Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces

2007 ◽  
Vol 8 (10) ◽  
pp. 1076-1085 ◽  
Author(s):  
Eilon Woolf ◽  
Irina Grigorova ◽  
Adi Sagiv ◽  
Valentin Grabovsky ◽  
Sara W Feigelson ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Lymphocyte ◽  
Shear Forces ◽  
Lymphocyte Motility

scholarly journals Regulatory T lymphocyte infiltration in metastatic breast cancer—an independent prognostic factor that changes with tumor progression

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Jenny Stenström ◽  
Ingrid Hedenfalk ◽  
Catharina Hagerling
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
T Lymphocytes ◽  
T Lymphocyte ◽  
Metastatic Breast ◽  
Distant Metastases ◽  
Independent Prognostic Factor ◽  
Primary Tumors

Abstract Background Patients diagnosed with metastatic breast cancer have poor outcome with a median survival of approximately 2 years. While novel therapeutic options are urgently needed, the great majority of breast cancer research has focused on the primary tumor and less is known about metastatic breast cancer and the prognostic impact of the metastatic tumor microenvironment. Here we investigate the immune landscape in unique clinical material. We explore how the immune landscape changes with metastatic progression and elucidate the prognostic role of immune cells infiltrating primary tumors and corresponding lymph node and more importantly distant metastases. Methods Immunohistochemical staining was performed on human breast cancer tissue microarrays from primary tumors (n = 231), lymph node metastases (n = 129), and distant metastases (n = 43). Infiltration levels of T lymphocytes (CD3+), regulatory T lymphocytes (Tregs, FOXP3+), macrophages (CD68+), and neutrophils (NE+) were assessed in primary tumors. T lymphocytes and Tregs were further investigated in lymph node and distant metastases. Results T lymphocyte and Treg infiltration were the most clinically important immune cell populations in primary tumors. Infiltration of T lymphocytes and Tregs in primary tumors correlated with proliferation (P = 0.007, P = 0.000) and estrogen receptor negativity (P = 0.046, P = 0.026). While both T lymphocyte and Treg infiltration had a negative correlation to luminal A subtype (P = 0.031, P = 0.000), only Treg infiltration correlated to luminal B (P = 0.034) and triple-negative subtype (P = 0.019). In primary tumors, infiltration of T lymphocytes was an independent prognostic factor for recurrence-free survival (HR = 1.77, CI = 1.01–3.13, P = 0.048), while Treg infiltration was an independent prognostic factor for breast cancer-specific survival (HR = 1.72, CI = 1.14–2.59, P = 0.01). Moreover, breast cancer patients with Treg infiltration in their distant metastases had poor post-recurrence survival (P = 0.039). Treg infiltration levels changed with metastatic tumor progression in 50% of the patients, but there was no significant trend toward neither lower nor higher infiltration. Conclusion Treg infiltration could have clinical applicability as a prognostic biomarker, deciphering metastatic breast cancer patients with worse prognosis, and accordingly, could be a suitable immunotherapeutic target for patients with metastatic breast cancer. Importantly, half of the patients had changes in Treg infiltration during the course of metastatic progression emphasizing the need to characterize the metastatic immune landscape.

Blood and Lymph Node T-Lymphocyte Subsets in Non-Hodgkin Lymphomas

2009 ◽  
Vol 30 (1) ◽  
pp. 68-78 ◽  
Author(s):  
C. LINDEMALM ◽  
H. MELLSTEDT ◽  
P. BIBERFELD ◽  
M. BJÖRKHOLM ◽  
B. CHRISTENSSON ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
T Lymphocyte Subsets

scholarly journals CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input

2011 ◽  
Vol 108 (21) ◽  
pp. 8749-8754 ◽  
Author(s):  
Y. Kumamoto ◽  
L. M. Mattei ◽  
S. Sellers ◽  
G. W. Payne ◽  
A. Iwasaki
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
T Lymphocyte ◽  
Cd4 T Cells ◽  
Cytotoxic T Lymphocyte

Metabolic regulation of T lymphocyte motility and migration

2020 ◽  
pp. 100888
Author(s):  
Juho Vuononvirta ◽  
Federica M. Marelli-Berg ◽  
Thanushiyan Poobalasingam
Keyword(s):  
T Lymphocyte ◽  
Metabolic Regulation ◽  
And Migration ◽  
Lymphocyte Motility

scholarly journals Class IA Phosphoinositide 3-Kinase Modulates Basal Lymphocyte Motility in the Lymph Node

2007 ◽  
Vol 179 (4) ◽  
pp. 2261-2269 ◽  
Author(s):  
Melanie P. Matheu ◽  
Jonathan A. Deane ◽  
Ian Parker ◽  
David A. Fruman ◽  
Michael D. Cahalan
Keyword(s):  
Lymph Node ◽  
Phosphoinositide 3 Kinase ◽  
Lymphocyte Motility
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