scholarly journals Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy

2014 ◽  
Vol 20 (4) ◽  
pp. 443-449 ◽  
Author(s):  
Aaron J Schain ◽  
Robert A Hill ◽  
Jaime Grutzendler
Keyword(s):  
In Vivo Imaging ◽  
Label Free ◽  
Myelinated Axons ◽  
Confocal Reflectance Microscopy ◽  
Health And Disease ◽  
Reflectance Microscopy

scholarly journals Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo

2003 ◽  
Vol 11 (24) ◽  
pp. 3171 ◽  
Author(s):  
Kung-Bin Sung ◽  
Rebecca Richards-Kortum ◽  
Michele Follen ◽  
Anais Malpica ◽  
Chen Liang ◽  
...  
Keyword(s):  
Real Time ◽  
Fiber Optic ◽  
Squamous Epithelium ◽  
Nuclear Morphology ◽  
Confocal Reflectance Microscopy ◽  
Reflectance Microscopy

Label-free in vivo imaging of Drosophila melanogaster by multiphoton microscopy

2008 ◽  
Author(s):  
Chiao-Ying Lin ◽  
Vladimir Hovhannisyan ◽  
June-Tai Wu ◽  
Sung-Jan Lin ◽  
Chii-Wann Lin ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
In Vivo Imaging ◽  
Multiphoton Microscopy ◽  
Label Free

scholarly journals Label-free nanoscale optical metrology on myelinated axons in vivo

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Junhwan Kwon ◽  
Moonseok Kim ◽  
Hyejin Park ◽  
Bok-Man Kang ◽  
Yongjae Jo ◽  
...  
Keyword(s):  
Optical Metrology ◽  
Label Free ◽  
Myelinated Axons

scholarly journals Label-free microscopic assessment of glioblastoma biopsy specimens prior to biobanking

2014 ◽  
Vol 36 (2) ◽  
pp. E8 ◽  
Author(s):  
Joseph Georges ◽  
Aqib Zehri ◽  
Elizabeth Carlson ◽  
Joshua Nichols ◽  
Michael A. Mooney ◽  
...  
Keyword(s):  
Patient Survival ◽  
Imaging Modality ◽  
Primary Brain Tumor ◽  
Label Free ◽  
Confocal Reflectance Microscopy ◽  
Molecular Therapies ◽  
Targeted Molecular Therapies ◽  
Reflectance Microscopy ◽  
And Storage

Glioblastoma is the most common primary brain tumor with a median 12- to 15-month patient survival. Improving patient survival involves better understanding the biological mechanisms of glioblastoma tumorigenesis and seeking targeted molecular therapies. Central to furthering these advances is the collection and storage of surgical biopsies (biobanking) for research. This paper addresses an imaging modality, confocal reflectance microscopy (CRM), for safely screening glioblastoma biopsy samples prior to biobanking to increase the quality of tissue provided for research and clinical trials. These data indicate that CRM can immediately identify cellularity of tissue biopsies from animal models of glioblastoma. When screening fresh human biopsy samples, CRM can differentiate a cellular glioblastoma biopsy from a necrotic biopsy without altering DNA, RNA, or protein expression of sampled tissue. These data illustrate CRM's potential for rapidly and safely screening clinical biopsy samples prior to biobanking, which demonstrates its potential as an effective screening technique that can improve the quality of tissue biobanked for patients with glioblastoma.

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