The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells

2007 ◽  
Vol 39 (3) ◽  
pp. 386-390 ◽  
Author(s):  
Liqin Cao ◽  
Hiroshi Shitara ◽  
Takuro Horii ◽  
Yasumitsu Nagao ◽  
Hiroshi Imai ◽  
...  
Keyword(s):  
Germ Cells ◽  
Female Mouse

Fate of germ cells in the B6.YDOM XY sex-reversed female mouse

1989 ◽  
Vol 27 ◽  
pp. 161
Author(s):  
T. Taketo-Hosotani ◽  
Y. Nishioka
Keyword(s):  
Germ Cells ◽  
Female Mouse

scholarly journals Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos

RNA ◽  
2009 ◽  
Vol 15 (8) ◽  
pp. 1507-1514 ◽  
Author(s):  
S. Takada ◽  
E. Berezikov ◽  
Y. L. Choi ◽  
Y. Yamashita ◽  
H. Mano
Keyword(s):  
Germ Cells ◽  
Female Mouse ◽  
Potential Role ◽  
Primordial Germ Cells ◽  
Mouse Embryos ◽  
Dnmt3b Expression

scholarly journals Mutation induced in germ cells of the foetal female mouse

1960 ◽  
Vol 1 (1) ◽  
pp. 59-61 ◽  
Author(s):  
T. C. Carter
Keyword(s):  
Great Britain ◽  
Effective Dose ◽  
Germ Cells ◽  
Female Mouse ◽  
High Intensity ◽  
Human Population ◽  
Medical Radiology

In Great Britain by far the greater part of the genetically effective dose of man-made radiation to the human population is due to high-intensity irradiation of the gonads in medical radiology; about a third of it is received by post-natal males, a third by post-natal females, and a third by foetuses, mainly in the later stages of gestation (Osborn & Smith, 1956).

Female mouse germ cells form synchronously dividing cysts

Development ◽  
1998 ◽  
Vol 125 (17) ◽  
pp. 3323-3328 ◽  
Author(s):  
M.E. Pepling ◽  
A.C. Spradling
Keyword(s):  
Confocal Microscopy ◽  
Germ Cells ◽  
Female Mouse ◽  
Progenitor Cell ◽  
Molecular Level ◽  
Cyst Formation ◽  
Intercellular Bridges ◽  
Cell Clusters ◽  
Key Characteristics ◽  
Germline Cyst

Oocytes from many invertebrates initiate development within distinctive cysts of interconnected cells, which are formed through synchronous divisions of a progenitor cell. Recently, processes underlying cyst formation have been extensively characterized at the molecular level in Drosophila. Defects in this process cause sterility in female flies. Early female mouse germ cells are organized as cell clusters as well, but it is uncertain whether these groups are similar to the cysts of invertebrates. We find that mouse germ cells are connected by intercellular bridges in the ovaries of 11.5 to 17.5 days postcoitum embryos; microtubules and organelles have been observed within these bridges. Confocal microscopy shows that cells within mouse clusters divide synchronously and frequently correspond in number to powers of two. Thus, female mouse germ cell clusters exhibit key characteristics of invertebrate germline cysts indicating that the process of germline cyst formation is conserved in the mouse.

scholarly journals XO mice

1962 ◽  
Vol 3 (3) ◽  
pp. 487-490 ◽  
Author(s):  
Bruce M. Cattanach
Keyword(s):  
Germ Cells ◽  
Female Mouse ◽  
Early Stage ◽  
The Body ◽  
The Other ◽  
Normal Female ◽  
Present Communication ◽  
Mouse Development ◽  
X Chromosomes ◽  
Linked Gene

The inactive-X hypothesis (Lyon, 1961) states that in the normal female mouse only one of the two X chromosomes is genetically active in each cell of the body other than the germ-cells, and that the choice of which X is to be inactivated occurs at an early stage of embryogenesis, and is at random in each cell. The descendants of these cells then abide by the decision so that females are mosaics for two lines of cells and may show a mosaic phenotype if they are heterozygous for a sex-linked gene. One requisite for the validity of this hypothesis is that only one X is necessary for the development of a normal female mouse, and evidence substantiating this supposition is the apparent normality of XO mice (Welshons & Russell, 1959; Cattanach, 1961a, b). On the other hand it has been suggested that XO mice are not fully viable (Russell, Russell & Gower, 1959), but no data on the comparative viability and growth of XO female mice have yet been reported. In the present communication data of this nature, collected in the process of setting up an XO stock, are presented and support the hypothesis that only one X chromosome is necessary for normal female mouse development.

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