scholarly journals Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

2017 ◽  
Vol 23 (8) ◽  
pp. 917-928 ◽  
Author(s):  
Benjamin Blasco ◽  
Didier Leroy ◽  
David A Fidock
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Antimalarial Drug ◽  
Antimalarial Drug Resistance ◽  
Plasmodium Falciparum Parasite ◽  
Parasite Biology ◽  
Falciparum Parasite

History and current status of Plasmodium falciparum antimalarial drug resistance in Madagascar

2010 ◽  
Vol 42 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Valérie Andriantsoanirina ◽  
Didier Ménard ◽  
Luciano Tuseo ◽  
Rémy Durand
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Antimalarial Drug ◽  
Current Status ◽  
Antimalarial Drug Resistance

scholarly journals Molecular Surveillance of Drug Resistance of Plasmodium falciparum Isolates Imported from Angola in Henan Province, China

2019 ◽  
Vol 63 (10) ◽  
Author(s):  
Ruimin Zhou ◽  
Chengyun Yang ◽  
Suhua Li ◽  
Yuling Zhao ◽  
Ying Liu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Antimalarial Drug ◽  
Henan Province ◽  
Nucleotide Polymorphisms ◽  
Combination Therapies ◽  
Antimalarial Drug Resistance ◽  
Single Nucleotide ◽  
Molecular Surveillance ◽  
Content Type

ABSTRACT Angola was the main origin country for the imported malaria in Henan Province, China. Antimalarial drug resistance has posed a threat to the control and elimination of malaria. Several molecular markers were confirmed to be associated with the antimalarial drug resistance, such as pfcrt, pfmdr1, pfdhfr, pfdhps, and K13. This study evaluated the drug resistance of the 180 imported Plasmodium falciparum isolates from Angola via nested PCR using Sanger sequencing. The prevalences of pfcrt C72V73M74N75K76, pfmdr1 N86Y184S1034N1042D1246, pfdhfr A16N51C59S108D139I164, and pfdhps S436A437A476K540A581 were 69.4%, 59.9%, 1.3% and 6.3%, respectively. Three nonsynonymous (A578S, M579I, and Q613E) and one synonymous (R471R) mutation of K13 were found, the prevalences of which were 2.5% and 1.3%, respectively. The single nucleotide polymorphisms (SNPs) in pfcrt, pfmdr1, pfdhfr, and pfdhps were generally shown as multiple mutations. The mutant prevalence of pfcrt reduced gradually, but pfdhfr and pfdhps still showed high mutant prevalence, while pfmdr1 was relatively low. The mutation of the K13 gene was rare. Molecular surveillance of artemisinin (ART) resistance will be used as a tool to evaluate the real-time efficacy of the artemisinin-based combination therapies (ACTs) and the ART resistance situation.

Molecular surveillance of antimalarial drug resistance related genes in Plasmodium falciparum isolates from Eritrea

Acta Tropica ◽  
2016 ◽  
Vol 157 ◽  
pp. 158-161 ◽  
Author(s):  
Michela Menegon ◽  
Abduselam M. Nurahmed ◽  
Albadawi A. Talha ◽  
Bakri Y.M. Nour ◽  
Carlo Severini
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Antimalarial Drug ◽  
Antimalarial Drug Resistance ◽  
Molecular Surveillance

Molecular monitoring of antimalarial drug resistance among Plasmodium falciparum field isolates from Odisha, India

Acta Tropica ◽  
2013 ◽  
Vol 126 (1) ◽  
pp. 84-87 ◽  
Author(s):  
Sasmita Kumari Das Sutar ◽  
Gunanidhi Dhangadamajhi ◽  
Shantanu Kumar Kar ◽  
Manoranjan Ranjit
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Antimalarial Drug ◽  
Molecular Monitoring ◽  
Antimalarial Drug Resistance ◽  
Field Isolates

scholarly journals Antimalarial drug resistance of Plasmodium falciparum in India: changes over time and space

2011 ◽  
Vol 11 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Naman K Shah ◽  
Gajender PS Dhillon ◽  
Adtiya P Dash ◽  
Usha Arora ◽  
Steven R Meshnick ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Antimalarial Drug ◽  
Time And Space ◽  
Antimalarial Drug Resistance ◽  
Changes Over Time ◽  
Over Time
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