Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

1997 ◽  
Vol 16 (2) ◽  
pp. 154-160 ◽  
Author(s):  
Deepak Srivastava ◽  
Tiffani Thomas ◽  
Qing Lin ◽  
Margaret L. Kirby ◽  
Doris Brown ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Neural Crest ◽  
Bhlh Transcription Factor ◽  
Neural Crest Development

scholarly journals Lineage-specific requirements of β-catenin in neural crest development

2002 ◽  
Vol 159 (5) ◽  
pp. 867-880 ◽  
Author(s):  
Lisette Hari ◽  
Véronique Brault ◽  
Maurice Kléber ◽  
Hye-Youn Lee ◽  
Fabian Ille ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Neural Crest Stem Cells ◽  
Downstream Signaling ◽  
Neural Crest Development ◽  
Sensory Neurogenesis

β-Catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream signaling component of Wnt that controls multiple developmental processes such as cell proliferation, apoptosis, and fate decisions. To study the role of β-catenin in neural crest development, we used the Cre/loxP system to ablate β-catenin specifically in neural crest stem cells. Although several neural crest–derived structures develop normally, mutant animals lack melanocytes and dorsal root ganglia (DRG). In vivo and in vitro analyses revealed that mutant neural crest cells emigrate but fail to generate an early wave of sensory neurogenesis that is normally marked by the transcription factor neurogenin (ngn) 2. This indicates a role of β-catenin in premigratory or early migratory neural crest and points to heterogeneity of neural crest cells at the earliest stages of crest development. In addition, migratory neural crest cells lateral to the neural tube do not aggregate to form DRG and are unable to produce a later wave of sensory neurogenesis usually marked by the transcription factor ngn1. We propose that the requirement of β-catenin for the specification of melanocytes and sensory neuronal lineages reflects roles of β-catenin both in Wnt signaling and in mediating cell–cell interactions.

scholarly journals Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development

2003 ◽  
Vol 229 (1) ◽  
pp. 74-86 ◽  
Author(s):  
Yoshio Wakamatsu ◽  
Yukinori Endo ◽  
Noriko Osumi ◽  
James A. Weston
Keyword(s):  
Transcription Factor ◽  
Neural Crest ◽  
Multiple Roles ◽  
Hmg Box ◽  
Neural Crest Development

scholarly journals Expression and function of transcription factor cMyb during cranial neural crest development

2014 ◽  
Vol 132 ◽  
pp. 38-43 ◽  
Author(s):  
Paola Betancur ◽  
Marcos Simões-Costa ◽  
Tatjana Sauka-Spengler ◽  
Marianne E. Bronner
Keyword(s):  
Transcription Factor ◽  
Neural Crest ◽  
Cranial Neural Crest ◽  
Neural Crest Development ◽  
And Function
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