scholarly journals Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Teng Zuo ◽  
Jianfeng Sun ◽  
Guiqin Wang ◽  
Liwei Jiang ◽  
Yanan Zuo ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Neutralizing Antibodies ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Highly Pathogenic ◽  
Protective Antibody ◽  
H5n1 Infection ◽  
Antibody Recognition ◽  
Pathogenic Avian Influenza ◽  
Globular Head

Abstract Understanding the mechanism of protective antibody recognition against highly pathogenic avian influenza A virus H5N1 in humans is critical for the development of effective therapies and vaccines. Here we report the crystal structure of three H5-specific human monoclonal antibodies bound to the globular head of hemagglutinin (HA) with distinct epitope specificities, neutralization potencies and breadth. A structural and functional analysis of these epitopes combined with those reported elsewhere identifies four major vulnerable sites on the globular head of H5N1 HA. Chimeric and vulnerable site-specific mutant pseudoviruses are generated to delineate broad neutralization specificities of convalescent sera from two individuals who recovered from the infection with H5N1 virus. Our results show that the four vulnerable sites on the globular head rather than the stem region are the major neutralizing targets, suggesting that during natural H5N1 infection neutralizing antibodies against the globular head work in concert to provide protective antibody-mediated immunity.

scholarly journals Prevention of Highly Pathogenic Avian Influenza A/H5N1 Infection by Passive Immunotherapy Using Antiserum

2018 ◽  
Vol 08 (11) ◽  
pp. 874-884
Author(s):  
Kazuhide Adachi ◽  
Ganita Kurniasih Suryaman ◽  
Retno Damajanti Soejoedono ◽  
Ekowati Handharyani ◽  
Yasuhiro Tsukamoto
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Highly Pathogenic ◽  
Passive Immunotherapy ◽  
H5n1 Infection ◽  
Pathogenic Avian Influenza

scholarly journals Seven human cases of H5N1 infection confirmed in Azerbaijan, and one case in Egypt

2006 ◽  
Vol 11 (12) ◽  
Author(s):  
Collective Editorial team
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Highly Pathogenic ◽  
H5n1 Infection ◽  
Pathogenic Avian Influenza

Seven human cases of infection with highly pathogenic avian influenza A(H5N1) in Azerbaijan have now been confirmed

scholarly journals Suppression of Highly Pathogenic Avian Influenza A/H5N1 Infection Using Migratory Antibody Passed from Mother to Chick

2018 ◽  
Vol 08 (04) ◽  
pp. 89-97 ◽  
Author(s):  
Kazuhide Adachi ◽  
Ganita Kurniasih Suryaman ◽  
Retno Damajanti Soejoedono ◽  
Ekowati Handharyani ◽  
Yasuhiro Tsukamoto
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Highly Pathogenic ◽  
H5n1 Infection ◽  
Pathogenic Avian Influenza

scholarly journals First detection of highly pathogenic avian influenza virus in Norway

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Knut Madslien ◽  
Torfinn Moldal ◽  
Britt Gjerset ◽  
Sveinn Gudmundsson ◽  
Arne Follestad ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Wild Birds ◽  
Zoonotic Potential ◽  
Active Monitoring ◽  
Main Hypothesis ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
Poultry Farms

Abstract Background Several outbreaks of highly pathogenic avian influenza (HPAI) caused by influenza A virus of subtype H5N8 have been reported in wild birds and poultry in Europe during autumn 2020. Norway is one of the few countries in Europe that had not previously detected HPAI virus, despite widespread active monitoring of both domestic and wild birds since 2005. Results We report detection of HPAI virus subtype H5N8 in a wild pink-footed goose (Anser brachyrhynchus), and several other geese, ducks and a gull, from south-western Norway in November and December 2020. Despite previous reports of low pathogenic avian influenza (LPAI), this constitutes the first detections of HPAI in Norway. Conclusions The mode of introduction is unclear, but a northward migration of infected geese or gulls from Denmark or the Netherlands during the autumn of 2020 is currently our main hypothesis for the introduction of HPAI to Norway. The presence of HPAI in wild birds constitutes a new, and ongoing, threat to the Norwegian poultry industry, and compliance with the improved biosecurity measures on poultry farms should therefore be ensured. [MK1]Finally, although HPAI of subtype H5N8 has been reported to have very low zoonotic potential, this is a reminder that HPAI with greater zoonotic potential in wild birds may pose a threat in the future. [MK1]Updated with a sentence emphasizing the risk HPAI pose to poultry farms, both in the Abstract and in the Conclusion-section in main text, as suggested by Reviewer 1 (#7).

scholarly journals Unusually High Mortality in Waterfowl Caused by Highly Pathogenic Avian Influenza A(H5N1) in Bangladesh

2015 ◽  
Vol 64 (1) ◽  
pp. 144-156 ◽  
Author(s):  
N. Haider ◽  
K. Sturm-Ramirez ◽  
S. U. Khan ◽  
M. Z. Rahman ◽  
S. Sarkar ◽  
...  
Keyword(s):  
Avian Influenza ◽  
High Mortality ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza

scholarly journals Pathologic Changes in Wild Birds Infected with Highly Pathogenic Avian Influenza A(H5N8) Viruses, South Korea, 2014

2015 ◽  
Vol 21 (5) ◽  
pp. 775-780 ◽  
Author(s):  
Hye-Ryoung Kim ◽  
Yong-Kuk Kwon ◽  
Il Jang ◽  
Youn-Jeong Lee ◽  
Hyun-Mi Kang ◽  
...  
Keyword(s):  
Avian Influenza ◽  
South Korea ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Wild Birds ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza
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