Can a low-sodium, high-potassium salt substitute reduce blood pressure in rural Chinese people?

2008 ◽  
Vol 5 (4) ◽  
pp. 186-187 ◽  
Author(s):  
Feng J He ◽  
Graham A MacGregor
Keyword(s):  
Blood Pressure ◽  
Potassium Salt ◽  
Reduce Blood Pressure ◽  
Chinese People ◽  
High Potassium ◽  
Low Sodium ◽  
Salt Substitute

The Effect of Potassium and Bicarbonate Ions on the Rise in Blood Pressure Caused by Sodium Chloride

1982 ◽  
Vol 63 (s8) ◽  
pp. 407s-409s ◽  
Author(s):  
T. O. Morgan
Keyword(s):  
Blood Pressure ◽  
Sodium Chloride ◽  
Sodium Bicarbonate ◽  
Potassium Chloride ◽  
Mild Hypertension ◽  
Sodium Intake ◽  
Reduce Blood Pressure ◽  
High Potassium ◽  
Bicarbonate Ions ◽  
Low Sodium

1. A group of eight patients with mild hypertension, sensitive to sodium intake, were studied. 2. Sodium chloride (70 mmol daily) caused their blood pressure to rise by 19/14 mmHg. 3. Sodium bicarbonate (70 mmol daily) caused their blood pressure to rise by 12/5 mmHg. 4. Sodium chloride given together with potassium chloride (70 mmol of each daily) caused their blood pressure to rise by 9.6 mmHg. 5. These results suggest that sodium bicarbonate causes a smaller rise in blood pressure than sodium chloride does and that potassium chloride reduces the blood pressure raising effect of sodium chloride. 6. A low sodium, high potassium and an alkaline diet may therefore be a more effective dietary method to reduce blood pressure than a diet low in sodium alone.

scholarly journals Kidney Is Essential for Blood Pressure Modulation by Dietary Potassium

2020 ◽  
Vol 22 (10) ◽  
Author(s):  
Xiao-Tong Su ◽  
Chao-Ling Yang ◽  
David H. Ellison
Keyword(s):  
Blood Pressure ◽  
Potassium Concentration ◽  
Blood Pressure Reduction ◽  
Chloride Concentration ◽  
Plasma Potassium ◽  
Reduce Blood Pressure ◽  
Fluid Volume ◽  
Extracellular Potassium ◽  
High Potassium ◽  
Extracellular Potassium Concentration

Abstract Eating more potassium may reduce blood pressure and the occurrence of other cardiovascular diseases by actions on various systems, including the vasculature, the sympathetic nervous system, systemic metabolism, and body fluid volume. Among these, the kidney plays a major role in the potassium-rich diet–mediated blood pressure reduction. Purpose of Review To provide an overview of recent discoveries about the mechanisms by which a potassium-rich diet leads to natriuresis. Recent Findings Although the distal convoluted tubule (DCT) is a short part of the nephron that reabsorbs salt, via the sodium-chloride cotransporter (NCC), it is highly sensitive to changes in plasma potassium concentration. Activation or inhibition of NCC raises or lowers blood pressure. Recent work suggests that extracellular potassium concentration is sensed by the DCT via intracellular chloride concentration which regulates WNK kinases in the DCT. Summary High-potassium diet targets NCC in the DCT, resulting in natriuresis and fluid volume reduction, which are protective from hypertension and other cardiovascular problems.

Effects of a low-sodium high-potassium salt in hypertensive patients treated with metoprolol

1988 ◽  
Vol 6 (10) ◽  
pp. 787???790 ◽  
Author(s):  
Giuseppe Suppa ◽  
Giorgio Pollavini ◽  
Daniele Alberti ◽  
Stefano Savonitto
Keyword(s):  
Potassium Salt ◽  
High Potassium ◽  
Hypertensive Patients ◽  
Low Sodium

scholarly journals Core Strategies to Increase the Uptake and Use of Potassium-Enriched Low-Sodium Salt

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3203
Author(s):  
Adefunke Ajenikoko ◽  
Nicole Ide ◽  
Roopa Shivashankar ◽  
Zeng Ge ◽  
Matti Marklund ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sodium Salt ◽  
Program Implementation ◽  
Sodium Intake ◽  
Scale Up ◽  
Population Level ◽  
Reduce Blood Pressure ◽  
Dietary Sodium ◽  
Potassium Intake ◽  
Low Sodium

Excess sodium consumption and insufficient potassium intake contribute to high blood pressure and thus increase the risk of heart disease and stroke. In low-sodium salt, a portion of the sodium in salt (the amount varies, typically ranging from 10 to 50%) is replaced with minerals such as potassium chloride. Low-sodium salt may be an effective, scalable, and sustainable approach to reduce sodium and therefore reduce blood pressure and cardiovascular disease at the population level. Low-sodium salt programs have not been widely scaled up, although they have the potential to both reduce dietary sodium intake and increase dietary potassium intake. This article proposes a framework for a successful scale-up of low-sodium salt use in the home through four core strategies: availability, awareness and promotion, affordability, and advocacy. This framework identifies challenges and potential solutions within the core strategies to begin to understand the pathway to successful program implementation and evaluation of low-sodium salt use.

Abstract 072: Newly Developed Personal Device can Detect Changes and Variations of Urinary Na/K Ratio with Standardized Low- and High-salt Meals in Healthy Volunteers

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Junichi Yatabe ◽  
Midori S Yatabe ◽  
Kozue Takano ◽  
Ami Watanabe ◽  
Satsuki Kurosawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Healthy Volunteers ◽  
Sodium Level ◽  
High Salt ◽  
High Potassium ◽  
Blood Pressure Elevation ◽  
Spot Urine ◽  
Low Sodium ◽  
Blood Pressure Difference ◽  
Low Salt

Background: A low-sodium (Na), high-potassium (K) diet is recommended to suppress blood pressure elevation, but determining the absolute amounts of Na and K in a diet is difficult. A novel portable device was developed to allow easy measurement of urinary Na/K ratio on the spot. In this study, our aims were 1): to observe the changes of urinary Na/K ratio in subjects on low- and high-Na diet and 2): to determine if there are differences in urinary Na/K ratio between subjects with and without salt sensitivity. Methods: Healthy volunteers (14 subjects) ingested standardized low- (3 g NaCl /day) and high-Na (20 g NaCl/day) meals for 7 days each. Urinary Na/K ratio was measured at each voiding using a prototype device (Omron Healthcare). Collection of blood and 24-hour urine was conducted at the end of each diet period (unrestricted (NS), low-salt (LS), and high-salt (HS)). Those with mean blood pressure difference (LS vs. HS) ≥ 5% were determined as salt-sensitive (SS) and others salt-resistant (SR). Results: Urinary Na/K ratio reached a plateau approximately 3 days after each change in the Na level of the diet. Urinary Na/K ratio of spot urine correlated well with Na/K ratio of 24-hour urine. Average urinary Na/K ratio was 3.9 ± 1.9 on the last day of NS, 0.8 ± 0.3 on LS, and 6.9 ± 2.1 on HS. The variation of urinary Na/K ratio was small during the LS diet period. The change in urinary Na/K ratio of SS group tended to be slower than that of SR. This device may also be useful in diabetic and proteinuric patients as Na/K ratio was affected minimally by experimental glucose and protein addition. Conclusion: Using an easy-to-use device, measurements of urinary Na/K ratio keenly reflected the sodium level of the diet.

scholarly journals Launching a salt substitute to reduce blood pressure at the population level: a cluster randomized stepped wedge trial in Peru

Trials ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 93 ◽  
Author(s):  
Antonio Bernabe-Ortiz ◽  
Francisco Diez-Canseco ◽  
Robert H Gilman ◽  
María K Cárdenas ◽  
Katherine A Sacksteder ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Population Level ◽  
Reduce Blood Pressure ◽  
Stepped Wedge ◽  
Salt Substitute ◽  
Cluster Randomized ◽  
Stepped Wedge Trial
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