Whispering-gallery-mode biosensing: label-free detection down to single molecules

2008 ◽  
Vol 5 (7) ◽  
pp. 591-596 ◽  
Author(s):  
Frank Vollmer ◽  
Stephen Arnold
Keyword(s):  
Single Molecules ◽  
Whispering Gallery Mode ◽  
Label Free ◽  
Whispering Gallery ◽  
Label Free Detection

Integration of digital microfluidics with whispering-gallery mode sensors for label-free detection of biomolecules

Lab on a Chip ◽  
2017 ◽  
Vol 17 (10) ◽  
pp. 1740-1748 ◽  
Author(s):  
Sentayehu F. Wondimu ◽  
Sebastian von der Ecken ◽  
Ralf Ahrens ◽  
Wolfgang Freude ◽  
Andreas E. Guber ◽  
...  
Keyword(s):  
Refractive Index ◽  
Digital Microfluidics ◽  
Whispering Gallery Mode ◽  
Label Free ◽  
Biosensor Arrays ◽  
Whispering Gallery ◽  
Label Free Detection ◽  
Detection Of Biomolecules

WGM biosensor arrays are integrated with a DMF system. The viability of the system is demonstrated by refractive-index and biosensing experiments.

Optical whispering gallery mode resonators for label-free detection of water contaminants

2020 ◽  
Vol 126 ◽  
pp. 115856 ◽  
Author(s):  
Simone Berneschi ◽  
Francesca Bettazzi ◽  
Ambra Giannetti ◽  
Francesco Baldini ◽  
Gualtiero Nunzi Conti ◽  
...  
Keyword(s):  
Whispering Gallery Mode ◽  
Label Free ◽  
Water Contaminants ◽  
Whispering Gallery ◽  
Label Free Detection

scholarly journals Review of biosensing with whispering-gallery mode lasers

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Nikita Toropov ◽  
Gema Cabello ◽  
Mariana P. Serrano ◽  
Rithvik R. Gutha ◽  
Matías Rafti ◽  
...  
Keyword(s):  
Biological Samples ◽  
Whispering Gallery Mode ◽  
Photonic Devices ◽  
Whispering Gallery Modes ◽  
Label Free ◽  
Virus Particles ◽  
Whispering Gallery ◽  
Label Free Detection ◽  
Basic Concepts ◽  
Wgm Resonators

AbstractLasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) are miniature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular electrostatic changes at biointerfaces, and barcode-type live-cell tagging and tracking. The most recent advances in biosensing with WGM microlasers are described in this review. We cover the basic concepts of WGM resonators, the integration of gain media into various active WGM sensors and devices, and the cutting-edge advances in photonic devices for micro- and nanoprobing of biological samples that can be integrated with WGM lasers.

The whispering gallery mode biosensor: label-free detection from virus to single protein

2014 ◽  
Author(s):  
S. Holler ◽  
V. R. Dantham ◽  
D. Keng ◽  
V. Kolchenko ◽  
S. Arnold ◽  
...  
Keyword(s):  
Whispering Gallery Mode ◽  
Label Free ◽  
Whispering Gallery ◽  
Label Free Detection ◽  
Single Protein

Simulation of Whispering-Gallery Mode Microsensing in a Microfluidic System

2009 ◽  
Author(s):  
Lei Huang ◽  
Zhixiong Guo
Keyword(s):  
Electromagnetic Waves ◽  
Whispering Gallery Mode ◽  
Resonance Wavelength ◽  
Microfluidic System ◽  
Wavelength Shift ◽  
Label Free ◽  
Helmholtz Equations ◽  
Fluidic Channel ◽  
Whispering Gallery ◽  
Label Free Detection

Label-free detection using a whispering-gallery mode biosensor in a micro fluidic channel is simulated. The analyte transport in the solution is controlled by applied electric potentials and diffusion. The finite element method is employed for solving the charged species transportation equations, the Poisson equation, the equations of conservation of momentum and energy, and the Helmholtz equations for electromagnetic waves. The adsorption process of analyte on the micro resonator surface is monitored by the resonance wavelength shift in the sensor. Shift caused by temperature variation due to Joule heating is found to be negligible compared to that induced by analyte deposition. The deposition induced shifts behave in a manner similar to Langmuir-like adsorption kinetics. A linear correlation between the frequency shift and the analyte concentration in the solution is obtained. The applied voltage is found to affect the adsorption capability; and thus, the sensor sensitivity. Detection of very low concentration to the sub-ppm level using the sensor is demonstrated.

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