Distribution of olfactory receptor genes in the human genome

1998 ◽  
Vol 18 (3) ◽  
pp. 243-250 ◽  
Author(s):  
Sylvie Rouquier ◽  
Sylvie Taviaux ◽  
Barbara J. Trask ◽  
Véronique Brand-Arpon ◽  
Ger van den Engh ◽  
...  
Genetics ◽  
1997 ◽  
Vol 145 (1) ◽  
pp. 185-195 ◽  
Author(s):  
Laurie Issel-Tarver ◽  
Jasper Rine

We performed a comparative study of four subfamilies of olfactory receptor genes first identified in the dog to assess changes in the gene family during mammalian evolution, and to begin linking the dog genetic map to that of humans. The human subfamilies were localized to chromosomes 7, 11, and 19. The two subfamilies that were tightly linked in the dog genome were also tightly linked in the human genome. The four subfamilies were compared in human (primate), horse (perissodactyl), and a variety of artiodactyls and carnivores. Some changes in gene number were detected, but overall subfamily size appeared to have been established before the divergence of these mammals 60–100 million years ago.


2014 ◽  
Author(s):  
Takushi Kishida ◽  
J. G. M. Thewissen ◽  
Sharon Usip ◽  
John C George ◽  
Robert S Suydam

Although modern baleen whales still possess a functional olfactory systems that includes olfactory bulbs, cranial nerve I and olfactory receptor genes, their olfactory capabilities have been reduced profoundly. This is probably in response to their fully aquatic lifestyle. The glomeruli that occur in the olfactory bulb can be divided into two non-overlapping domains, a dorsal domain and a ventral domain. Recent molecular studies revealed that all modern whales have lost olfactory receptor genes and marker genes that are specific to the dorsal domain, and that a modern baleen whale possess only 60 olfactory receptor genes. Here we show that olfactory bulb of bowhead whales (Balaena mysticetus, Mysticeti) lacks glomeruli on the dorsal side, consistent with the molecular data. In addition, we estimate that there are more than 4,000 glomeruli in the bowhead whale olfactory bulb. Olfactory sensory neurons that express the same olfactory receptor in mice generally project to two specific glomeruli in an olfactory bulb, meaning that ratio of the number of olfactory receptors : the number of glomeruli is approximately 1:2. However, we show here that this ratio is not applicable to whales, indicating the limitation of mice as model organisms for understanding the initial coding of odor information among mammals.


Gene ◽  
2002 ◽  
Vol 282 (1-2) ◽  
pp. 113-120 ◽  
Author(s):  
Rumi Kondo ◽  
Satoko Kaneko ◽  
Hui Sun ◽  
Mitsuru Sakaizumi ◽  
Sadao I. Chigusa

1996 ◽  
Vol 47 (1-2) ◽  
pp. 65
Author(s):  
Gallinaro Hélène ◽  
Amadou claire ◽  
Avoustin Philippe ◽  
Ribouchon Marie ◽  
Bouissou Catherine ◽  
...  

2012 ◽  
Vol 105 (3) ◽  
pp. 772-776 ◽  
Author(s):  
Anne C. Choquette ◽  
Luigi Bouchard ◽  
Vicky Drapeau ◽  
Simone Lemieux ◽  
Angelo Tremblay ◽  
...  

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