scholarly journals PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Tatsuro Nakamura ◽  
Shingo Maeda ◽  
Kazuhide Horiguchi ◽  
Toko Maehara ◽  
Kosuke Aritake ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Hyperplasia ◽  
Food Antigen ◽  
Mast Cell Hyperplasia

Pharmacologic inhibition of Notch signaling suppresses food antigen–induced mucosal mast cell hyperplasia

2017 ◽  
Vol 139 (3) ◽  
pp. 987-996.e10 ◽  
Author(s):  
Asuka Honjo ◽  
Nobuhiro Nakano ◽  
Susumu Yamazaki ◽  
Mutsuko Hara ◽  
Koichiro Uchida ◽  
...  
Keyword(s):  
Mast Cell ◽  
Notch Signaling ◽  
Mucosal Mast Cell ◽  
Cell Hyperplasia ◽  
Food Antigen ◽  
Mast Cell Hyperplasia ◽  
Pharmacologic Inhibition

scholarly journals Effects of Multiple Dexamethasone Treatments on Aggravation of Allergic Conjunctivitis Associated with Mast Cell Hyperplasia

2008 ◽  
Vol 31 (3) ◽  
pp. 464-468 ◽  
Author(s):  
Takuya Nagata ◽  
Takeshi Nabe ◽  
Masanori Fujii ◽  
Nobuaki Mizutani ◽  
Shigekatsu Kohno
Keyword(s):  
Mast Cell ◽  
Allergic Conjunctivitis ◽  
Cell Hyperplasia ◽  
Mast Cell Hyperplasia

Lung mast cell density and distribution in chronically hypoxic animals

1977 ◽  
Vol 42 (2) ◽  
pp. 174-178 ◽  
Author(s):  
A. Tucker ◽  
I. F. McMurtry ◽  
A. F. Alexander ◽  
J. T. Reeves ◽  
R. F. Grover
Keyword(s):  
Cell Proliferation ◽  
Pulmonary Hypertension ◽  
Mast Cell ◽  
Mast Cells ◽  
Cell Density ◽  
Mammalian Species ◽  
Cell Hyperplasia ◽  
Mast Cell Density ◽  
Lung Mast Cell ◽  
Mast Cell Hyperplasia

Changes in the density and distribution of pulmonary mast cells were determined in six mammalian species exposed to hypobaric hypoxia (PB = 435 Torr) for 19–48 days. Control animals were studied at 1,600 m (PB = 635 Torr). Total lung mast cell hyperplasia was observed only in calves exposed to high altitude. Pigs, rats, and sheep exhibited small, but insignificant, increases in mast cell density. Perivascular mast cell proliferation adjacent to vessels of 30–500 mum in diameter was seen in both calves and pigs. Bronchial, alveolar septal, and systemic tissue (tongue) mast cell hyperplasia was not observed in any of the species. Three indices of pulmonary hypertension (right ventricular hypertrophy, medial thickness of pulmonary arteries, and pulmonary arterial pressure) correlated with perivascular mast cell density. The findings indicate that perivascular mast cell proliferation may relate more to the morphological pulmonary vascular changes and to pulmonary hypertension than to hypoxia, leading to the speculation that mast cells increase in number in response to the hypertension, rather than to mediate and maintain the hypertension.

Mast Cell Hyperplasia in Experimental Hypersensitivity Pneumonitis

1991 ◽  
Vol 96 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Patrick J. Haley ◽  
Mark Schuyler ◽  
Katherine Gott ◽  
Thomas B. Casale
Keyword(s):  
Mast Cell ◽  
Hypersensitivity Pneumonitis ◽  
Cell Hyperplasia ◽  
Mast Cell Hyperplasia

Association of the Q576R polymorphism in the interleukin-4 receptor α chain with indolent mastocytosis limited to the skin

Blood ◽  
2001 ◽  
Vol 98 (3) ◽  
pp. 880-882 ◽  
Author(s):  
Trisha Daley ◽  
Dean D. Metcalfe ◽  
Cem Akin
Keyword(s):  
Mast Cell ◽  
Systemic Mastocytosis ◽  
Interleukin 4 ◽  
Gain Of Function ◽  
Cell Hyperplasia ◽  
Α Subunit ◽  
Disease Markers ◽  
Α Chain ◽  
Interleukin 4 Receptor ◽  
Mast Cell Hyperplasia

Abstract Gain-of-function mutations in c-kit, which appear to contribute to mast cell hyperplasia, have been detected in both limited and aggressive forms of mastocytosis, suggesting that other mutations or polymorphisms may contribute to the clinical phenotype. Because addition of interleukin-4 (IL-4) to mast cell cultures is reported to induce apoptosis, the hypothesis was considered that individuals carrying the gain-of-function polymorphism Q576R in the cytoplasmic domain of the α-subunit of the IL-4 receptor (IL-4R) might be relatively resistant to the gain-of-function mutation in c-kit. To assess this possibility, 36 patients with either cutaneous or systemic mastocytosis were studied for association with the Q576R polymorphism. The Q576R polymorphism was found more frequently in those with disease limited to skin and who exhibited lower levels of surrogate disease markers. These data suggest that the Q576R IL-4R α- chain polymorphism may mitigate disease expression and confer a better prognosis in patients with mastocytosis.

Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice

2008 ◽  
Vol 60 (10) ◽  
pp. 599-607 ◽  
Author(s):  
Ming-Cai Zhang ◽  
Hiroshi Furukawa ◽  
Kazuhiro Tokunaka ◽  
Kan Saiga ◽  
Fumiko Date ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Hyperplasia ◽  
Mast Cell Hyperplasia
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