Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus

2006 ◽  
Vol 38 (6) ◽  
pp. 688-693 ◽  
Author(s):  
Susanne M Clee ◽  
Brian S Yandell ◽  
Kathryn M Schueler ◽  
Mary E Rabaglia ◽  
Oliver C Richards ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Trait Locus

scholarly journals Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

PLoS Genetics ◽  
2011 ◽  
Vol 7 (10) ◽  
pp. e1002323 ◽  
Author(s):  
Sushant Bhatnagar ◽  
Angie T. Oler ◽  
Mary E. Rabaglia ◽  
Donald S. Stapleton ◽  
Kathryn L. Schueler ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Quantitative Trait Locus ◽  
Insulin Secretion ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Negative Regulator ◽  
Trait Locus

scholarly journals A Quantitative Trait Locus Influencing Type 2 Diabetes Susceptibility Maps to a Region on 5q in an Extended French Family

Diabetes ◽  
2002 ◽  
Vol 51 (12) ◽  
pp. 3568-3572 ◽  
Author(s):  
L. J. Martin ◽  
A. G. Comuzzie ◽  
S. Dupont ◽  
N. Vionnet ◽  
C. Dina ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Diabetes Susceptibility ◽  
Susceptibility Maps ◽  
French Family ◽  
Trait Locus

Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1

2010 ◽  
Vol 9 (8) ◽  
pp. 856-867 ◽  
Author(s):  
A. Fortin ◽  
E. Diez ◽  
J. Ritchie ◽  
S. G. Sotocinal ◽  
M.-P. Dube ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Pain Sensitivity ◽  
Trait Locus

Quantitative trait locus mapping and genetic improvement to strengthen drought tolerance in sorghum.

2021 ◽  
pp. 433-443
Author(s):  
Tariq Shehzad ◽  
Kazutoshi Okuno
Keyword(s):  
Quantitative Trait Locus ◽  
Drought Tolerance ◽  
Quantitative Trait ◽  
Genetic Improvement ◽  
Positional Cloning ◽  
Crop Improvement ◽  
New Paradigm ◽  
High Throughput Phenotyping ◽  
Trait Locus ◽  
Locus Mapping

Abstract This chapter overviews the approaches to and application of quantitative trait locus (QTL) mapping and positional cloning of genes controlling important traits related to drought tolerance in sorghum (Sorghum bicolor), which ultimately yields crop improvement and genetic modification. The use of high-throughput phenotyping will help better understand the mechanism involved in response to drought stress by plants. The new paradigm of scientific research should focus on the integration of physiology, genetics, genomics, soil characteristics and breeding to deal with the challenges of food security in the coming years.

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma

2003 ◽  
Vol 34 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Youming Zhang ◽  
Nicholas I Leaves ◽  
Gavin G Anderson ◽  
Chris P Ponting ◽  
John Broxholme ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Immunoglobulin E ◽  
Chromosome 13Q14 ◽  
Trait Locus

scholarly journals A Leishmania major Response Locus Identified by Interval-specific Congenic Mapping of a T Helper Type 2 Cell Bias-controlling Quantitative Trait Locus

2004 ◽  
Vol 200 (12) ◽  
pp. 1605-1612 ◽  
Author(s):  
Aurelie Baguet ◽  
Jennifer Epler ◽  
Kwun W. Wen ◽  
Mark Bix
Keyword(s):  
Quantitative Trait Locus ◽  
T Cell ◽  
Quantitative Trait ◽  
Leishmania Major ◽  
T Helper ◽  
Th2 Cell ◽  
Major Response ◽  
Trait Locus ◽  
Naive T Cell

The propensity of naive CD4 T cells to become T helper (Th) type 2 cells correlates with susceptibility to infection by the protozoal parasite Leishmania major. Using genetic linkage analysis, we earlier identified Dice1 as a Th2 cell bias-controlling quantitative trait locus on chromosome 16. Using interval-specific congenic mapping, we now resolve Dice1 into two independent genetic loci, Dice1.1 and Dice1.2, which control Il4 expression from naive Th cells and thereby indirectly control Th2 cell bias. Interestingly, only one of the two congenic intervals containing Dice1.1 and Dice1.2, respectively, also contained an L. major response locus, indicating that L. major responsiveness can be insensitive to determinants that influence Th2 cell bias by controlling naive T cell Il4 expression. These results lay the groundwork for identifying the Dice1.1 and Dice1.2 genes controlling naive T cell Il4 expression and L. major responses, and for testing whether these control other Th2 cell–dependent processes such as worm expulsion, allergic asthma, and dermatitis.

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