Failure to Renew Prescriptions for Gastroprotective Agents to Patients on Continuous Nonsteroidal Anti-inflammatory Drugs Increases Rate of Upper Gastrointestinal Injury

2013 ◽  
Vol 11 (5) ◽  
pp. 499-504.e1 ◽  
Author(s):  
Isabelle Le Ray ◽  
Alan N. Barkun ◽  
Françoise Vauzelle–Kervroëdan ◽  
Marc Bardou
Keyword(s):  
Gastrointestinal Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Upper Gastrointestinal

Adverse reactions with the use of non-steroidal anti-inflammatory drugs

2020 ◽  
pp. 35-50
Author(s):  
M. L. Maksimov ◽  
N. M. Kiseleva ◽  
D. G. Semenikhin ◽  
B. K. Romanov
Keyword(s):  
Risk Factors ◽  
Adverse Reactions ◽  
Effective Prevention ◽  
Chemical Structures ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Prevention Method ◽  
Effective Medication ◽  
Upper Gastrointestinal

Non-steroidal anti-inflammatory drugs (NSAIDs) are included in a pharmacological group of drugs with different chemical structures providing anti-inflammatory, analgesic and antipyretic actions, as well as antiplatelet action to a certain degree. Unfortunately, NSAIDs can cause a wide range of adverse reactions (AR) posing a serious risk to the health and life of patients. Therefore, the rational use of NSAIDs should include methods for effective prevention of drug complications. Many NSAIDs have a pronounced therapeutic effect, simultaneously causing many undesirable effects, so the drug shall be chosen considering the development of predicted side effects and modern algorithms. According to clinical recommendations, risk factors and administration of safer NSAIDs shall be considered as the main prevention method. Besides, it is possible to protect the patient from the upper gastrointestinal tract complications using proton pump inhibitors. It should be noted that there are no effective medication methods for kidney and liver protection to reduce the risk of NSAID-associated complications.

Clinical and economic implications of upper gastrointestinal adverse events in Asian rheumatological patients on long-term non-steroidal anti-inflammatory drugs

2018 ◽  
Vol 21 (5) ◽  
pp. 943-951 ◽  
Author(s):  
Lydia Say Lee Pok ◽  
Fatiha Hana Shabaruddin ◽  
Maznah Dahlui ◽  
Sargunan Sockalingam ◽  
Mohd Shahrir Mohamed Said ◽  
...  
Keyword(s):  
Adverse Events ◽  
Economic Implications ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Gastrointestinal Adverse Events ◽  
Upper Gastrointestinal

Osteoarthritis in Older Adults: Nonsteroidal Anti-Inflammatory Drugs Versus Opioids

2019 ◽  
Vol 34 (10) ◽  
pp. 674-677
Author(s):  
Callan Banks ◽  
Krystal Hughes ◽  
Cassandra Simpkins ◽  
David P. Elliott
Keyword(s):  
Older Adults ◽  
Treatment Option ◽  
Treatment Options ◽  
Persistent Pain ◽  
Careful Monitoring ◽  
Patient Profile ◽  
Central Nervous System Depression ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Upper Gastrointestinal

Persistent pain in older adults as a result of osteoarthritis (OA) has various treatment options, and all of them have significant risks. An oral nonsteroidal anti-inflammatory drug (NSAID) or an opioid can be considered as a treatment option when persistent pain is not controlled by nonpharmacological interventions and regularly scheduled doses of acetaminophen. However, NSAIDs are nephrotoxic and may cause upper gastrointestinal bleeding. These risks can be mitigated through the initiation of a proton-pump inhibitor and careful monitoring of renal function and serum electrolytes. A low-dose opioid taken as needed can be considered as a treatment option if the pain is not controlled by NSAIDs as long as the risks associated with central nervous system depression and dose escalation as a result of tolerance are monitored closely. The complete patient profile must be taken into consideration when determining the best option.

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