Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain

2007 ◽  
Vol 4 (4) ◽  
pp. 331-336 ◽  
Author(s):  
Hans-Ulrich Dodt ◽  
Ulrich Leischner ◽  
Anja Schierloh ◽  
Nina Jährling ◽  
Christoph Peter Mauch ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Neuronal Networks ◽  
Three Dimensional

scholarly journals Comparative three-dimensional connectome map of motor cortical projections in the mouse brain

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Minju Jeong ◽  
Yongsoo Kim ◽  
Jeongjin Kim ◽  
Daniel D. Ferrante ◽  
Partha P. Mitra ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Three Dimensional ◽  
Cortical Projections ◽  
Motor Cortical

Three-dimensional inversion recovery manganese-enhanced MRI of mouse brain using super-resolution reconstruction to visualize nuclei involved in higher brain function

2014 ◽  
Vol 27 (7) ◽  
pp. 749-759 ◽  
Author(s):  
Dana S. Poole ◽  
Esben Plenge ◽  
Dirk H. J. Poot ◽  
Egbert A. J. F. Lakke ◽  
Wiro J. Niessen ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Brain Function ◽  
Three Dimensional ◽  
Super Resolution ◽  
Inversion Recovery ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry

2005 ◽  
Vol 16 (7) ◽  
pp. 1093-1099 ◽  
Author(s):  
Anna C. Crecelius ◽  
D. Shannon Cornett ◽  
Richard M. Caprioli ◽  
Betsy Williams ◽  
Benoit M. Dawant ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Protein Expression ◽  
Mouse Brain ◽  
Imaging Mass Spectrometry ◽  
Three Dimensional ◽  
Brain Structures

scholarly journals A Three-dimensional MRI Atlas of the Mouse Brain with Estimates of the Average and Variability

2004 ◽  
Vol 15 (5) ◽  
pp. 639-645 ◽  
Author(s):  
N. Kovačević ◽  
J.T. Henderson ◽  
E. Chan ◽  
N. Lifshitz ◽  
J. Bishop ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Three Dimensional

scholarly journals Neuroanatomical phenotyping of the mouse brain with three-dimensional autofluorescence imaging

2012 ◽  
Vol 44 (15) ◽  
pp. 778-785 ◽  
Author(s):  
Jacqueline A. Gleave ◽  
Michael D. Wong ◽  
Jun Dazai ◽  
Maliha Altaf ◽  
R. Mark Henkelman ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Mouse Brain ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Brain Structures ◽  
Small Scale ◽  
Specimen Preparation ◽  
Normal Brain ◽  
Autofluorescence Imaging ◽  
The Brain

The structural organization of the brain is important for normal brain function and is critical to understand in order to evaluate changes that occur during disease processes. Three-dimensional (3D) imaging of the mouse brain is necessary to appreciate the spatial context of structures within the brain. In addition, the small scale of many brain structures necessitates resolution at the ∼10 μm scale. 3D optical imaging techniques, such as optical projection tomography (OPT), have the ability to image intact large specimens (1 cm3) with ∼5 μm resolution. In this work we assessed the potential of autofluorescence optical imaging methods, and specifically OPT, for phenotyping the mouse brain. We found that both specimen size and fixation methods affected the quality of the OPT image. Based on these findings we developed a specimen preparation method to improve the images. Using this method we assessed the potential of optical imaging for phenotyping. Phenotypic differences between wild-type male and female mice were quantified using computer-automated methods. We found that optical imaging of the endogenous autofluorescence in the mouse brain allows for 3D characterization of neuroanatomy and detailed analysis of brain phenotypes. This will be a powerful tool for understanding mouse models of disease and development and is a technology that fits easily within the workflow of biology and neuroscience labs.

A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy

Neuroscience ◽  
2005 ◽  
Vol 135 (4) ◽  
pp. 1203-1215 ◽  
Author(s):  
Y. Ma ◽  
P.R. Hof ◽  
S.C. Grant ◽  
S.J. Blackband ◽  
R. Bennett ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mouse Brain ◽  
Three Dimensional ◽  
Magnetic Resonance Microscopy ◽  
Digital Atlas
Sign in / Sign up

Export Citation Format

Share Document