Therapeutic potential of α-lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis

2017 ◽  
Vol 7 (11) ◽  
pp. 1095-1103
Author(s):  
Toshiaki Nakano ◽  
Li-Wen Hsu ◽  
Chia-Yun Lai ◽  
Yuki Takaoka ◽  
Masafumi Inomata ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Acid Derivative ◽  
Lipoic Acid ◽  
Therapeutic Potential ◽  
Sodium Zinc

The α-Lipoic acid derivative sodium zinc dihydrolipoylhistidinate reduces chemotherapy-induced alopecia in a rat model: A pilot study

Surgery Today ◽  
2011 ◽  
Vol 41 (5) ◽  
pp. 693-697 ◽  
Author(s):  
Satoshi Hagiwara ◽  
Tomohisa Uchida ◽  
Hironori Koga ◽  
Masafumi Inomata ◽  
Fumitaka Yoshizumi ◽  
...  
Keyword(s):  
Pilot Study ◽  
Acid Derivative ◽  
Lipoic Acid ◽  
Rat Model ◽  
Sodium Zinc

New lipoic acid derivative drug sodium zinc dihydrolipoylhistidinate prevents cardiac dysfunction in an isolated perfused rat heart model*

2011 ◽  
Vol 39 (3) ◽  
pp. 506-511 ◽  
Author(s):  
Satoshi Hagiwara ◽  
Yasushi Teshima ◽  
Naohiko Takahashi ◽  
Hironori Koga ◽  
Tetsunori Saikawa ◽  
...  
Keyword(s):  
Acid Derivative ◽  
Lipoic Acid ◽  
Cardiac Dysfunction ◽  
Rat Heart ◽  
Heart Model ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Sodium Zinc

The therapeutic potential of resveratrol in a mouse model of melanoma lung metastasis

2020 ◽  
Vol 88 ◽  
pp. 106905 ◽  
Author(s):  
Amirhossein Davoodvandi ◽  
Maryam Darvish ◽  
Sarina Borran ◽  
Majid Nejati ◽  
Samaneh Mazaheri ◽  
...  
Keyword(s):  
Mouse Model ◽  
Lung Metastasis ◽  
Therapeutic Potential

scholarly journals Therapeutic Potential of Magnetic Nanoparticle-Based Human Adipose-Derived Stem Cells in a Mouse Model of Parkinson’s Disease

2021 ◽  
Vol 22 (2) ◽  
pp. 654
Author(s):  
Ka Young Kim ◽  
Keun-A Chang
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Magnetic Nanoparticles ◽  
Substantia Nigra ◽  
Mouse Model ◽  
Magnetic Nanoparticle ◽  
Imaging System ◽  
Therapeutic Potential ◽  
Adipose Derived Stem Cells

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. Several treatments for PD have focused on the management of physical symptoms using dopaminergic agents. However, these treatments induce various adverse effects, including hallucinations and cognitive impairment, owing to non-targeted brain delivery, while alleviating motor symptoms. Furthermore, these therapies are not considered ultimate cures owing to limited brain self-repair and regeneration abilities. In the present study, we aimed to investigate the therapeutic potential of human adipose-derived stem cells (hASCs) using magnetic nanoparticles in a 6-hydroxydopamine (6-OHDA)-induced PD mouse model. We used the Maestro imaging system and magnetic resonance imaging (MRI) for in vivo tracking after transplantation of magnetic nanoparticle-loaded hASCs to the PD mouse model. The Maestro imaging system revealed strong hASCs signals in the brains of PD model mice. In particular, MRI revealed hASCs distribution in the substantia nigra of hASCs-injected PD mice. Behavioral evaluations, including apomorphine-induced rotation and rotarod performance, were significantly recovered in hASCs-injected 6-OHDA induced PD mice when compared with saline-treated counterparts. Herein, we investigated whether hASCs transplantation using magnetic nanoparticles recovered motor functions through targeted brain distribution in a 6-OHDA induced PD mice. These results indicate that magnetic nanoparticle-based hASCs transplantation could be a potential therapeutic strategy in PD.

MAPK/AP-1-Targeted Anti-Inflammatory Activities of Xanthium strumarium

2016 ◽  
Vol 44 (06) ◽  
pp. 1111-1125 ◽  
Author(s):  
Muhammad Jahangir Hossen ◽  
Mi-Yeon Kim ◽  
Jae Youl Cho
Keyword(s):  
Mouse Model ◽  
Therapeutic Potential ◽  
Inflammatory Diseases ◽  
Elevated Serum ◽  
Human Monocyte ◽  
Serum Levels ◽  
Mitogen Activated Protein Kinase ◽  
Xanthium Strumarium ◽  
U937 Cells ◽  
Anti Inflammatory

Xanthium strumarium L. (Asteraceae), a traditional Chinese medicine, is prescribed to treat arthritis, bronchitis, and rhinitis. Although the plant has been used for many years, the mechanism by which it ameliorates various inflammatory diseases is not yet fully understood. To explore the anti-inflammatory mechanism of methanol extracts of X. strumarium (Xs-ME) and its therapeutic potential, we used lipopolysaccharide (LPS)-stimulated murine macrophage-like RAW264.7 cells and human monocyte-like U937 cells as well as a LPS/D-galactosamine (GalN)-induced acute hepatitis mouse model. To find the target inflammatory pathway, we used holistic immunoblotting analysis, reporter gene assays, and mRNA analysis. Xs-ME significantly suppressed the up-regulation of both the activator protein (AP)-1-mediated luciferase activity and the production of LPS-induced proinflammatory cytokines, including interleukin (IL)-1[Formula: see text], IL-6, and tumor necrosis factor (TNF)-[Formula: see text]. Moreover, Xs-ME strongly inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) in LPS-stimulated RAW264.7 and U937 cells. Additionally, these results highlighted the hepatoprotective and curative effects of Xs-ME in a mouse model of LPS/D-GalN-induced acute liver injury, as assessed by elevated serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and histological damage. Therefore, our results strongly suggest that the ethnopharmacological roles of Xs-ME in hepatitis and other inflammatory diseases might result from its inhibitory activities on the inflammatory signaling of MAPK and AP-1.

Therapeutic potential of cell-type selective optogenetics for a mouse model with urinary frequency

2021 ◽  
Vol 79 ◽  
pp. S15
Author(s):  
H. Shimura ◽  
S. Manita ◽  
T. Mochizuki ◽  
Y. Matsuda ◽  
T. Ihara ◽  
...  
Keyword(s):  
Mouse Model ◽  
Therapeutic Potential ◽  
Cell Type ◽  
Urinary Frequency
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