scholarly journals Positive selection of self-antigen-specific CD8+T cells by hematopoietic cells

2013 ◽  
Vol 43 (8) ◽  
pp. 2033-2042
Author(s):  
Hisakata Yamada ◽  
Kensuke Shibata ◽  
Koji Sakuraba ◽  
Kenjiro Fujimura ◽  
Yasunobu Yoshikai
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Hematopoietic Cells ◽  
Self Antigen ◽  
Selection Of

scholarly journals Positive selection of MHC class Ib–restricted CD8+ T cells on hematopoietic cells

10.1038/ni814 ◽  
2002 ◽  
Vol 3 (8) ◽  
pp. 772-779 ◽  
Author(s):  
Kevin B. Urdahl ◽  
Joseph C. Sun ◽  
Michael J. Bevan
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Hematopoietic Cells ◽  
Mhc Class Ib ◽  
Class Ib ◽  
Selection Of

Positive Selection of Vβ2+ CD8+ T cells

1992 ◽  
Vol 4 (10) ◽  
pp. 1195-1198 ◽  
Author(s):  
Kyuhei Tomonari
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Selection Of

Positive selection of Tcrb-V4+CD8+ T cells by H-2d molecules

1990 ◽  
Vol 32 (4) ◽  
Author(s):  
Kyuhei Tomonari ◽  
Sue Fairchild
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Selection Of

Repertoire-Determining Role of Peptide in the Positive Selection of CD8+ T cells

1993 ◽  
Vol 135 (1) ◽  
pp. 157-182 ◽  
Author(s):  
Philip G. Ashton-Rickardt ◽  
Luc Van Kaer ◽  
Ton N. M. Schumacher ◽  
Hidde L. Ploegh ◽  
Susumu Tonegawa
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Selection Of

scholarly journals Positive Selection of Extrathymically Developed T Cells by Self-antigens

1998 ◽  
Vol 188 (4) ◽  
pp. 779-784 ◽  
Author(s):  
Hisakata Yamada ◽  
Toshiharu Ninomiya ◽  
Asako Hashimoto ◽  
Koji Tamada ◽  
Hiroaki Takimoto ◽  
...  
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Bone Marrow Cells ◽  
Killer Cell ◽  
Cell Receptor ◽  
Interferon Γ ◽  
Peripheral T Cells ◽  
Self Antigen ◽  
Selection Of ◽  
Self Antigens

Most T cells develop through the thymus, where they undergo positive and negative selection. Some peripheral T cells are known to develop in the absence of thymus, but there is insufficient information about their selection. To analyze the selection of extrathymically developed T cells, we reconstituted thymectomized male or female recipient mice with bone marrow cells of mice transgenic for male H-Y antigen–specific T cell receptor (TCR). It was revealed that the T cells bearing self-antigen–specific TCR were not deleted in thymectomized male recipients. More importantly, the absence of H-Y antigen–specific T cells in thymectomized female recipients suggests positive selection of extrathymically developed T cells by the self-antigen. The extrathymically developed T cells in male mice expressed interleukin (IL)-2 receptor β chain (IL-2Rβ) and intermediate levels of CD3 (CD3int) but were natural killer cell (NK)1.1−. They rapidly produced interferon γ but not IL-4 after TCR cross-linking. Furthermore, a similar pattern of cytokine production was observed in CD3intIL-2Rβ+NK1.1− cells in normal mice which have been shown to develop extrathymically. These results suggest that extrathymically developed CD3intIL-2Rβ+NK1.1− cells in normal mice are also positively selected by self-antigens.

scholarly journals Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.

1989 ◽  
Vol 170 (1) ◽  
pp. 135-143 ◽  
Author(s):  
N S Liao ◽  
J Maltzman ◽  
D H Raulet
Keyword(s):  
T Cells ◽  
T Cell ◽  
Positive Selection ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Cell Receptor ◽  
Radiation Chimeras ◽  
Gene Usage ◽  
Selection Of

We report here a mAb, 14-2, reactive with TCRs that include V beta 14. The frequency of V beta 14+ T cells varies with CD4 and CD8 subset and is controlled by the H-2 genes. Thus CD8+ T cells from H-2b mice include approximately 2.3% V beta 14+ T cells while CD8+ T cells from mice expressing K kappa include greater than 8% V beta 14+ T cells. In all strains examined, 7-8% of CD4+ T cells express V beta 14. The frequent usage of V beta 14 in CD8+ T cells of K kappa-expressing mice is a result of preferential positive selection of V beta 14+ CD8+ T cells as demonstrated by analysis of radiation chimeras. These studies demonstrate that H-2-dependent positive selection occurs in unmanipulated mice. Furthermore, the results imply that positive selection, and possibly H-2 restriction, can be strongly influenced by a V beta domain, with some independence from the beta-junctional sequence and alpha chain.

scholarly journals Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells

1999 ◽  
Vol 96 (20) ◽  
pp. 11470-11475 ◽  
Author(s):  
J. Zerrahn ◽  
A. Volkmann ◽  
M. C. Coles ◽  
W. Held ◽  
F. A. Lemonnier ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Positive Selection ◽  
T Cell Receptor ◽  
Hematopoietic Cells ◽  
Cell Receptor ◽  
Class I ◽  
Class I Mhc ◽  
Mhc Molecules ◽  
Selection Of

scholarly journals Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

Cell ◽  
1993 ◽  
Vol 73 (5) ◽  
pp. 1041-1049 ◽  
Author(s):  
Philip G. Ashton-Rickardt ◽  
Luc Van Kaer ◽  
Ton N.M. Schumacher ◽  
Hidde L. Ploegh ◽  
Susumu Tonegawa
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd8 T Cells ◽  
Selection Of
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