scholarly journals Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Andres Garelli ◽  
Fabiana Heredia ◽  
Andreia P. Casimiro ◽  
Andre Macedo ◽  
Catarina Nunes ◽  
...  
Keyword(s):  
Developmental Timing ◽  
Couple Growth ◽  
Relaxin Receptor

scholarly journals Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing

2015 ◽  
Author(s):  
Andres Garelli ◽  
Fabiana Heredia ◽  
Andreia P. Casimiro ◽  
Andre Macedo ◽  
Catarina Nunes ◽  
...  
Keyword(s):  
Imaginal Disc ◽  
The Body ◽  
Peripheral Tissue ◽  
Developmental Timing ◽  
Couple Growth ◽  
Cns Neurons ◽  
Stress Signal ◽  
Relaxin Receptor ◽  
Body Sense

How different organs in the body sense growth perturbations in distant tissues to coordinate their size during development is poorly understood. Here, we mutated an invertebrate orphan relaxin receptor, the Drosophila Lgr3, and found body asymmetries similar to those found in insulin/relaxin-like peptide 8 (dilp8) mutants, which fail to coordinate growth with developmental timing. Indeed, mutation or RNAi against Lgr3 suppresses the delay in pupariation induced by imaginal disc growth perturbation or ectopic Dilp8 expression. By fluorescently-tagging the endogenous Lgr3 protein and performing CNS-specific RNAi, we find that Lgr3 is expressed and required in a novel subset of CNS neurons to transmit the peripheral tissue stress signal, Dilp8, to the neuroendocrine centers controlling developmental timing. Our work sheds new light on the function and evolution of relaxin receptors and reveals a novel neuroendocrine circuit responsive to growth aberrations.

scholarly journals Characterizing relaxin receptor expression and exploring relaxin’s effect on tissue remodeling/fibrosis in the human bladder

BMC Urology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Edward C. Diaz ◽  
Mason Briggs ◽  
Yan Wen ◽  
Guobing Zhuang ◽  
Shannon L. Wallace ◽  
...  
Keyword(s):  
Tissue Remodeling ◽  
Receptor Expression ◽  
Human Bladder ◽  
Relaxin Receptor

scholarly journals Epigenetic regulation of developmental timing in floral stem cells

Epigenetics ◽  
2009 ◽  
Vol 4 (8) ◽  
pp. 564-567 ◽  
Author(s):  
Toshiro Ito ◽  
Bo Sun
Keyword(s):  
Stem Cells ◽  
Epigenetic Regulation ◽  
Developmental Timing

Altered developmental timing in early life stages of Antarctic krill (Euphausia superba) exposed to p,p′-DDE

2011 ◽  
Vol 409 (24) ◽  
pp. 5268-5276 ◽  
Author(s):  
Anita H. Poulsen ◽  
So Kawaguchi ◽  
Matti T. Leppänen ◽  
Jussi V.K. Kukkonen ◽  
Susan M. Bengtson Nash
Keyword(s):  
Early Life ◽  
Antarctic Krill ◽  
Euphausia Superba ◽  
Developmental Timing ◽  
Life Stages ◽  
Early Life Stages ◽  
Antarctic Krill Euphausia Superba

scholarly journals Regulatory Mutations of mir-48, a C. elegans let-7 Family MicroRNA, Cause Developmental Timing Defects

2005 ◽  
Vol 9 (3) ◽  
pp. 415-422 ◽  
Author(s):  
Ming Li ◽  
Matthew W. Jones-Rhoades ◽  
Nelson C. Lau ◽  
David P. Bartel ◽  
Ann E. Rougvie
Keyword(s):  
Developmental Timing ◽  
C Elegans ◽  
Regulatory Mutations ◽  
Timing Defects
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