Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma

2003 ◽  
Vol 34 (2) ◽  
pp. 181-186 ◽  
Author(s):  
Youming Zhang ◽  
Nicholas I Leaves ◽  
Gavin G Anderson ◽  
Chris P Ponting ◽  
John Broxholme ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Immunoglobulin E ◽  
Chromosome 13Q14 ◽  
Trait Locus

scholarly journals Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

PLoS Genetics ◽  
2011 ◽  
Vol 7 (10) ◽  
pp. e1002323 ◽  
Author(s):  
Sushant Bhatnagar ◽  
Angie T. Oler ◽  
Mary E. Rabaglia ◽  
Donald S. Stapleton ◽  
Kathryn L. Schueler ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Quantitative Trait Locus ◽  
Insulin Secretion ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Negative Regulator ◽  
Trait Locus

Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1

2010 ◽  
Vol 9 (8) ◽  
pp. 856-867 ◽  
Author(s):  
A. Fortin ◽  
E. Diez ◽  
J. Ritchie ◽  
S. G. Sotocinal ◽  
M.-P. Dube ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Pain Sensitivity ◽  
Trait Locus

Quantitative trait locus mapping and genetic improvement to strengthen drought tolerance in sorghum.

2021 ◽  
pp. 433-443
Author(s):  
Tariq Shehzad ◽  
Kazutoshi Okuno
Keyword(s):  
Quantitative Trait Locus ◽  
Drought Tolerance ◽  
Quantitative Trait ◽  
Genetic Improvement ◽  
Positional Cloning ◽  
Crop Improvement ◽  
New Paradigm ◽  
High Throughput Phenotyping ◽  
Trait Locus ◽  
Locus Mapping

Abstract This chapter overviews the approaches to and application of quantitative trait locus (QTL) mapping and positional cloning of genes controlling important traits related to drought tolerance in sorghum (Sorghum bicolor), which ultimately yields crop improvement and genetic modification. The use of high-throughput phenotyping will help better understand the mechanism involved in response to drought stress by plants. The new paradigm of scientific research should focus on the integration of physiology, genetics, genomics, soil characteristics and breeding to deal with the challenges of food security in the coming years.

scholarly journals A chromosome 16 quantitative trait locus regulates allogeneic bone marrow engraftment in nonmyeloablated mice

Blood ◽  
2009 ◽  
Vol 114 (1) ◽  
pp. 202-210 ◽  
Author(s):  
Thai M. Cao ◽  
Alun Thomas ◽  
Yuanyuan Wang ◽  
Schickwann Tsai ◽  
Kathryn Logronio ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Resistance Mechanisms ◽  
Allogeneic Bone ◽  
Chromosome 16 ◽  
Intermediate Phenotypes ◽  
Trait Locus ◽  
Bone Marrow Engraftment

Abstract Identifying genes that regulate bone marrow (BM) engraftment may reveal molecular targets for overcoming engraftment barriers. To achieve this aim, we applied a forward genetic approach in a mouse model of nonmyeloablative BM transplantation. We evaluated engraftment of allogeneic and syngeneic BM in BALB.K and B10.BR recipients. This allowed us to partition engraftment resistance into its intermediate phenotypes, which are firstly the immune-mediated resistance and secondly the nonimmune rejection of donor BM cells. We observed that BALB.K and B10.BR mice differed with regard to each of these resistance mechanisms, thereby providing evidence that both are under genetic control. We then generated a segregating backcross (n = 200) between the BALB.K and B10.BR strains to analyze for genetic linkage to the allogeneic BM engraftment phenotype using a 127-marker genome scan. This analysis identified a novel quantitative trait locus (QTL) on chromosome 16, termed Bmgr5 (logarithm of odds 6.4, at 11.1 cM). The QTL encodes susceptibility alleles, from the BALB.K strain, that are permissive for allogeneic BM engraftment. Further identification of Bmgr5 genes by positional cloning may reveal new and effective approaches for overcoming BM engraftment obstacles.

scholarly journals Mice That Are Congenic for the char2 Locus Are Susceptible to Malaria

2002 ◽  
Vol 70 (8) ◽  
pp. 4750-4753 ◽  
Author(s):  
Rachel A. Burt ◽  
Vikki M. Marshall ◽  
Jamie Wagglen ◽  
Fleur R. Rodda ◽  
Danielle Senyschen ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Significant Role ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Major Advance ◽  
Plasmodium Chabaudi ◽  
Malarial Infection ◽  
Trait Locus

ABSTRACT A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus

2006 ◽  
Vol 38 (6) ◽  
pp. 688-693 ◽  
Author(s):  
Susanne M Clee ◽  
Brian S Yandell ◽  
Kathryn M Schueler ◽  
Mary E Rabaglia ◽  
Oliver C Richards ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Positional Cloning ◽  
Trait Locus
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