Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury

1995 ◽  
Vol 1 (2) ◽  
pp. 154-158 ◽  
Author(s):  
Lenard M. Lichtenberger ◽  
Zu-Mo Wang ◽  
Jimmy J. Romero ◽  
Carlos Ulloa ◽  
Joseph C. Perez ◽  
...  
Keyword(s):  
Gastrointestinal Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Insight Into

A New Insight into Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) as Modulated Green Inhibitory Agent on Mild Steel Corrosion

2019 ◽  
Vol 4 (19) ◽  
pp. 5799-5809
Author(s):  
Dhruvi Patel ◽  
Krutarth Makwana ◽  
Manjusha B. Shirdhonkar ◽  
Ketan C. Kuperkar
Keyword(s):  
Mild Steel ◽  
Steel Corrosion ◽  
Mild Steel Corrosion ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Insight Into

scholarly journals Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice

2012 ◽  
Vol 168 (1) ◽  
pp. 225-237 ◽  
Author(s):  
Sabrina Cipriani ◽  
Andrea Mencarelli ◽  
Angela Bruno ◽  
Barbara Renga ◽  
Eleonora Distrutti ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Receptor ◽  
Gastrointestinal Injury ◽  
Inflammatory Drugs ◽  
Bile Acid Receptor ◽  
Anti Inflammatory

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

10.1038/70995 ◽  
1999 ◽  
Vol 5 (12) ◽  
pp. 1418-1423 ◽  
Author(s):  
Michael K. Jones ◽  
Hongtao Wang ◽  
Brigitta M. Peskar ◽  
Ellis Levin ◽  
Rabiha M. Itani ◽  
...  
Keyword(s):  
Ulcer Healing ◽  
Cancer Growth ◽  
Inhibition Of Angiogenesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Insight Into

scholarly journals Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice

2011 ◽  
Vol 164 (8) ◽  
pp. 1929-1938 ◽  
Author(s):  
Stefano Fiorucci ◽  
Andrea Mencarelli ◽  
Sabrina Cipriani ◽  
Barbara Renga ◽  
Giuseppe Palladino ◽  
...  
Keyword(s):  
Farnesoid X Receptor ◽  
Gastrointestinal Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Current Perspectives in NSAID-Induced Gastropathy

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Mau Sinha ◽  
Lovely Gautam ◽  
Prakash Kumar Shukla ◽  
Punit Kaur ◽  
Sujata Sharma ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Preventive Measures ◽  
Gastrointestinal Complications ◽  
Gastrointestinal Injury ◽  
Novel Drugs ◽  
The World ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. Though several approaches for limiting these side effects have been adopted, like the use of COX-2 specific drugs, comedication of acid suppressants like proton pump inhibitors and prostaglandin analogs, these alternatives have limitations in terms of efficacy and side effects. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides the information on different preventive measures prescribed to minimize such adverse effects and analyses the new suggested strategies for development of novel drugs to maintain the anti-inflammatory functions of NSAIDs along with effective gastrointestinal protection.

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