Sema3a maintains normal heart rhythm through sympathetic innervation patterning

2007 ◽  
Vol 13 (5) ◽  
pp. 604-612 ◽  
Author(s):  
Masaki Ieda ◽  
Hideaki Kanazawa ◽  
Kensuke Kimura ◽  
Fumiyuki Hattori ◽  
Yasuyo Ieda ◽  
...  
Keyword(s):  
Sympathetic Innervation ◽  
Heart Rhythm ◽  
Normal Heart

scholarly journals Optogenetic Cardiac Pacing and Its Applications

2021 ◽  
pp. 1-4
Author(s):  
Airong Li ◽  
◽  
Rudolph E Tanzi ◽  
Keyword(s):  
Animal Model ◽  
Heart Rhythm ◽  
Cardiac Pacing ◽  
Clinical Translation ◽  
Normal Heart ◽  
Living Tissues

Optogenetics combines the biological techniques of optics and genetics and uses light to control the activities of living tissues such as neurons and heart. Optogenetic actuators including channelrhodopsin (ChR), halorhodopsin (NpHR), and archaerhodopsin specifically provide for neuronal or cardiac controls. The clinical translation of cardiac optogenetics will include human and larger mammalian animal model applications and ultimately optogenetics may have the power to restore normal heart rhythm.

Extrasystoles

2018 ◽  
Author(s):  
Moutaz El-Kadri ◽  
George Hart
Keyword(s):  
Sinus Node ◽  
Heart Rhythm ◽  
Normal Heart ◽  
Atrioventricular Junction ◽  
Premature Ventricular Complexes ◽  
Electrical Impulse ◽  
Ventricular Extrasystoles

An extrasystole is a cardiac electrical impulse (often premature) which is not part of the normal heart rhythm. Extrasystoles most frequently arise from the ventricles and are then called ventricular extrasystoles, or premature ventricular complexes. Less often, they originate from the atria, the atrioventricular junction or, rarely, from the sinus node—these are termed supraventricular extrasystoles. The term ‘bigeminy’ refers to an extrasystole every second beat, and ‘trigeminy’, every third beat. Two successive extrasystoles are called a ‘couplet’; three are called a ‘triplet’. Extrasystoles with varying morphology are described as ‘polymorphic’ or ‘multifocal’, whereas those maintaining the same morphology are termed ‘unifocal’.

scholarly journals Weighing In The Evidence: Lifestyle Modification In The Treatment Of Atrial Fibrillation

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Kathryn Hong
Keyword(s):  
Lifestyle Modification ◽  
Pulmonary Veins ◽  
Heart Rhythm ◽  
Fold Increase ◽  
Normal Heart ◽  
Electrical Transmission ◽  
Sa Node ◽  
Normal Heart Rate ◽  
Canadian Population ◽  
Electrical Impulses

Imagine if you suddenly felt your heart “jumping out of your chest” – this is the case for an estimated 1 in 4 Canadians who experience this rapid and chaotic heartbeat characteristic of atrial brillation (AF). The healthy heart works continuously to beat regularly under the control of electrical impulses originating from the sinoatrial (SA) node, the heart’s natural pacemaker. In AF, electrical impulses do not originate in the SA node, but rather, from a different part of the atrium or in nearby pulmonary veins. These abnormal electrical signals become rapid and disorganized, radiating throughout the atrial walls in an uncoordinated manner. This can cause the walls of the atrium to quiver, or brillate, which results in irregular electrical transmission from the atria to the ventricles. A normal heart rate at rest should be between 60-100 beats per minute at rest, but in AF, it can be considerably higher than 140 beats per minute1. Affecting more than 33 million individuals worldwide, AF is the most common sustained irregular heart rhythm encountered in clinical practice2. The progression and maintenance of AF results in adverse events, including an increase in hospitalizations and a ve-fold increase in the risk of stroke3. Given this evidence and anticipated increases in life expectancy within the next several decades, there are clear public health implications for the aging Canadian population.

scholarly journals Reducing Risk of Stroke When You Have Atrial Fibrillation - Evidence Update for Patients

2020 ◽  
Author(s):  
Keyword(s):  
Atrial Fibrillation ◽  
Atrial Flutter ◽  
Heart Rhythm ◽  
Normal Heart

People with atrial fibrillation (AFib) or atrial flutter are five times more likely to experience a stroke compared with people who have a normal heart rhythm. The risk of stroke increases with age. Medicines that keep the blood from clotting, called anticoagulants, lower the risk of stroke but can also cause serious bleeding.

Tarka® overdose in a young child

2010 ◽  
Vol 30 (9) ◽  
pp. 1392-1398 ◽  
Author(s):  
Murat Doğan ◽  
Murat Basaranoglu ◽  
Erdal Peker ◽  
Sinan Akbayram ◽  
Musa Sahin ◽  
...  
Keyword(s):  
Antihypertensive Medication ◽  
Normal Values ◽  
Heart Rhythm ◽  
Fixed Dose ◽  
Normal Heart ◽  
Accidental Ingestion ◽  
Verapamil Hydrochloride ◽  
Toxic Dose ◽  
Temporary Pacemaker ◽  
Dose Combination

Tarka® is a combination antihypertensive medication composed of verapamil hydrochloride and trandolapril. A 3.5-year-old female was brought to our hospital due to a sleepy condition 7 hours after an accidental ingestion of six tablets of Tarka® containing 240 mg verapamil hydrochloride and 4 mg trandolapril in each tablet. Five hours after hospitalization, her condition deteriorated and arterial pressure progressively decreased despite the treatment. Finally, a temporary pacemaker was implanted, after which the vital findings began to return to normal values. The pacemaker was removed 13 hours after implantation as normal heart rhythm was observed. There are no reports of intoxication with fixed-dose combination products, especially Tarka®, in young children in the literature. Therefore, we believe that our report can provide an insight on the toxic dose of this drug in younger children. Clinicians should keep in mind that lethargy can be the first symptom of a possible clinical deterioration, even in normotensive and normorhythmic individuals.

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