scholarly journals Expression and function of transcription factor cMyb during cranial neural crest development

2014 ◽  
Vol 132 ◽  
pp. 38-43 ◽  
Author(s):  
Paola Betancur ◽  
Marcos Simões-Costa ◽  
Tatjana Sauka-Spengler ◽  
Marianne E. Bronner
Keyword(s):  
Transcription Factor ◽  
Neural Crest ◽  
Cranial Neural Crest ◽  
Neural Crest Development ◽  
And Function

Zika virus induces abnormal cranial osteogenesis by negatively affecting cranial neural crest development

2019 ◽  
Vol 69 ◽  
pp. 176-189 ◽  
Author(s):  
Yuqi Yan ◽  
Xiao-tan Zhang ◽  
Guang Wang ◽  
Xin Cheng ◽  
Yu Yan ◽  
...  
Keyword(s):  
Neural Crest ◽  
Zika Virus ◽  
Cranial Neural Crest ◽  
Neural Crest Development

scholarly journals Lineage-specific requirements of β-catenin in neural crest development

2002 ◽  
Vol 159 (5) ◽  
pp. 867-880 ◽  
Author(s):  
Lisette Hari ◽  
Véronique Brault ◽  
Maurice Kléber ◽  
Hye-Youn Lee ◽  
Fabian Ille ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Neural Crest Stem Cells ◽  
Downstream Signaling ◽  
Neural Crest Development ◽  
Sensory Neurogenesis

β-Catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream signaling component of Wnt that controls multiple developmental processes such as cell proliferation, apoptosis, and fate decisions. To study the role of β-catenin in neural crest development, we used the Cre/loxP system to ablate β-catenin specifically in neural crest stem cells. Although several neural crest–derived structures develop normally, mutant animals lack melanocytes and dorsal root ganglia (DRG). In vivo and in vitro analyses revealed that mutant neural crest cells emigrate but fail to generate an early wave of sensory neurogenesis that is normally marked by the transcription factor neurogenin (ngn) 2. This indicates a role of β-catenin in premigratory or early migratory neural crest and points to heterogeneity of neural crest cells at the earliest stages of crest development. In addition, migratory neural crest cells lateral to the neural tube do not aggregate to form DRG and are unable to produce a later wave of sensory neurogenesis usually marked by the transcription factor ngn1. We propose that the requirement of β-catenin for the specification of melanocytes and sensory neuronal lineages reflects roles of β-catenin both in Wnt signaling and in mediating cell–cell interactions.

scholarly journals The role of Sip1 in cranial neural crest development

2011 ◽  
Vol 356 (1) ◽  
pp. 238-239 ◽  
Author(s):  
Crystal Rogers ◽  
Marianne Bronner-Fraser
Keyword(s):  
Neural Crest ◽  
Cranial Neural Crest ◽  
Neural Crest Development

Cell death in cranial neural crest development

1992 ◽  
Vol 185 (6) ◽  
Author(s):  
Pete Jeffs ◽  
Karen Jaques ◽  
Mark Osmond
Keyword(s):  
Cell Death ◽  
Neural Crest ◽  
Cranial Neural Crest ◽  
Neural Crest Development

scholarly journals Single-Cell Multiomic Approaches Reveal Diverse Labeling of the Nervous System by Common Cre-Drivers

2021 ◽  
Vol 15 ◽  
Author(s):  
Rachel A. Keuls ◽  
Ronald J. Parchem
Keyword(s):  
Nervous System ◽  
Neural Crest ◽  
Single Cell ◽  
System Development ◽  
Cell Types ◽  
Nervous System Development ◽  
Cellular Heterogeneity ◽  
Cranial Neural Crest ◽  
Developmental Potential ◽  
Neural Crest Development

Neural crest development involves a series of dynamic, carefully coordinated events that result in human disease when not properly orchestrated. Cranial neural crest cells acquire unique multipotent developmental potential upon specification to generate a broad variety of cell types. Studies of early mammalian neural crest and nervous system development often use the Cre-loxP system to lineage trace and mark cells for further investigation. Here, we carefully profile the activity of two common neural crest Cre-drivers at the end of neurulation in mice. RNA sequencing of labeled cells at E9.5 reveals that Wnt1-Cre2 marks cells with neuronal characteristics consistent with neuroepithelial expression, whereas Sox10-Cre predominantly labels the migratory neural crest. We used single-cell mRNA and single-cell ATAC sequencing to profile the expression of Wnt1 and Sox10 and identify transcription factors that may regulate the expression of Wnt1-Cre2 in the neuroepithelium and Sox10-Cre in the migratory neural crest. Our data identify cellular heterogeneity during cranial neural crest development and identify specific populations labeled by two Cre-drivers in the developing nervous system.

scholarly journals Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development

2003 ◽  
Vol 229 (1) ◽  
pp. 74-86 ◽  
Author(s):  
Yoshio Wakamatsu ◽  
Yukinori Endo ◽  
Noriko Osumi ◽  
James A. Weston
Keyword(s):  
Transcription Factor ◽  
Neural Crest ◽  
Multiple Roles ◽  
Hmg Box ◽  
Neural Crest Development
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