potentiation ◽  
Author Response ◽  
Receptor Subunit ◽  
Term Potentiation ◽  
Ampa Receptor Subunit
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