Mast cell stabilizing compound FPL 55618 reduces right ventricular hypertrophy and lung mast cell hyperplasia in chronically hypoxic rats

1981 ◽  
Vol 37 (1) ◽  
pp. 75-76 ◽  
Author(s):  
J. M. Kay ◽  
K. L. Suyama ◽  
P. M. Keane
Keyword(s):  
Mast Cell ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Cell Hyperplasia ◽  
Lung Mast Cell ◽  
Mast Cell Hyperplasia

Effects of Nitric Oxide on Monocrotaline Induced Right Ventricular Hypertrophy and Lung Mast Cell Hyperplasia in Rats

1998 ◽  
Vol 4 (S2) ◽  
pp. 1072-1073
Author(s):  
Kuen-Shan Hung ◽  
William H. Duncan
Keyword(s):  
Nitric Oxide ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Sprague Dawley ◽  
Cell Hyperplasia ◽  
Arterial Walls ◽  
Sprague Dawley Rats ◽  
Pulmonary Arterial ◽  
Mast Cell Hyperplasia

Monocrotaline (M) induces pulmonary hypertension (PH) characterized by increased pulmonary arterial pressure, thickened pulmonary arterial walls, and right ventricular hypertrophy (RVH). In addition, numerous mast cells (MC) have been localized in M treated rats and these cells may have a role in causing PH and other lung injury because of their content of serotonin, which is a vasoconstrictor. Nitric oxide (NO) is a vasodilator that has been used in treatments of human patients and experimental animals with PH. The purpose of this study is to determine if NO inhalation can prevent or reverse RVH or MC accumulation induced by M.Adult male Sprague-Dawley rats were divided into 5 groups (C, M3, MN3, M5, MN5). Group C served as controls without treatments. Groups M3 and M5 received one single subcutaneous injection of M (80mg/kg BW) and were sacrificed at 3 weeks (M3) or 5 weeks (M5) after injection.

Lung mast cell density and distribution in chronically hypoxic animals

1977 ◽  
Vol 42 (2) ◽  
pp. 174-178 ◽  
Author(s):  
A. Tucker ◽  
I. F. McMurtry ◽  
A. F. Alexander ◽  
J. T. Reeves ◽  
R. F. Grover
Keyword(s):  
Cell Proliferation ◽  
Pulmonary Hypertension ◽  
Mast Cell ◽  
Mast Cells ◽  
Cell Density ◽  
Mammalian Species ◽  
Cell Hyperplasia ◽  
Mast Cell Density ◽  
Lung Mast Cell ◽  
Mast Cell Hyperplasia

Changes in the density and distribution of pulmonary mast cells were determined in six mammalian species exposed to hypobaric hypoxia (PB = 435 Torr) for 19–48 days. Control animals were studied at 1,600 m (PB = 635 Torr). Total lung mast cell hyperplasia was observed only in calves exposed to high altitude. Pigs, rats, and sheep exhibited small, but insignificant, increases in mast cell density. Perivascular mast cell proliferation adjacent to vessels of 30–500 mum in diameter was seen in both calves and pigs. Bronchial, alveolar septal, and systemic tissue (tongue) mast cell hyperplasia was not observed in any of the species. Three indices of pulmonary hypertension (right ventricular hypertrophy, medial thickness of pulmonary arteries, and pulmonary arterial pressure) correlated with perivascular mast cell density. The findings indicate that perivascular mast cell proliferation may relate more to the morphological pulmonary vascular changes and to pulmonary hypertension than to hypoxia, leading to the speculation that mast cells increase in number in response to the hypertension, rather than to mediate and maintain the hypertension.

Lung vessel leak precedes right ventricular hypertrophy in monocrotaline-treated rats

1983 ◽  
Vol 54 (2) ◽  
pp. 371-374 ◽  
Author(s):  
T. Sugita ◽  
T. M. Hyers ◽  
I. M. Dauber ◽  
W. W. Wagner ◽  
I. F. McMurtry ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Dry Weight ◽  
Lavage Fluid ◽  
Right Ventricular Hypertrophy ◽  
Lung Water ◽  
Cell Hyperplasia ◽  
Albumin Content ◽  
The Right

Monocrotaline induces microvascular leak and pulmonary hypertension in rats. We have hypothesized that the leak is related in some way to the pulmonary hypertension and precedes it. In rats given 40 mg monocrotaline/kg body wt subcutaneously, lung wet weight-to-dry weight ratios and lung albumin content began to increase within the first 3 days and became maximal at 1 wk. Alveolar lavage fluid showed little or no increase in protein. Right ventricular hypertrophy increased progressively from 2 through 3 wk. An increase in lung dry weight paralleled the right ventricular hypertrophy. The amount of blood retained in the lung did not account for the increased lung water, albumin, or weight. We considered that microvascular leak without leak into the alveolar space preceded pulmonary hypertension, right ventricular hypertrophy, and increased lung dry weight. In rats not given monocrotaline but exposed for 3 wk to hypobaric hypoxia, lung albumin, lung dry weight, and right ventricular weight increased. Increased lung dry weight probably reflects hyperplasia of lung cells. If so, an association of microvascular leak, lung cell hyperplasia, and right ventricular hypertrophy may occur in both monocrotaline- and hypoxia-induced pulmonary hypertension.

Left and right ventricular hypertrophy at autopsy of hypertensive individuals

2012 ◽  
Vol 58 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Mirella Pessoa Sant’Anna ◽  
Roberto José Vieira de Mello ◽  
Luciano Tavares Montenegro ◽  
Mônica Modesto Araújo
Keyword(s):  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy ◽  
Left And Right

Role of microRNA-21 in right ventricular hypertrophy and fibrosis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
J Neumann ◽  
W Janssen ◽  
B Kojonazarov ◽  
C Döbele ◽  
HA Ghofrani ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Ventricular Hypertrophy ◽  
Right Ventricular Hypertrophy

scholarly journals RNA Expression Profiles and Regulatory Networks in Human Right Ventricular Hypertrophy due to High Pressure Load

iScience ◽  
2021 ◽  
pp. 102232
Author(s):  
Philippe Chouvarine ◽  
Joachim Photiadis ◽  
Robert Cesnjevar ◽  
Jens Scheewe ◽  
Ulrike MM. Bauer ◽  
...  
Keyword(s):  
High Pressure ◽  
Right Ventricular ◽  
Regulatory Networks ◽  
Ventricular Hypertrophy ◽  
Expression Profiles ◽  
Right Ventricular Hypertrophy ◽  
Rna Expression ◽  
Human Right ◽  
Pressure Load
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