scholarly journals SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity

2012 ◽  
Vol 15 (6) ◽  
pp. 845-852 ◽  
Author(s):  
Sophie E L Chamberlain ◽  
Inmaculada M González-González ◽  
Kevin A Wilkinson ◽  
Filip A Konopacki ◽  
Sriharsha Kantamneni ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Receptor Trafficking ◽  
Kainate Receptor

Synaptic plasticity of kainate receptors

2006 ◽  
Vol 34 (5) ◽  
pp. 949-951 ◽  
Author(s):  
J.R. Mellor
Keyword(s):  
Synaptic Plasticity ◽  
Receptor Trafficking ◽  
Synaptic Activity ◽  
Kainate Receptors ◽  
Ionotropic Glutamate Receptors ◽  
Kainate Receptor ◽  
Ionotropic Glutamate Receptor ◽  
Cellular Mechanisms ◽  
The Third ◽  
Current State

Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors. The third subtype of ionotropic glutamate receptor, kainate receptors, has not been studied to the same extent, but recent evidence shows that these receptors also exhibit synaptic plasticity in response to activity. There is also a growing body of data on the mechanisms underlying kainate receptor trafficking and the proteins they interact with. This review summarizes the current state of knowledge on this topic, focusing on the evidence for the removal or insertion of functional kainate receptors in response to synaptic activity and the cellular mechanisms that underlie this regulation of neuronal kainate receptor function.

Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory

2010 ◽  
Vol 11 (10) ◽  
pp. 675-681 ◽  
Author(s):  
Harmen J. Krugers ◽  
Casper C. Hoogenraad ◽  
Laurent Groc
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Stress Hormones ◽  
Receptor Trafficking ◽  
Ampa Receptor Trafficking

scholarly journals A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity

2009 ◽  
Vol 9 (Suppl 1) ◽  
pp. S44 ◽  
Author(s):  
Yafelle Serulle ◽  
Ipe Ninan ◽  
Daniela Puzzo ◽  
Maria McCarthy ◽  
Latika Khatri ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Protein Kinase ◽  
Ampa Receptor ◽  
Receptor Trafficking ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Ampa Receptor Trafficking

Glutamate Receptor Trafficking in Synaptic Plasticity

2002 ◽  
Vol 2002 (156) ◽  
pp. re14-re14 ◽  
Author(s):  
A. Contractor ◽  
S. F. Heinemann
Keyword(s):  
Synaptic Plasticity ◽  
Glutamate Receptor ◽  
Receptor Trafficking ◽  
Glutamate Receptor Trafficking

Receptor Trafficking and the Regulation of Synaptic Plasticity by SUMO

2013 ◽  
Vol 15 (4) ◽  
pp. 692-706 ◽  
Author(s):  
Jia Luo ◽  
Emi Ashikaga ◽  
Philip P. Rubin ◽  
Michaela J. Heimann ◽  
Keri L. Hildick ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Receptor Trafficking

Early events in the trafficking of N-methyl-d-aspartate (NMDA) receptors

2003 ◽  
Vol 31 (4) ◽  
pp. 885-888 ◽  
Author(s):  
R.J. Wenthold ◽  
N. Sans ◽  
S. Standley ◽  
K. Prybylowski ◽  
R.S. Petralia
Keyword(s):  
Endoplasmic Reticulum ◽  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Nmda Receptors ◽  
Biosynthetic Pathway ◽  
Biological Properties ◽  
Receptor Trafficking ◽  
Excitatory Synapses ◽  
Multiple Functions ◽  
Subunit Assembly

The N-methyl-d-aspartate (NMDA) receptor plays a central role at excitatory synapses where it has been implicated in multiple functions associated with synaptic plasticity. While this receptor has been intensely studied with respect to its physiology and pharmacology, its cell-biological properties, such as subunit assembly, post-translational processing and trafficking in neurons, are only beginning to be addressed. Critical to many of the functions of the NMDA receptor are the multiple proteins with which it interacts. While these interactions have been most thoroughly studied with respect to the receptor at the synapse, the same proteins may also interact with the receptor much earlier in its biosynthetic pathway and play important roles in receptor trafficking from the endoplasmic reticulum to the synapse.

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