Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

2010 ◽  
Vol 42 (8) ◽  
pp. 703-706 ◽  
Author(s):  
Nobuhisa Mizuki ◽  
Akira Meguro ◽  
Masao Ota ◽  
Shigeaki Ohno ◽  
Tomoko Shiota ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Disease Susceptibility ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Susceptibility Loci ◽  
Behcet's Disease ◽  
Genome Wide

scholarly journals Genetics of Behçet's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Tamer İrfan Kaya
Keyword(s):  
Behçet’S Disease ◽  
Disease Susceptibility ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Association Studies ◽  
Silk Road ◽  
Inflammatory Disorder ◽  
Genome Wide Association Studies ◽  
Genetic Associations ◽  
Behcet's Disease

Behçet's disease (BD) is a systemic inflammatory disorder characterized mainly by recurrent oral and genital ulcers and eye involvement. Although the pathogenesis remains poorly understood, a variety of studies have demonstrated that genetic predisposition is a major factor in disease susceptibility. Peculiar geographical distribution of BD along the ancient Silk Road has been regarded as evidence supporting genetic influence. The observed aggregation of BD in families of patients with BD is also supportive for a genetic component in its etiology. HLA-B51 (B510101 subtype) is the most strongly associated genetic marker for BD in countries on the Silk Road. In recent years, several genome-wide association studies and genetic polymorphism studies have also found new genetic associations with BD, which may have a supplementary role in disease susceptibility and/or severity. The author reviewed the HLA and non-HLA genetic association studies.

scholarly journals Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

2013 ◽  
Vol 45 (2) ◽  
pp. 202-207 ◽  
Author(s):  
Yohei Kirino ◽  
George Bertsias ◽  
Yoshiaki Ishigatsubo ◽  
Nobuhisa Mizuki ◽  
Ilknur Tugal-Tutkun ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Association Analysis ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Behcet's Disease ◽  
Genome Wide Association Analysis ◽  
Genome Wide

scholarly journals Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

2010 ◽  
Vol 42 (8) ◽  
pp. 698-702 ◽  
Author(s):  
Elaine F Remmers ◽  
Fulya Cosan ◽  
Yohei Kirino ◽  
Michael J Ombrello ◽  
Neslihan Abaci ◽  
...  
Keyword(s):  
Association Study ◽  
Mhc Class I ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Genome Wide Association Study ◽  
Behçet's Disease ◽  
Genome Wide Association ◽  
Class I ◽  
Behcet's Disease ◽  
Genome Wide

scholarly journals Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study

2009 ◽  
Vol 11 (3) ◽  
pp. R66 ◽  
Author(s):  
Yiping Fei ◽  
Ryan Webb ◽  
Beth L Cobb ◽  
Haner Direskeneli ◽  
Güher Saruhan-Direskeneli ◽  
...  
Keyword(s):  
Association Study ◽  
Genetic Susceptibility ◽  
Behcet’S Disease ◽  
Genome Wide Association Study ◽  
Behçet's Disease ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Behcet's Disease ◽  
Genome Wide ◽  
A Genome
Sign in / Sign up

Export Citation Format

Share Document