Molecular genetic basis of the human Rhesus blood group system

1993 ◽  
Vol 5 (1) ◽  
pp. 62-65 ◽  
Author(s):  
Isabelle Mouro ◽  
Yves Colin ◽  
Baya Chérif-Zahar ◽  
Jean-Pierre Cartron ◽  
Caroline Le Van Kim
Keyword(s):  
Blood Group ◽  
Genetic Basis ◽  
Molecular Genetic ◽  
Blood Group System ◽  
Group System ◽  
Molecular Genetic Basis ◽  
Rhesus Blood Group ◽  
Rhesus Blood Group System

scholarly journals Identification and partial characterization of the human erythrocyte membrane component(s) that express the antigens of the LW blood-group system

1986 ◽  
Vol 234 (3) ◽  
pp. 649-652 ◽  
Author(s):  
G Mallinson ◽  
P G Martin ◽  
D J Anstee ◽  
M J A Tanner ◽  
A H Merry ◽  
...  
Keyword(s):  
Blood Group ◽  
Polyacrylamide Gel Electrophoresis ◽  
Broad Band ◽  
Osmotic Fragility ◽  
Human Erythrocytes ◽  
Blood Group System ◽  
Group System ◽  
Normal Human ◽  
Rhesus Blood Group ◽  
Rhesus Blood Group System

Rhnull human erythrocytes lack the antigens of the Rhesus blood-group system, have an abnormal shape, have an increased osmotic fragility, and are associated with mild chronic haemolytic anaemia. Rhnull erythrocytes also lack all antigens of the LW blood-group system, but the functional significance of this deficiency is unknown. We have identified, by immunoblotting with two mouse monoclonal antibodies (BS46 and BS56), the LW-active component(s) in normal human erythrocytes as a broad band of Mr 37 000-47 000 on SDS/polyacrylamide-gel electrophoresis. Treatment of intact human erythrocytes with endoglycosidase F preparation destroyed the epitopes recognized by antibodies BS46 and BS56, suggesting that one or more N-glycosidically linked oligosaccharides are required for the formation of the LW antigens. Estimation of the number of LW antigen sites per erythrocyte by using radioiodinated purified antibody BS46 gave average values of 4400 molecules/cell for Rh(D)-positive adult erythrocytes and 2835 molecules/cell for Rh(D)-negative adult erythrocytes. Like the Rh(D) polypeptide, the LW polypeptide(s) is (are) associated with the cytoskeleton of normal erythrocytes. These results suggest the possibility that the absence of the LW polypeptide may also contribute to the functional and/or morphological abnormalities of Rhnull erythrocytes.

scholarly journals Genetic Analysis of ABO and Rh Blood Groups in Backward Caste Population of Uttar Pradesh, India

2011 ◽  
Vol 3 (3) ◽  
pp. 07-14 ◽  
Author(s):  
Vandana RAI ◽  
Pradeep KUMAR
Keyword(s):  
Blood Group ◽  
Uttar Pradesh ◽  
Blood Groups ◽  
Blood Type ◽  
Allele Frequency Distribution ◽  
Blood Group System ◽  
Blood Group Antigens ◽  
Group System ◽  
Rhesus Blood Group ◽  
Rhesus Blood Group System

A series of glycoproteins and glycolipids on red blood cell surface constitute blood group antigens. These are AB, A, B and O in ABO blood group system and Rh in rhesus blood group system. A total of 1065 unrelated Backward Caste (OBC) individuals from Uttar Pradesh were studied for the phenotype and allele frequency distribution of ABO and Rh (D) blood groups. Total 1065 samples analyzed, phenotype B blood type has the highest frequency 36.81% (n=392), followed by O (32.68%; n=348), A (23.66%; n=252) and AB (6.85%; n=73). The overall phenotypic frequencies of ABO blood groups were B>O>A>AB. The allelic frequencies of O, A, and B alleles were 0.5819, 0.1674 and 0.2506 respectively. Out of total 1065 samples, 1018 (95.59%) samples were Rh-positive and 47 (4.41%) were Rh-negative. Phenotypic frequency of Rh-negative in Koari, Yadav, Kurmi and Maurya samples were 0.99%, 4%, 1.4% and 7.6% respectively.

Seed Agglutinin with Specificity within the Rhesus Blood Group System

Nature ◽  
1968 ◽  
Vol 219 (5154) ◽  
pp. 653-653 ◽  
Author(s):  
G. W. G. BIRD ◽  
JUNE WINGHAM
Keyword(s):  
Blood Group ◽  
Blood Group System ◽  
Group System ◽  
Rhesus Blood Group ◽  
Rhesus Blood Group System

Distribution of Rhesus Blood Group System in the French Basques: A Reappraisal Using the Allele-Specific Primers PCR Method

2004 ◽  
Vol 58 (2) ◽  
pp. 69-72 ◽  
Author(s):  
Mhammed Touinssi ◽  
Jacques Chiaroni ◽  
Anna Degioanni ◽  
Philippe De Micco ◽  
Olivier Dutour ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Group System ◽  
Specific Primers ◽  
Group System ◽  
Allele Specific ◽  
Pcr Method ◽  
Rhesus Blood Group ◽  
Rhesus Blood Group System
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