scholarly journals α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

2017 ◽  
Vol 23 (3) ◽  
pp. 288-290 ◽  
Author(s):  
Tiffany Zee ◽  
Neelanjan Bose ◽  
Jarcy Zee ◽  
Jennifer N Beck ◽  
See Yang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Lipoic Acid ◽  
Acid Treatment ◽  
Cystine Urolithiasis

scholarly journals α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

2017 ◽  
Author(s):  
Tiffany Zee ◽  
Neelanjan Bose ◽  
Jarcy Zee ◽  
Jennifer N. Beck ◽  
See Yang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Effective Treatment ◽  
Lipoic Acid ◽  
Acid Treatment ◽  
Stone Formation ◽  
Cystine Urolithiasis

Excess urinary cystine can lead to painful stone formation. There is no current effective treatment, but here Pankaj Kapahi, Marshall Stoller and colleagues have found that α-lipoic acid can prevent or even reverse formation of these stones in a mouse model.

Therapeutic potential of α-lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis

2017 ◽  
Vol 7 (11) ◽  
pp. 1095-1103
Author(s):  
Toshiaki Nakano ◽  
Li-Wen Hsu ◽  
Chia-Yun Lai ◽  
Yuki Takaoka ◽  
Masafumi Inomata ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Acid Derivative ◽  
Lipoic Acid ◽  
Therapeutic Potential ◽  
Sodium Zinc

scholarly journals Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Maria C. Guido ◽  
Victor Debbas ◽  
Vera M. Salemi ◽  
Elaine R. Tavares ◽  
Thayna Meirelles ◽  
...  
Keyword(s):  
Mouse Model ◽  
Marfan Syndrome ◽  
Lipoic Acid ◽  
Elastic Fiber ◽  
Aortic Aneurysms ◽  
Ros Generation ◽  
Ros Production ◽  
Aortic Dilation ◽  
Advanced Stages ◽  
Aortic Remodeling

Marfan syndrome (MFS) cardiovascular manifestations such as aortic aneurysms and cardiomyopathy carry substantial morbidity/mortality. We investigated the effects of lipoic acid, an antioxidant, on ROS production and aortic remodeling in a MFS mgΔloxPneo mouse model. MFS and WT (wild-type) 1-month-old mice were allocated to 3 groups: untreated, treated with losartan, and treated with lipoic acid. At 6 months old, echocardiography, ROS production, and morphological analysis of aortas were performed. Aortic ROS generation in 6-month-old MFS animals was higher at advanced stages of disease in MFS. An unprecedented finding in MFS mice analyzed by OCT was the occurrence of focal inhomogeneous regions in the aortic arch, either collagen-rich extremely thickened or collagen-poor hypotrophic regions. MFS animals treated with lipoic acid showed markedly reduced ROS production and lower ERK1/2 phosphorylation; meanwhile, aortic dilation and elastic fiber breakdown were unaltered. Of note, lipoic acid treatment associated with the absence of focal inhomogeneous regions in MFS animals. Losartan reduced aortic dilation and elastic fiber breakdown despite no change in ROS generation. In conclusion, oxidant generation by itself seems neutral with respect to aneurysm progression in MFS; however, lipoic acid-mediated reduction of inhomogeneous regions may potentially associate with less anisotropy and reduced chance of dissection/rupture.

α-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma

2004 ◽  
Vol 114 (2) ◽  
pp. 429-435 ◽  
Author(s):  
You Sook Cho ◽  
Jaechun Lee ◽  
Tae-Hoon Lee ◽  
Eun Young Lee ◽  
Ki-Up Lee ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Lipoic Acid

scholarly journals Combined application of polyacrylate scaffold and lipoic acid treatment promotes neural tissue reparation after brain injury

Brain Injury ◽  
2016 ◽  
Vol 30 (2) ◽  
pp. 208-216 ◽  
Author(s):  
Brenda Rocamonde ◽  
Sara Paradells ◽  
M. Angeles Garcia Esparza ◽  
Mavi Sánchez Vives ◽  
Salvatore Sauro ◽  
...  
Keyword(s):  
Brain Injury ◽  
Lipoic Acid ◽  
Acid Treatment ◽  
Neural Tissue ◽  
Combined Application
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