NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

2007 ◽  
Vol 8 (6) ◽  
pp. 1-1 ◽  
Author(s):  
C. Geoffrey Lau ◽  
R. Suzanne Zukin
Keyword(s):  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Neuropsychiatric Disorders ◽  
Receptor Trafficking

Early events in the trafficking of N-methyl-d-aspartate (NMDA) receptors

2003 ◽  
Vol 31 (4) ◽  
pp. 885-888 ◽  
Author(s):  
R.J. Wenthold ◽  
N. Sans ◽  
S. Standley ◽  
K. Prybylowski ◽  
R.S. Petralia
Keyword(s):  
Endoplasmic Reticulum ◽  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Nmda Receptors ◽  
Biosynthetic Pathway ◽  
Biological Properties ◽  
Receptor Trafficking ◽  
Excitatory Synapses ◽  
Multiple Functions ◽  
Subunit Assembly

The N-methyl-d-aspartate (NMDA) receptor plays a central role at excitatory synapses where it has been implicated in multiple functions associated with synaptic plasticity. While this receptor has been intensely studied with respect to its physiology and pharmacology, its cell-biological properties, such as subunit assembly, post-translational processing and trafficking in neurons, are only beginning to be addressed. Critical to many of the functions of the NMDA receptor are the multiple proteins with which it interacts. While these interactions have been most thoroughly studied with respect to the receptor at the synapse, the same proteins may also interact with the receptor much earlier in its biosynthetic pathway and play important roles in receptor trafficking from the endoplasmic reticulum to the synapse.

scholarly journals Imbalanced post- and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders

2021 ◽  
Author(s):  
Ahmed Eltokhi ◽  
Miguel A. Gonzalez-Lozano ◽  
Lars-Lennart Oettl ◽  
Andrey Rozov ◽  
Claudia Pitzer ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Social Interaction ◽  
Social Behavior ◽  
Ampa Receptors ◽  
Signal To Noise Ratio ◽  
Signal Transmission ◽  
Neuropsychiatric Disorders ◽  
Autism Spectrum ◽  
Strong Impact ◽  
Odor Processing

AbstractMutations in SHANK genes play an undisputed role in neuropsychiatric disorders. Until now, research has focused on the postsynaptic function of SHANKs, and prominent postsynaptic alterations in glutamatergic signal transmission have been reported in Shank KO mouse models. Recent studies have also suggested a possible presynaptic function of SHANK proteins, but these remain poorly defined. In this study, we examined how SHANK2 can mediate electrophysiological, molecular, and behavioral effects by conditionally overexpressing either wild-type SHANK2A or the extrasynaptic SHANK2A(R462X) variant. SHANK2A overexpression affected pre- and postsynaptic targets and revealed a reversible, development-dependent autism spectrum disorder-like behavior. SHANK2A also mediated redistribution of Ca2+-permeable AMPA receptors between apical and basal hippocampal CA1 dendrites, leading to impaired synaptic plasticity in the basal dendrites. Moreover, SHANK2A overexpression reduced social interaction and increased the excitatory noise in the olfactory cortex during odor processing. In contrast, overexpression of the extrasynaptic SHANK2A(R462X) variant did not impair hippocampal synaptic plasticity, but still altered the expression of presynaptic/axonal signaling proteins. We also observed an attention-deficit/hyperactivity-like behavior and improved social interaction along with enhanced signal-to-noise ratio in cortical odor processing. Our results suggest that the disruption of pre- and postsynaptic SHANK2 functions caused by SHANK2 mutations has a strong impact on social behavior. These findings indicate that pre- and postsynaptic SHANK2 actions cooperate for normal neuronal function, and that an imbalance between these functions may lead to different neuropsychiatric disorders.

Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory

2010 ◽  
Vol 11 (10) ◽  
pp. 675-681 ◽  
Author(s):  
Harmen J. Krugers ◽  
Casper C. Hoogenraad ◽  
Laurent Groc
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Stress Hormones ◽  
Receptor Trafficking ◽  
Ampa Receptor Trafficking

Targeted disruption to NMDA receptor dependent synaptic plasticity in area CA1 of the hippocampus

2021 ◽  
pp. 113808
Author(s):  
Alejandra Arias-Cavieres ◽  
Ateh Fonteh ◽  
Carolina I. Castro-Rivera ◽  
Alfredo J. Garcia
Keyword(s):  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Targeted Disruption ◽  
Area Ca1

scholarly journals Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation

Aging Cell ◽  
2012 ◽  
Vol 11 (2) ◽  
pp. 336-344 ◽  
Author(s):  
Coline Haxaire ◽  
Fabrice R Turpin ◽  
Brigitte Potier ◽  
Myriam Kervern ◽  
Pierre-Marie Sinet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Receptor Activation ◽  
Hippocampal Synaptic Plasticity ◽  
Age Related ◽  
Nmda Receptor Activation
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