scholarly journals Positive selection of MHC class Ib–restricted CD8+ T cells on hematopoietic cells

10.1038/ni814 ◽  
2002 ◽  
Vol 3 (8) ◽  
pp. 772-779 ◽  
Author(s):  
Kevin B. Urdahl ◽  
Joseph C. Sun ◽  
Michael J. Bevan
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Hematopoietic Cells ◽  
Mhc Class Ib ◽  
Class Ib ◽  
Selection Of

scholarly journals Positive selection of self-antigen-specific CD8+T cells by hematopoietic cells

2013 ◽  
Vol 43 (8) ◽  
pp. 2033-2042
Author(s):  
Hisakata Yamada ◽  
Kensuke Shibata ◽  
Koji Sakuraba ◽  
Kenjiro Fujimura ◽  
Yasunobu Yoshikai
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Hematopoietic Cells ◽  
Self Antigen ◽  
Selection Of

Positive Selection of Vβ2+ CD8+ T cells

1992 ◽  
Vol 4 (10) ◽  
pp. 1195-1198 ◽  
Author(s):  
Kyuhei Tomonari
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Selection Of

scholarly journals Impaired response to Listeria in H2-M3–deficient mice reveals a nonredundant role of MHC class Ib–specific T cells in host defense

2006 ◽  
Vol 203 (2) ◽  
pp. 449-459 ◽  
Author(s):  
Honglin Xu ◽  
Taehoon Chun ◽  
Hak-Jong Choi ◽  
Bin Wang ◽  
Chyung-Ru Wang
Keyword(s):  
T Cells ◽  
T Cell ◽  
Host Defense ◽  
Cd8 T Cells ◽  
Mhc Class Ib ◽  
Cell Responses ◽  
Mhc Class Ia ◽  
Deficient Mice ◽  
Class Ib

The major histocompatibility complex (MHC) class Ib molecule H2-M3 primes the rapid expansion of CD8+ T cells by presenting N-formylated bacterial peptides. However, the significance of H2-M3–restricted T cells in host defense against bacteria is unclear. We generated H2-M3–deficient mice to investigate the role of H2-M3 in immunity against Listeria monocytogenes (LM), a model intracellular bacterial pathogen. H2-M3–deficient mice are impaired in early bacterial clearance during primary infection, with diminished LM-specific CD8+ T cell responses and compromised innate immune functions. Although H2-M3–restricted CD8+ T cells constitute a significant proportion of the anti-listerial CD8+ T cell repertoire, the kinetics and magnitude of MHC class Ia–restricted T cell responses are not altered in H2-M3–deficient mice. The fact that MHC class Ia–restricted responses cannot compensate for the H2-M3–mediated immunity suggests a nonredundant role of H2-M3 in the protective immunity against LM. Thus, the early H2-M3–restricted response temporally bridges the gap between innate and adaptive immune responses, subsequently affecting the function of both branches of the immune system.

Positive selection of Tcrb-V4+CD8+ T cells by H-2d molecules

1990 ◽  
Vol 32 (4) ◽  
Author(s):  
Kyuhei Tomonari ◽  
Sue Fairchild
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Selection Of

Repertoire-Determining Role of Peptide in the Positive Selection of CD8+ T cells

1993 ◽  
Vol 135 (1) ◽  
pp. 157-182 ◽  
Author(s):  
Philip G. Ashton-Rickardt ◽  
Luc Van Kaer ◽  
Ton N. M. Schumacher ◽  
Hidde L. Ploegh ◽  
Susumu Tonegawa
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Selection Of

scholarly journals An MHC class Ib–restricted CD8 T cell response confers antiviral immunity

2008 ◽  
Vol 205 (7) ◽  
pp. 1647-1657 ◽  
Author(s):  
Phillip A. Swanson ◽  
Christopher D. Pack ◽  
Annette Hadley ◽  
Chyung-Ru Wang ◽  
Iwona Stroynowski ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Mhc Class Ib ◽  
Wild Type ◽  
Mhc Class Ia ◽  
Class Ib

Although immunity against intracellular pathogens is primarily provided by CD8 T lymphocytes that recognize pathogen-derived peptides presented by major histocompatibility complex (MHC) class Ia molecules, MHC class Ib–restricted CD8 T cells have been implicated in antiviral immunity. Using mouse polyoma virus (PyV), we found that MHC class Ia–deficient (Kb−/−Db−/−) mice efficiently control this persistently infecting mouse pathogen. CD8 T cell depletion mitigates clearance of PyV in Kb−/−Db−/− mice. We identified the ligand for PyV-specific CD8 T cells in Kb−/−Db−/− mice as a nonamer peptide from the VP2 capsid protein presented by Q9, a member of the β2 microglobulin–associated Qa-2 family. Using Q9-VP2 tetramers, we monitored delayed but progressive expansion of these antigen-specific CD8αβ T cells in Kb−/−Db−/− mice. Importantly, we demonstrate that Q9-VP2–specific CD8 T cells more effectively clear wild-type PyV than a VP2 epitopenull mutant PyV. Finally, we show that wild-type mice also generate Q9-restricted VP2 epitope–specific CD8 T cells to PyV infection. To our knowledge, this is the first evidence for a defined MHC class Ib–restricted antiviral CD8 T cell response that contributes to host defense. This study motivates efforts to uncover MHC class Ib–restricted CD8 T cell responses in other viral infections, and given the limited polymorphism of MHC class Ib molecules, it raises the possibility of developing peptide-based viral vaccines having broad coverage across MHC haplotypes.

scholarly journals Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.

1989 ◽  
Vol 170 (1) ◽  
pp. 135-143 ◽  
Author(s):  
N S Liao ◽  
J Maltzman ◽  
D H Raulet
Keyword(s):  
T Cells ◽  
T Cell ◽  
Positive Selection ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Cell Receptor ◽  
Radiation Chimeras ◽  
Gene Usage ◽  
Selection Of

We report here a mAb, 14-2, reactive with TCRs that include V beta 14. The frequency of V beta 14+ T cells varies with CD4 and CD8 subset and is controlled by the H-2 genes. Thus CD8+ T cells from H-2b mice include approximately 2.3% V beta 14+ T cells while CD8+ T cells from mice expressing K kappa include greater than 8% V beta 14+ T cells. In all strains examined, 7-8% of CD4+ T cells express V beta 14. The frequent usage of V beta 14 in CD8+ T cells of K kappa-expressing mice is a result of preferential positive selection of V beta 14+ CD8+ T cells as demonstrated by analysis of radiation chimeras. These studies demonstrate that H-2-dependent positive selection occurs in unmanipulated mice. Furthermore, the results imply that positive selection, and possibly H-2 restriction, can be strongly influenced by a V beta domain, with some independence from the beta-junctional sequence and alpha chain.

scholarly journals Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells

1999 ◽  
Vol 96 (20) ◽  
pp. 11470-11475 ◽  
Author(s):  
J. Zerrahn ◽  
A. Volkmann ◽  
M. C. Coles ◽  
W. Held ◽  
F. A. Lemonnier ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Positive Selection ◽  
T Cell Receptor ◽  
Hematopoietic Cells ◽  
Cell Receptor ◽  
Class I ◽  
Class I Mhc ◽  
Mhc Molecules ◽  
Selection Of
Sign in / Sign up

Export Citation Format

Share Document