scholarly journals Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

2013 ◽  
Vol 45 (2) ◽  
pp. 202-207 ◽  
Author(s):  
Yohei Kirino ◽  
George Bertsias ◽  
Yoshiaki Ishigatsubo ◽  
Nobuhisa Mizuki ◽  
Ilknur Tugal-Tutkun ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Association Analysis ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Behcet's Disease ◽  
Genome Wide Association Analysis ◽  
Genome Wide

scholarly journals Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

2010 ◽  
Vol 42 (8) ◽  
pp. 698-702 ◽  
Author(s):  
Elaine F Remmers ◽  
Fulya Cosan ◽  
Yohei Kirino ◽  
Michael J Ombrello ◽  
Neslihan Abaci ◽  
...  
Keyword(s):  
Association Study ◽  
Mhc Class I ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Genome Wide Association Study ◽  
Behçet's Disease ◽  
Genome Wide Association ◽  
Class I ◽  
Behcet's Disease ◽  
Genome Wide

scholarly journals Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study

2009 ◽  
Vol 11 (3) ◽  
pp. R66 ◽  
Author(s):  
Yiping Fei ◽  
Ryan Webb ◽  
Beth L Cobb ◽  
Haner Direskeneli ◽  
Güher Saruhan-Direskeneli ◽  
...  
Keyword(s):  
Association Study ◽  
Genetic Susceptibility ◽  
Behcet’S Disease ◽  
Genome Wide Association Study ◽  
Behçet's Disease ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Behcet's Disease ◽  
Genome Wide ◽  
A Genome

scholarly journals Association of LACC1, CEBPB-PTPN1, RIPK2 and ADO-EGR2 with ocular Behcet’s disease in a Chinese Han population

2018 ◽  
Vol 102 (9) ◽  
pp. 1308-1314 ◽  
Author(s):  
Pengcheng Wu ◽  
Liping Du ◽  
Shengping Hou ◽  
Guannan Su ◽  
Lu Yang ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Meta Analysis ◽  
Allelic Association ◽  
Nucleotide Polymorphisms ◽  
Genetic Loci ◽  
Chinese Han ◽  
Behcet's Disease ◽  
Genome Wide

BackgroundAn Immunochip study recently identified the association of a number of new genetic loci with Behcet’s disease (BD).ObjectiveTo confirm the association between new genetic loci reported in an Immunochip study and BD in a Han Chinese population.MethodsA two-stage association study was carried out in 1238 patients with BD and 1458 healthy controls. Twenty-two candidate single nucleotide polymorphisms (SNPs) were selected for genotyping by iPLEXGold genotyping or TaqMan SNP assays and a meta-analysis was performed for significantly associated markers.ResultsThe results showed that four SNPs (LACC1/rs9316059, CEBPB-PTPN1/rs913678, ADO-EGR2/rs224127 and RIPK2/rs10094579) were associated with BD in an allelic association test (rs9316059 T allele: pc=4.95×10−8, OR=0.687; rs913678 C allele: pc=3.01×10−4, OR=1.297; rs224127 A allele: pc=3.77×10−4, OR=1.274; rs10094579 A allele: pc=6.93×10−4, OR=1.302). For four SNPs tested by meta-analysis, the association with BD was strengthened and all exceeded genome-wide significance (rs9316059: p=2.96×10−16; rs913678: p=2.09×10−16; rs224127: p=5.28×10−13; rs10094579: p=9.21×10−11).ConclusionsOur findings confirmed the association of four loci (LACC1, CEBPB-PTPN1, ADO-EGR2 and RIPK2) in Chinese Han patients with BD.

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