scholarly journals A general method to fine-tune fluorophores for live-cell and in vivo imaging

2017 ◽  
Vol 14 (10) ◽  
pp. 987-994 ◽  
Author(s):  
Jonathan B Grimm ◽  
Anand K Muthusamy ◽  
Yajie Liang ◽  
Timothy A Brown ◽  
William C Lemon ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Live Cell ◽  
Fine Tune ◽  
General Method

scholarly journals A general method to fine-tune fluorophores for live-cell and in vivo imaging

2017 ◽  
Author(s):  
Jonathan B. Grimm ◽  
Anand K. Muthusamy ◽  
Yajie Liang ◽  
Timothy A. Brown ◽  
William C. Lemon ◽  
...  
Keyword(s):  
Fluorescence Microscopy ◽  
In Vivo Imaging ◽  
Chemical Properties ◽  
Live Cell ◽  
Live Cells ◽  
Fine Tune ◽  
General Method ◽  
And Chemical Properties

ABSTRACTPushing the frontier of fluorescence microscopy requires the design of enhanced fluorophores with finely tuned properties. We recently discovered that incorporation of four-membered azetidine rings into classic fluorophore structures elicits substantial increases in brightness and photostability, resulting in the ‘Janelia Fluor’ (JF) series of dyes. Here, we refine and extend this strategy, showing that incorporation of 3-substituted azetidine groups allows rational tuning of the spectral and chemical properties with unprecedented precision. This strategy yields a palette of new fluorescent and fluorogenic labels with excitation ranging from blue to the far-red with utility in live cells, tissue, and animals.

scholarly journals Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

Pharmaceutics ◽  
2011 ◽  
Vol 3 (2) ◽  
pp. 141-170 ◽  
Author(s):  
Beverley Isherwood ◽  
Paul Timpson ◽  
Ewan J McGhee ◽  
Kurt I Anderson ◽  
Marta Canel ◽  
...  
Keyword(s):  
Drug Discovery ◽  
In Vivo Imaging ◽  
Live Cell

scholarly journals HKOCl-3: a fluorescent hypochlorous acid probe for live-cell and in vivo imaging and quantitative application in flow cytometry and a 96-well microplate assay

2016 ◽  
Vol 7 (3) ◽  
pp. 2094-2099 ◽  
Author(s):  
Jun Jacob Hu ◽  
Nai-Kei Wong ◽  
Ming-Yang Lu ◽  
Xingmiao Chen ◽  
Sen Ye ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Hypochlorous Acid ◽  
Live Cell ◽  
Microplate Assay

We describe an ultra-selective and ultra-sensitive HOCI fluorescent probe HKOCl-3 for live-cell and in vivo imaging and quantitative applications.

scholarly journals Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and In Vivo Imaging

ACS Sensors ◽  
2018 ◽  
Vol 3 (10) ◽  
pp. 2118-2128 ◽  
Author(s):  
Shi-Yu Liu ◽  
Hao Xiong ◽  
Jia-Qian Yang ◽  
Shu-Hou Yang ◽  
Yingfu Li ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Near Infrared ◽  
Live Cell ◽  
Fluorogenic Probe

scholarly journals Multimodal optical contrast agents as new tools for monitoring and tuning nanoemulsion internalisation into cancer cells. From live cell imaging to in vivo imaging of tumours

2020 ◽  
Vol 2 (4) ◽  
pp. 1590-1602
Author(s):  
Geoffrey Prévot ◽  
Talia Bsaibess ◽  
Jonathan Daniel ◽  
Coralie Genevois ◽  
Guillaume Clermont ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Cancer Cells ◽  
In Vivo Imaging ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Optical Contrast ◽  
Optical Probes ◽  
Optical Contrast Agents

Tailor-made NIR emitting dyes were designed as multimodal optical probes.

scholarly journals Live‐Cell Imaging: Time‐Gated FRET Nanoprobes for Autofluorescence‐Free Long‐Term In Vivo Imaging of Developing Zebrafish (Adv. Mater. 39/2020)

2020 ◽  
Vol 32 (39) ◽  
pp. 2070291 ◽  
Author(s):  
Marcelina Cardoso Dos Santos ◽  
Ingrid Colin ◽  
Gabriel Ribeiro Dos Santos ◽  
Kimihiro Susumu ◽  
Michaël Demarque ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Imaging Time

Multicoloured fluorescent indicators for live-cell and in vivo imaging of inorganic mercury dynamics

2018 ◽  
Vol 121 ◽  
pp. 26-37
Author(s):  
Rongkun Tao ◽  
Mei Shi ◽  
Yejun Zou ◽  
Di Cheng ◽  
Qiaohui Wang ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Inorganic Mercury ◽  
Live Cell ◽  
Fluorescent Indicators

scholarly journals Quantum Dots for Live Cell and In Vivo Imaging

2009 ◽  
Vol 10 (2) ◽  
pp. 441-491 ◽  
Author(s):  
Maureen Walling ◽  
Jennifer Novak ◽  
Jason R. E. Shepard
Keyword(s):  
Quantum Dots ◽  
In Vivo Imaging ◽  
Live Cell

scholarly journals Evolution of BRET Biosensors from Live Cell to Tissue-Scale In vivo Imaging

2013 ◽  
Vol 4 ◽  
Author(s):  
Abhijit De ◽  
Akshi Jasani ◽  
Rohit Arora ◽  
Sanjiv S. Gambhir
Keyword(s):  
In Vivo Imaging ◽  
Live Cell
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